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    ISTA Thesis

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    ISTA Thesis

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    ISTA Thesis

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    On the size of chromatic Delaunay mosaics

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    Given a locally finite set A⊆Rd and a coloring χ:A→{0,1,…,s}, we introduce the chromatic Delaunay mosaic of χ, which is a Delaunay mosaic in Rs+d that represents how points of different colors mingle. Our main results are bounds on the size of the chromatic Delaunay mosaic, in which we assume that d and s are constants. For example, if A is finite with n=#A, and the coloring is random, then the chromatic Delaunay mosaic has O(n⌈d/2⌉) cells in expectation. In contrast, for Delone sets and Poisson point processes in Rd, the expected number of cells within a closed ball is only a constant times the number of points in this ball. Furthermore, in R2 all colorings of a dense set of n points have chromatic Delaunay mosaics of size O(n). This encourages the use of chromatic Delaunay mosaics in applications

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    ISTA Thesis

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    ISTA Thesis

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    The Hamilton space of pseudorandom graphs

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    We show that if n is odd and p>=Clog n/n, then with high probability Hamilton cycles in G(n,p) span its cycle space. More generally, we show this holds for a class of graphs satisfying certain natural pseudorandom properties. The proof is based on a novel idea of parity-switchers, which can be thought of as analogues of absorbers in the context of cycle spaces. As another application of our method, we show that Hamilton cycles in a near-Dirac graph G, that is, a graph G with odd n vertices and minimum degree n/2+C for sufficiently large constant C, span its cycle space

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    Mutation rates represent the net result of complex interactions among various cellular processes and can dramatically influence the evolutionary fate of microbial populations. However, many popular techniques used to study mutations are subject to the confounding effects of heredity and the subtleties of adaptation to selection, all of which make it difficult to observe any dynamic responses of mutation rates to fitness challenges. Furthermore, in spite of the ubiquity of quorum sensing systems across the bacterial domain and relevance for many physiological behaviors, the effects of such mechanisms on mutation rate and adaptation remain poorly understood. In the following work, I present the development of a microfluidic droplet-based method to measure single base-pair mutation rates in growing populations of the bacterium Escherichia coli. I use this method to observe a stress-induced increase in mutation rate that is mediated by luxS, a highly conserved bacterial quorum sensing component. I also show that the aforementioned increase in mutation rate, and its associated control by luxS, corresponds to a higher degree of adaptability under competitive environments

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    IST Austria: PubRep (Institute of Science and Technology)
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