ePrints@TNMGRM (Tamil Nadu Dr. M.G.R. Medical University)
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Effects of Co2 Pneumoperitoneum on Coagulation Profile in Patients Under Going Laparoscopic Cholecystectomy in a Tertiary Care Centre
No full textA Descriptive study on Role of Pleural Fluid C-Reactive Protein in Pleural Effusions
No full textBACKGROUND: The pleural cavity, also known as the pleural effusion, is where fluid collects between both the parietal and visceral pleura which can develop independently or as a result of another parenchymal disease, such as an infection, cancer, or inflammatory diseases. The use of pleural fluid CRP in diagnosing exudative pleural effusion has been the subject of numerous studies undertaken all over the world. However, there are only a few studies with small samples that are available from India, so this study was done to determine the effectiveness of pleural fluid CRP as a biomarker for differentiating between exudative and transudative pleural effusions.
AIM OF THE STUDY:
To determine the role of pleural fluid C – reactive protein in pleural effusion and its aetiology.
OBJECTIVES:
1. To determine the role of pleural fluid C – reactive protein in pleural effusion.
2. To assess the diagnostic value of pleural fluid C – reactive protein in pleural effusion differentiating exudative from transudative effusion.
3. To evaluate the position of CRP in the diagnostic algorithm of pleural effusion.
METHODS: A observational study was done in a tertiary care centre among 88 patients with pleural effusion to determine their CRP levels. The data were analyzed using descriptive and inferential statistics of CRP in pleural effusion to differentiate exudative and transudative effusion.
RESULTS: The pleural fluid CRP level was higher in exudative than transudative effusion. The AUC was 0.995 in the differentiation of exudative from transudative effusion (cut off value 43.4) using Pleural fluid CRP levels.
CONCLUSION: The pleural fluid CRP was a potential biomarker in differentiating exudative from transudative effusions
A Randomised Control Trial study on Prevention of Flap Necrosis in Modified Radical Mastectomy Wound with Topical Diltiazem
No full textComparative study Between Mass Closure Suturing Technique and Hughes Repair in Emergency Midline Laparatomies
No full textA Prospective study Comparing the Harmonic Focus and Traditional Suture Ligation Technique in Open Thyroidectomy
No full textA Cross Sectional study to Observe the Proportion of the Microbiological Sub-types of Necrotising Soft Tissue Infections in a Tertiary Care Center in South India
No full textA Comparison study on Bile Leak following Laparoscopic Cholecystectomy with Loop Closure Versus Clip Closure of the Cystic Duct
No full textA Randomised Controlled Trial on Wound Probing of Contaminated Wounds and Its Impact on Wound Infection
No full textElectrocardiogram Changes in Patients with Acute Ischaemic Stroke and Correlation with Serum Homocysteine to Predict Mortality
No full textINTRODUCTION:
Cerebrovascular disease is the second leading cause of death worldwide
following ischaemic heart disease. It is responsible for 11% of total deaths
worldwide. It also causes significant morbidity and disability, often
endangering the livelihoods of young and working class people. Ischaemic heart
disease (IHD) and cerebrovascular disease (CVA) share several risk factors such
as hypertension, diabetes mellitus, dyslipidaemia and smoking.
These risk factors are modifiable. Some newer biomarkers for inflammation
also correlate with higher risk of both ischaemic heart disease and
cerebrovascular accidents such as homocysteine levels, C- reactive protein, etc.
Patients with acute CVA may have underlying IHD which may predispose them
to CVA due to embolic phenomenon as a result of atrial fibrillation or mural
thrombus from left ventricular aneurysm. Evidence of such cardiac
abnormalities is easily evident on a simple 12 lead electrocardiogram (ECG). On the other hand, CVA can produce certain changes in the function of the heart due to the sympathetic storm that accompanies it, a phenomenon known as Neurogenic Stunned Myocardium (NSM). Catecholamines produce
myocardial injury in the form of myocytolysis and myofibrillar degeneration that is distinct from myocardial necrosis caused by IHD. Some studies have tried to correlate the site of lesion in ischaemic stroke to ECG changes.
Ischaemic lesions associated with the insular cortex have been known to cause autonomic dysregulations and poor cardiac outcome. Hence, many researchers have tried to associate the site of lesions to ECG changes.
OBJECTIVE: To determine the relationship between serum homocysteine levels and electrocardiographic changes in patients with acute ischaemic stroke on one month mortality.
METHOD: 101 patients with acute ischaemic stroke admitted in the months April to September in 2022 were enrolled and followed up for one month. Serum homocysteine levels and ECG changes were studied. Disability and mortality at one month was assessed.
RESULT: ECG abnormalities were present in 25.6% (n=26). Severely elevated homocysteine levels were present in 49.5% (n=50). ECG abnormalities were less likely to be associated with risk of death in stroke (RR=0.488) in our study and severely elevated homocysteine levels were associated with high risk of death from stroke (RR=5.6). Combined ECG abnormalities and homocysteine levels were strong predictors of mortality in stroke. Higher homocysteine levels correlated with large vessel occlusion.
CONCLUSION: Screening for homocysteine levels in stroke irrespective of age can serve as a mortality predictor and can serve as a basis for folic acid supplementation for stroke prevention
A Study of Serum Total Calcium and Calcium Phosphorus Ratio in Primary Hypertension and Its Role Predicting the Severity of the Disease
No full textINTRODUCTION: Hypertension significantly increases the risk of mortality and morbidity of cerebrovascular accidents (ischemic and hemorrhagic) coronary artery disease, congestive heart failure, chronic kidney failure, and peripheral vascular diseases. Hypertension related complications have become one of the most important contributor to preventable deaths and diseases in our country too, with an alarmingly increasing rate in the rural areas. More than 140 million people are said to be suffering from hypertension in India.
AIMS AND OBJECTIVES:
1.To study the levels of serum calcium and calcium phosphorus ratio in patients with primary hypertension.
2.to correlate serum calcium and calcium /phosphorus ratio with blood pressure.
STUDY POPULATION
A total of 102 subjects of primary hypertension satisfying inclusion and exclusion criteria visiting medicine OPD in Govt. Kilpauk Medical College and Hospital.
SETTINGS AND DESIGN:
A cross sectional study involving 102 subjects. Concentrations of serum total calcium and serum calcium phosphorus ratio were measured in the participants.
RESULTS:
The study showed that serum total calcium were significantly reduced and calcium phosphorus ration were increased which caused the cardiovascular morbidity.
CONCLUSIONS:
Primary hypertension has an inverse association with serum total calcium and negative correlation with calcium phosphorus ratio which suggests a no role in the pathogenesis of essential hypertension