Campbell University
CU FIND (Campbell University, Catherine W. Wood School of Nursing)Not a member yet
9287 research outputs found
Sort by
Optimizing the synergistic effect of CuWO4-CuS hybrid composites for photocatalytic inactivation of pathogenic bacteria
No full textWIN55212-2 modulates intracellular calcium via CB1 receptor-dependent and independent mechanisms in neuroblastoma cells
No full text
Discovery of a functionally-selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine
No full textAssessing validity and reproducibility of goniometry: establishing the use of a markerless video motion capture system
No full text
Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma
No full textThe apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms remain poorly understood. Here, we found that in two mouse glaucoma models, microglia transitioned to a neurodegenerative phenotype characterized by upregulation of Apoe and Lgals3 (Galectin-3), which were also upregulated in human glaucomatous retinas. Mice with targeted deletion of Apoe in microglia or carrying the human APOE4 allele were protected from retinal ganglion cell (RGC) loss, despite elevated intraocular pressure (IOP). Similarly to Apoe retinal microglia, APOE4-expressing microglia did not upregulate neurodegeneration-associated genes, including Lgals3, following IOP elevation. Genetic and pharmacologic targeting of Galectin-3 ameliorated RGC degeneration, and Galectin-3 expression was attenuated in human APOE4 glaucoma samples. These results demonstrate that impaired activation of APOE4 microglia is protective in glaucoma and that the APOE-Galectin-3 signaling can be targeted to treat this blinding disease
