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TCT-220 Real-world Utilization of PASCAL Precision System in non-A2P2 Degenerative Mitral Regurgitation
No full textBackground: Mitral valve transcatheter edge-to-edge repair (M-TEER) has historically been considered more challenging in the commissural regions of the mitral valve (A1P1, A3P3) compared to central regions (A2P2). Data on outcomes with contemporary M-TEER by implant location are limited. Methods: Degenerative mitral regurgitation (DMR) patients treated with the PASCAL Precision system between Sep 2022-Oct 2024 using a single PASCAL or PASCAL Ace implant were analyzed by device location (A2P2 vs non-A2P2) from the STS/ACC TVT Registry. Procedural, clinical, and echocardiographic outcomes to 30 days were assessed. All outcomes were site-reported. Results: The study comprised 1207 patients categorized into two groups: patients with a single implant at A2P2 (n=977) and those with a single implant at non-A2P2 position (n=230). Patients in the A2P2 group were younger, majority female, had lower incidence of flail leaflet, and a higher incidence of heart failure hospitalization (HFH) and leaflet calcification. There were no aborted procedures in either group, and successful device implantation was achieved in a high proportion of patients, 98.2% in the A2P2 group vs. 97.0% in the non-A2P2 group (P=0.299). Procedure duration was shorter in the A2P2 group (77.0 min) vs. non-A2P2 group (86.0 min) (P=0.053). The PASCAL Ace implant was used more frequently in the non-A2P2 group (87.4%) compared to A2P2 group (67.0%) (P\u3c0.001). At 30 days, the incidence of adverse events was low and comparable in both the A2P2 and non-A2P2 groups [mortality: 1.9% vs. 2.6%; mitral valve reintervention: 0.3% vs. 0%; HFH: 1.6% vs. 3.0%; single leaflet device attachment (SLDA): 0.1% vs. 0.4%; all P\u3e0.05]. MR reduction at 30 days was similar in the A2P2 vs non-A2P2 groups (P=0.997) with MR≤2+ and MR≤1+ rates of 94.9% vs. 95.8% and 72.0% vs. 74.3%, respectively. Conclusion: In a real-world setting, DMR patients treated with the PASCAL Precision system in both commissural and non-commissural implant locations experienced high survival, significant MR reduction and low incidence of adverse events, including SLDA, HFH and mitral valve reintervention at 30 days. Categories: STRUCTURAL: Valvular Disease and Intervention: Mitra
The Data Rescue Project: Protecting Public Access to Public Data
No full textThe U.S. government is one of the world’s largest publishers of data and research, with offices and agencies like the Census Bureau, Bureau of Labor Statistics, USAID, and the Department of Education playing key but distinct roles in collecting, analyzing, and disseminating information across various fields. During the first Trump administration, groups began a data preservation effort, but the scope of the challenge was much smaller. Since January 2025, the scope of the threat has increased. To address the expanding data preservation efforts, a group of data librarians and archivists in February 2025 organized the Data Rescue Project (DRP), a clearinghouse for data rescue-related efforts focused on at-risk public U.S. governmental data. The DRP has operated on multiple tracks simultaneously. We have run our own data rescues, training volunteers to back up datasets on to ICPSR\u27s crowdsourced Data Lumos repository. We have also launched the Data Rescue Portal, a website that tracks data rescues from multiple groups, increasing the findability and accessibility of rescued datasets. Additionally, we are supporting other projects such as the Save our Signs effort to archive National Parks interpretive signs. In this presentation, I will cover the current activities of the DRP and discuss how attendees can get involved to help protect public access to public data
Unwilling, Unable, Unsafe: A Policy to Meet Unusual Sharing Requests
No full textAs funders require increased sharing, researchers are facing increased requests where they have concerns about sharing the data both in and beyond repositories. In order to anticipate these requests and establish a mechanism for response, the University of Illinois Chicago developed a data policy and framework to address sharing requests where a research is unwilling to share the data, unable to share the data, or they feel that the request makes them or their study subjects unsafe. This lightning talk will provide an overview of the considerations of the policy, the framework of the committee who will implement it, and the outcomes we hope for with providing this resource
Integrating Digital Archives & Scholarship: Raising Awareness of Library Historical Collections
No full textSince 2022, The TMC Library started using Digital Commons Exhibits, adding 15k items to its 18yr institution repository to include more library archival materials. Traffic of archival collections jumped from 4k, 36k to 107k downloads in 2024, bringing greater impact to not only archives, but the entire library community. Other beneficial impacts have been identified since additional archival materials have been integrated within our institutional repository. Other than more people who have been accessing McGovern Historical Center using their services and materials, The Texas Medical Center Library has noticed changes since more download traffic has been noticed on our institutional repository. In general, more foot traffic, in terms of students using our library services, study rooms, as well as our research materials have also increased. To date, The Texas Medical Center has been utilizing Digital Commons since 2005, starting at 2 articles in 2005, and The Texas Medical Center Library reached its 2 million download milestone in January 2024. We are looking forward to reaching our next milestone when we get to 3 million soon
Crosswalk that Talk: Migrating Interview Collections Using Existing Metadata
No full textThis presentation outlines the novel method developed by the Historical Resources Center (HRC) at MD Anderson Cancer Center for migrating its oral history collection between platforms. The HRC’s model for maximizing accessibility involves segmenting each interview into chapters, each with a title, abstract, and subject headings. The system also aims to present both the media files and transcripts of interviews simultaneously. Over the past fifteen years, the collection has undergone multiple processing and publishing models. At one point, the archives relied on four software platforms: a browser-based display system, CONTENTdm and LibGuides for search and browsing, and ArchivesSpace for finding aids. While this setup was complex and required extensive metadata generation, it was stable and effective. Due to unforeseen circumstances, the public browser’s server and ArchivesSpace were retired, and Digital Commons replaced CONTENTdm. This prompted the development of a new publishing model: interviews posted to Digital Commons, and metadata managed in a new ArchivesSpace instance. The archivist repurposed existing metadata sources to build a Microsoft Excel-based crosswalk, enabling batch import of interviews and metadata into the new platforms. The crosswalk spreadsheet linked Dublin Core and EAD schemas, formatted metadata, and exported batch-ready files. Digital Commons supported Excel uploads, while ArchivesSpace used XML via EAD templates. Batch uploading proved faster than manual entry, offering benefits such as consistency, reduced errors, and quicker processing. This adaptable model demonstrates an efficient approach to migrating oral history interviews using existing metadata and standardized crosswalks
Beyond the diagnosis: The socioeconomic burden of SBS patients dependent on parenteral support
No full textRationale: Short bowel syndrome (SBS) is a debilitating condition, often requiring long-term parenteral support (PS), that can significantly impact patients’ health, employment, and daily functioning. This study assessed the socioeconomic burden of SBS. Methods: A noninterventional, cross-sectional, online survey capturing employment status, caregiver dependence, healthcare utilization (hospitalization emergency department [ED] visits), and quality of life (QoL) was conducted in the US and Europe among patients (≥18 years) diagnosed with SBS on parenteral support. QoL was assessed with the Short Form 36 Health Survey, Acute Version 2 (SF-36v2), which measured SBS treatment impact on patient functioning; norm-based scores were compared with the US general population mean of 50.0. Results: 91 patients completed the survey (mean age: 50.4 years; 58.2% female, 69.1% White). Patients were receiving total parenteral nutrition (TPN; 90.1%) and or IV hydration (73.6%) and glucagon-like peptide-2 analog therapy (24.2%). SBS impacted employment: 22.0% of patients were employed and 25.3% were permanently disabled. Among all patients, 57.3% missed ≥1 day of work school daily tasks in the past week and 25.8% missed ≥4 days. High healthcare utilization: 27.5% were hospitalized for SBS-related complications in the past 6 months and 41.8% had ED visits. 76.9% relied on informal caregiving, averaging 17.9 hours week. Poor QoL: patients with SBS had notably lower functioning across all daily work activity-related domains (SF-36v2 score range, 36.8-42.2) compared with the general population mean of 50. SF-36v2 Physical and Social Functioning scores were 41.9 and 38.6, respectively. Conclusion: SBS imposes a severe socioeconomic burden (disability, missed work, caregiver need, hospital ED visits, and diminished QoL), underscoring a critical need for improved treatments and support systems to reduce this burden and enhance patient outcomes. Disclosure of Interest: J. Harrison Other: Volunteer for Girls With Guts, S.-M. Jafri Consultant for: Intercept, Ironwood, AbbVie, Gilead, Takeda, and Ipsen, R. Vemulapalli Other: CME Faculty for Novus Medical Education, G. Mitchell Other: Employee of Ironwood and may hold shares and or stock options in the company., D. Wolin Other: Full-time employee of RTI Health Solutions, an independent nonprofit research organization, which was retained by Ironwood to conduct the research that is the subject of this abstract. Their compensation is unconnected to the studies on which they work., L. Zografos Other: Full-time employee of RTI Health Solutions, an independent nonprofit research organization, which was retained by Ironwood to conduct the research that is the subject of this abstract. Their compensation is unconnected to the studies on which they work., M. Yang Other: Employee of Ironwood and may hold shares and or stock options in the company., L. Jackson Other: Full-time employee of RTI Health Solutions, an independent nonprofit research organization, which was retained by Ironwood to conduct the research that is the subject of this abstract. Their compensation is unconnected to the studies on which they work., J. Wang Other: Full-time employee of RTI Health Solutions, an independent nonprofit research organization, which was retained by Ironwood to conduct the research that is the subject of this abstract. Their compensation is unconnected to the studies on which they work., J. Henderson Other: Employee of Ironwood and may hold shares and or stock options in the company., M. Boules Other: Employee of Ironwood and may hold shares and or stock options in the company., V. Kumpf Consultant for: Ironwood, Baxter Healthcare, and Fresenius Kab
Establishment of standardized definitions and a core set of outcome characteristics following hidradenitis suppurativa surgery developed by an expert Delphi consensus
No full textBACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition often requiring surgical intervention for definitive treatment. Previous studies evaluated postsurgical outcomes, but no standardization exists for collection and nomenclature for HS surgical outcomes.
OBJECTIVE: To characterize and define surgical outcome terminology.
METHODS: A modified Delphi protocol was used to reach consensus on data to collect and terms to describe outcomes following HS surgical procedures. A five-member steering committee created preliminary definitions and surveys, which were distributed via Qualtrics to a group of international HS experts. A nine-point Likert scale was used, and a score of at least 7 was needed for an item to reach agreement.
RESULTS: Twenty-five dermatologists and general and plastic surgeons participated in the Delphi study. Following 2 rounds of surveys and feedback, the consensus terminology to describe outcomes included surgical site and regional persistence and progression. Consensus was also reached on key features to report as part of each outcome.
LIMITATIONS: Limitations include narrow scope and small number of participants from limited geographical areas.
CONCLUSION: Surgery persistence and progression definitions were agreed upon by a group of international HS experts. This consensus is a first step toward standardizing terminology and reporting for HS surgical outcomes
Safety and Tolerability of Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Truncal Acne
No full textBACKGROUND: Truncal acne is underdiagnosed and undertreated, and it can lead to scarring and postinflammatory hyperpigmentation. However, applying topical treatments to larger skin surface areas introduces additional safety/tolerability concerns. Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel is the only fixed-dose, triple-combination topical for acne and has demonstrated favorable efficacy/safety in participants with facial acne.
METHODS: Data were pooled from one phase 2 (NCT04892706) and two phase 3 (NCT04214639, NCT04214652), double-blind, 12-week studies. Participants aged ≥9 years (≥12 years, phase 2) with moderate to severe facial acne were randomized to once daily CAB or vehicle gel. Truncal acne treatment was optional, and efficacy was not the main outcome. Truncal treatment-emergent adverse events (TEAEs) and truncal cutaneous safety/tolerability were evaluated through week 12. Only participants treating both face and trunk were included in this post hoc analysis (CAB, n=118; vehicle, n=101).
RESULTS: Through week 12, TEAE rates on the trunk were higher with CAB vs vehicle (5.9% vs 1.0%). Most TEAEs were mild, none were serious, and only 1 participant (CAB-treated) discontinued due to TEAEs. Mean truncal cutaneous safety/tolerability scores with CAB were \u3c 0.5 (1=mild) at all visits. Severe (grade 3) ratings postbaseline occurred in \u3c 1% of CAB-treated participants for erythema, hyperpigmentation, and burning (n=1 each).
CONCLUSIONS: In this pooled analysis, fixed-dose CAB gel was well tolerated over 12 weeks in participants treating their truncal acne. The lack of safety signals combined with the favorable safety/tolerability profile of CAB shows that it is a safe treatment option for truncal and facial acne
Challenges in the Treatment of Hepatorenal Syndrome-Acute Kidney Injury: A US Chart Review of Treatment Patterns and Survival Outcomes
No full textBACKGROUND: Treatments for hepatorenal syndrome with acute kidney injury (HRS-AKI) that are not FDA-approved have been widely used in the United States (US) with variable outcomes. This study describes the practice patterns, outcomes, and healthcare utilization around vasopressor use before terlipressin approval in 2022.
METHODS: A retrospective chart review study was conducted at 10 US medical centers, assessing adult patients diagnosed with HRS-AKI between 2016 and 2019. The primary outcome was treatment response (change in serum creatinine [SCr] from the day of vasopressor treatment initiation to Day 14/vasopressor discontinuation). Secondary outcomes included overall and transplant-free survival, treatment patterns, and healthcare resource use.
RESULTS: Of the 198 eligible patients, 129 and 69 had mild/moderate (SCr \u3c 5 mg/dL, acute-on-chronic liver failure [ACLF] ≤ 2) and severe disease (SCr ≥ 5 mg/dL, ACLF \u3e 2), respectively. The mean age was 57 years; 52.5% were males, and 71.2% were White. Alcohol-associated cirrhosis (53.5%) was the most common cause of cirrhosis. All 198 patients had a physician-diagnosed HRS-AKI, and only 30.3% met all International Club of Ascites (ICA)-HRS criteria. Most patients (85.4%) initiated treatment with midodrine and octreotide for a median of 7 days. The overall response rate (n = 157) was 20.3%. Median (95% CI) overall and transplant-free survival from vasopressor initiation was 48 (32-81) and 28 (19-36) days. Notably, 33.8% of patients died during hospitalization, and 31.3% required renal replacement therapy.
CONCLUSION: Before 2022, hospitalized HRS-AKI patients experienced suboptimal treatment response with off-label treatments and poor survival. There remains an unmet need for safe and effective non-transplant treatments for hospitalized HRS-AKI patients in the United States
Determining the Impact of Medical Arabic Workshops on Medical Students\u27 Preparedness and Communication Skills With Arabic-Speaking Patients
No full textIntroduction: While Wayne State University School of Medicine (WSUSOM) serves a large Arab-American patient population, medical students have limited opportunities for formal instruction in medical Arabic, which may hinder effective communication with Arabic-speaking patients. To address this gap, a series of medical Arabic workshops was implemented, focusing on medical terminology and patient interaction. This study evaluates the impact of these workshops on students\u27 self-reported preparedness and confidence when interacting with Arabic-speaking patients. Notably, there is a lack of prior US-based studies examining the effectiveness of structured medical Arabic training for medical students, further underscoring the novelty and relevance of this research.
Methods: An anonymous survey was distributed to WSUSOM students who attended one or more medical Arabic workshops. The survey utilized a five-point Likert scale (1 = never, 5 = always) to assess domains such as communication confidence, comprehension preparedness, and perceived training utility. A total of 119 students completed the pre-workshop survey, and 110 completed the post-workshop survey. Unpaired t-tests were used to compare weighted averages across domains before and after the workshops, with p-values \u3c 0.05 considered significant.
Results: Participation in the medical Arabic workshops was associated with statistically significant improvements in students\u27 confidence and preparedness when interacting with Arabic-speaking patients. Pre-workshop, the weighted average score for confidence in understanding Arabic in clinical settings was 2.18 (SD = 1.34), which increased to 3.14 (SD = 1.15) post-workshop (p \u3c 0.0001). Similarly, students\u27 confidence in communicating health information rose from an average of 2.10 (SD = 1.21) to 3.17 (SD = 1.09) after attending the workshops (p \u3c 0.0001). Additionally, the proportion of students reporting regular use of Arabic in clinical encounters remained high, but post-workshop responses indicated a reduction in the frequency with which students needed clarification during patient interactions. Overall, the majority of participants agreed that the workshops enhanced their clinical skills and preparedness to serve Arabic-speaking patients.
Conclusions: Medical Arabic workshops effectively improved medical students\u27 confidence and readiness to engage with Arabic-speaking patients. These findings suggest that targeted language and cultural competency training may enhance communication and clinical performance, and that integration of similar programs into the formal medical school curriculum could help address language barriers in patient care