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Perfusion Index to Predict the Occurrence of Hypotension following Spinal Anaesthesia for Lower Segment Caesarean Section
No full textStudy to Determine the Effect of Oral Pregabalin as Premedication on Hemodynamic Response to Laryngoscopy, Endo- racheal Intubation and Carbo-Peritoneum during Elective Laparoscopic Surgeries under General Anaesthesia
No full textDistribution of Virulence and Antimicrobial Resistance Determinants in Shigella Spp.
No full textThe study describes the species trends and the antimicrobial susceptibility profile of the isolates. The presence of virulence, antimicrobial resistance determinants and its
associated mobile genetic elements was analyzed. The study also evidenced the evolution and expansion of the drug-resistant strains in India through phylogenetic analysis.
The study demonstrates the emergence of antimicrobial resistant Shigella spp in India. Further, co-presence of third-generation cephalosporins and quinolone resistance
genes indicate the potential threat of resistance dissemination to these antimicrobials. The presence of plasmid carrying azithromycin resistance gene in one of the studies isolates further underlines the risk of emerging resistance to this drug on continuous exposure. The
study findings also evidenced the ability of the Shigella spp in AMR acquisition through HG. In this study, heterogeneity of virulence determinants among Shigella serogroups was observed, which improved our knowledge on the contribution of various virulence factors in disease severity. Besides, the study demonstrated the role of whole genome sequencing in several aspects, this includes i) identification of non-serotypeable Shigella spp ii)
identification of virulence and resistance determinants iii) identification and characterization of MGEs associated with AMR iv) prediction of evolution and expansion of drug resistant lineage through SNP based phylogenetic analysis. These highlights the importance of Shigella surveillance in our settings. Mainly the local distribution of Shigella
serotypes remains important as humans demonstrate only serotype-specific immunity.
Future Recommendations:
Continuous surveillance on changing trend of antimicrobial susceptibility of this pathogen is essential for effective treatment particularly in Shigella endemic regions.
• Whole-genome sequencing of all serogroups/serotypes of Shigella is needed for the identification of new variants.
• Surveillance of mobile genetic elements among enteric pathogens is essential to map the exchange of AMR genes in the gut microbiota and to manage the spread of drug-resistant strains.
• Genomic surveillance studies are required to monitor the evolutionary trends and genome dynamics of emerging and existing resistance clones of Shigella spp.
• Further, gut microbiome studies could reveal the composition of microbiomerelated to Shigella infection which provides us the knowledge on the successful survival of this as a human pathogen
A Study to Assess the Effect of Critical Pathway as Preventive Strategy on Medication Errors Upon the Level of Knowledge, Practice and Reduction of Medication Errors among Nurses at Apollo Speciality Hospitals, Chennai
No full textVisual Evoked Potential and Optical Coherence Tomography Analysis in Traumatic Optic Neuropathy
No full textAssociation between Glycosylated Hemoglobin and Intraocular Pressure in Patients with Diabetes Mellitus
No full textEvaluation of Retinal Nerve Fibre Layer Thickness with Optical Coherence Tomography as a Predictor for Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
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