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Study on Role of Enzyme Immune Assay(EIA) in Detection of Chlamydial Antigen in Female Patients with Cervicitis
No full textA Cross Sectional study on Utilization of Post Natal Care Services in Rural Areas of Theni District
No full textA Cross Sectional study on Factors Influencing Consumption of Iron and Folic Acid Tablets among Antenatal Mothers in Rural Area of Thanjavur District
No full textStudy of Cluster-B Personality Traits and Disorders among Patients with Dissociative Conversion Disorder
No full textSituational Analysis of Diagnosis and Treatment Outcome of Tuberculous Meningitis in Tertiary Care Hospital
No full textA Study on Role of Tranexxamic Acid in Reducing Blood Loss in Normal Labour
No full textBACKGROUND:
Though labour is a physiological process it is associated with maternal morbidity and mortality. A life-threatening obstetric hemorrhage occurs in around 1 in 1000 deliveries. Efforts to prevent and minimize maternal morbidity and death related to PPH may help to close the gap in maternal health outcomes that exists throughout the world. Thus, this study was aimed to determine the efficacy of Tranexamic acid in reducing post-partum blood loss after normal vaginal delivery. The changes in the fibrinolytic components during and immediately after placental delivery are consistent with fibrinolysis which occurs as a response to local fibrin deposition which in turn occurs as a result of tisssue damage. Hence there occurs a decrease in fibrinogen level and increase in fibrinogen degradation products. Tranexamic acid is a Competitive inhibitor of plasminogen activator. It prevents Fibrin degradation & preserving the framework of fibrin matrix structure. Hence Tranexamic acid, an anti fibrinolytic agent is used to reduce blood loss after normal delivery with an aim to decrease the incidence of excessive blood loss after delivery.
METHODS:
This study is conducted among patients admitted in labour ward of Government Villupuram Medical College and Hospital for normal vaginal delivery. Study population are divided into 2 groups as follows, each having 60. The study group and the control group are treated as per Standard AMTSL protocol with along with Inj. Tranexamic acid 1gm iv infusion in 100 ml NS over 15 minutes period after delivery of baby in study group alone. In each case, the parameters like pre delivery vitals, blood loss during delivery, post-partum vitals, pre and post delivery hemoglobin, PCV along with the need for post-partum blood transfusion and their duration of hospital stay were noted.
RESULTS:
120 patients were selected for the study, 60 as study group and 60 as control group. 50% of the cases belonged to the age group 20-24.75% of the cases belonged to class V socioeconomic Status. 30% of the cases were primi gravida and 70% of the cases were 2nd gravida 80% of the cases were booked cases.
Among the study population, in study group the mean height was 154.28 ± 1.9, the mean weight was 55.27 ± 1.83, the mean BMI was 23.21 ± 0.63 and in control group the mean height was 153.78 ± 1.74, the mean weight was 55.18 ± 1.71, the mean BMI was 23.33 ± 0.64. Among the study population, in study group 46 (76.67%) of them parity were 2nd gravida, 14 (23.33%) of them parity were primi and in control group, 43 (71.67%) of them parity were 2nd gravida, 17 (28.33%) of them parity were primi. The difference in proportion between 2 groups with respect to anthropometry, parity, induction of labour, mode of delivery were not statistically significant. Tranexamic acid significantly reduced the blood loss, need for additional uterotonics and maternal blood transfusion in the study group compared to the control group. The duration of stay was found to be reduced in the study group when compared to control group. The incidence of vomiting, shivering, fever were statistically insignificant. There was statistically significant fall in systolic blood Pressure and rise in PR in the control group compared to the study group post delivery.
CONCLUSION:
Parentral Tranexamic acid injection, an antifibrinolytic agent given prophylactically at the time of delivery have proven to reduce the blood loss during normal labour and reduces maternal morbidity. As TXA readily available hemostatic agent we strongly suggest that it should be further investigated as an adjuvant treatment in PPH prophylaxis
Comparative study on Laser Hemorrhoidectomy and Open Hemorrhoidectomy in Patients with Grade III and Grade IV Hemorrhoids: A Prospective Randomized study
No full text
