E-Journal Faculty of Medicine Universitas Padjadjaran / E-Jurnal Fakultas Kedokteran Universitas Padjadjaran
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Perbandingan Nilai rSO2 Pra dan Pasca Pembedahan Bedah Kraniotomi Tumor Removal Di RSUP Haji Adam Malik Medan
No full textPengukuran regional oxygen saturation (rSO2) menggunakan near- infrared spectroscopy (NIRS) berkorelasi dengan saturasi vena sentral. Oksigen serebral sangat dipengaruhi oleh autoregulasi serebri yang dapat mengatur aliran darah ke otak sehingga menyebabkan oksigen dapat bertambah maupun berkurang. Penelitian ini bertujuan melihat perbandingan nilai rSO2 pre dengan pascabedah kraniotomi tumor removal di RSUP Haji Adam Malik Medan. Penelitian ini merupakan jenis penelitian cohort prospective. Penelitian ini dilakukan pada 12 pasien yang menjalani prosedur pembedahan kraniotomi tumor removal selama 14 April–19 Mei 2023 Sampel dipilih menggunakan metode consecutive sampling. Analisis data menggunakan uji t berpasangan. Sebanyak 12 pasien diteliti rSO2 sebelum operasi kraniotomi didapatkan rerata sebesar 64,50±2,98 pada kanan dan kiri didapatkan rerata sebesar 62,58±3,17. Pada rSO2 setelah operasi kraniotomi didapatkan rerata sebesar 71,58±2,31 pada kanan dan kiri didapatkan rerata sebesar 70,25±3,52. Pada rSO2 kanan rerata sebesar 64,50±1,90 dan rSO2 kanan sesudah penelitian ini didapatkan rerata sebesar 71,58±1,71 dengan nilai p<0,05 secara statistik terdapat perbedaan bermakna antara rSO2 kanan sebelum dan sesudah operasi. Simpulan, terdapat perbedaan antara rSO2 sebelum dan sesudah pembedahan kraniotomi tumor removal di RSUP Haji Adam Malik, Medan. AbstrakLatar Belakang : Pengukuran rSO2 menggunakan NIRS berkorelasi dengan saturasi vena sentral. Oksigen serebral sangat dipengaruhi oleh autoregulasi serebri yang dapat mengatur aliran darah ke otak sehingga menyebabkan oksigen bisa bertambah maupun berkurang.Tujuan: Penelitian ini bertujuan untuk melihat perbandingan nilai rSO2 pra dan pasca pembedahan Kraniotomi Tumor Removal di RSUP Haji Adam Malik Medan.Metode: Penelitian ini merupakan jenis penelitian cohort prospective. Penelitian ini dilakukan pada 12 pasien yang menjalani prosedur pembedahan Kraniotomi Tumor removal. Sampel dipilih menggunakan metode consecutive sampling. Analisa data menggunakan uji T Berpasangan.Hasil: Sebanyak 12 pasien diteliti rSO2 sebelum operasi kraniotomi didapatkan rerata sebesar 64,50 ± 2,98 pada kanan dan kiri didapati rerata sebesar 62,58 ± 3.17. Pada rSO2 sebelum operasi kraniotomi didapatkan rerata sebesar 71,58 ± 2.31 pada kanan dan kiri didapati rerata sebesar 70,25 ± 3.52. Pada rSO2 kanan rerata sebesar 64,50 ± 1,90 dan rSo2 kanan sesudah penelitian ini didapati rerata sebesar 71,58 ± 1.71 didapatkan nilai < 0,05, secara statistik terdapat perbedaan bermakna antara rSO2 kanan sebelum dan sesudah operasi.Kesimpulan: Terdapat perbedaan yang bermakna antara rSO2 sebelum dan sesudah pembedahan bedah kraniotomi tumor removal di RSUP Haji Adam Malik MedanKata Kunci: nilai rSO2, kraniotomi, tumor removal
Detection of Leptospira sp. Bacteria and Factors Related to the Incidence of Leptospirosis in Semarang City
Get PDFObjective: The Case Fatality Rate (CFR) of Leptospirosis in Semarang City has shown a tendency to increase from 2019 to 2022. In 2022, there were 30 cases reported, with 8 deaths (CFR 27%). The purpose of this study was to detect Leptospira sp. bacteria in rats and analyze the risk factors for leptospirosis in Semarang City.Methods: This study employed an observational approach with a Case-Control Study design. The research was conducted in Semarang City from November to December 2023. Non-random sampling techniques were used, specifically the total sampling method, resulting in a sample size of 45 case groups and 45 control groups. Bivariate analysis was performed using the Chi-square test, with a significance level set at <0.05.Results: Based on the Chi-Square test results, the following variables were found to be associated with the incidence of leptospirosis in Semarang City: the presence of rats (p<0.0001), the presence of Leptospira sp. bacteria (p<0.0001), house conditions (p=0.260), sewer condition (p<0.0001), presence of pets (p=0.001), condition of landfills (p=0.001), presence of vegetation (p=0.005), temperature (p=0.299), humidity (p=0.495), lighting (p=0.023), history of wounds (p=0.001), and knowledge level (p=0.025).Conclusion: The risk factors for leptospirosis in Semarang City include the presence of rats, the presence of Leptospira sp. bacteria, sewer conditions, the presence of pets, conditions of landfills, the presence of vegetation, lighting, history of injury, and level of knowledge
Relationship between BMI and Urine pH in Nephrolithiasis Cases in Indonesia
Get PDFIn nephrolithiasis/urolithiasis, urine pH is thought to modulate kidney stone formation at various stages, including crystallization, growth, aggregation, and retention. Moreover, numerous studies have demonstrated that an increase in Body Mass Index (BMI) correlates with a decrease in urine pH. This study aimed to determine the relationship between BMI and urine pH in cases of nephrolithiasis at Dr. Hasan Sadikin General Hospital Bandung. This was analytical observational study with a cross-sectional design, followed by correlation analysis is carried out. A total of 100 patients from January 2021 to December 2022 have met the inclusion criteria. From the results of the analysis, it was discovered that of the 21 patients with acidic urine pH, 42.11% had normal BMI, 26.32% were grade 1 obese, 15.79% were grade 2 obese, 10.53% were overweight, and 5.26% were underweight. The majority of patients who had normal urine pH also had a normal BMI (34.18%), followed by 30.38% with grade 1 obesity, 21.52% with grade 1 obesity, and 13.92% with grade 2 obesity. Of the 2 patients with alkaline urine pH, one person had a normal BMI and another had an overweight BMI. The results of the chi-square test presented a p value of >0.05, thus no significant relationship is observed between urine pH and BMI in nephrolithiasis patients
Concordance between Isothermal Amplification-Real Time Fluorescence Assay and Reverse Transcriptase Real Time Polymerase Chain Reaction for Detecting SARS-CoV-2
Get PDFBackground: There are various nucleic-acid-based diagnostic tests used to detect SARS-CoV-2 in COVID-19 patients such as reverse transcription polymerase chain reaction (RT-PCR) and isothermal amplification real time fluorescence assay (IARTFA), with the first-mentioned is considered as the gold standard. The IARTFA is an alternative method using cross priming amplification (CPA) technique under constant temperature, with a simpler procedure and faster result. This study aimed to determine the concordance between IARTFA and RT-PCR in detecting SARS-CoV-2.Methods: This was an observational cross-sectional study with a random sampling method, conducted from August-October 2021 in Dr. Hasan Sadikin General Hospital, Bandung. Data on patients was obtained from medical records. Cohen's kappa test was used to determine concordance between both methods.Results: A total of 30 subjects were collected, including subjects with positive result on RT-PCR and IARTFA (n=15), negative result on both methods (n=5), and with positive result on RT-PCR but negative on IARTFA (n=10). There were discrepancies between both methods in subjects with cycle threshold (CT) values ≥35. However, there was a significant concordance between both methods (Cohen’s kappa coefficient of 1, p = 0.006).Conclusion: In addition to RT-PCR, IARTFA is an alternative method for detecting SARS-CoV-2 with advantages and excellent concordance. In communicable diseases such as COVID-19, along with healthy lifestyles such as isolation and wearing masks, early diagnosis is important to prevent and manage the spread of the disease
Blood Pressure Reduction in Patients with Hypertension Through Soursop Leaf Tea Consumption
Get PDFBackground: Controlling hypertension through pharmacological treatment is effective but can potentially lead to long-term side effects. Thus, more patients with hypertension have turned to herbal plants for treatment. The objective of this study was to examine the effectiveness of soursop leaf tea in reducing blood pressure in patients with hypertension.Methods: This study employed a quasi-experimental approach with a non-randomized pretest-posttest control group design, involving 30 participants in the intervention group and 30 participants in the control group. Data was analyzed using the Wilcoxon test to assess the disparity in mean blood pressure levels before and after consumption of soursop leaf tea. The Mann-Whitney test was used to examine the distinction in mean blood pressure between the intervention group and the control group.Results: In the intervention and control groups, most respondents were aged 56–65 years (60% and 66.7%), male (70% and 56.7%) and had suffered from hypertension for more than 5 years (70% and 56.7%). There was a significant difference in systolic blood pressure (p<0.001) and diastolic blood pressure (p<0.001) before and after the administration of soursop leaf tea. The mean systolic and diastolic blood pressure in the intervention group decreased significantly compared to the control group (p<0.001).Conclusions: Consumption of soursop leaf tea can reduce systolic and diastolic blood pressure, suggesting that this local herb has a potential effect on individuals diagnosed with hypertension
PERBANDINGAN TEKNIK PEMASANGAN PIPA NASOGASTRIK ANTARA MANUVER REVERSE SELLICK DENGAN MANUVER FLEKSI LEHER TERHADAP ANGKA KEBERHASILAN DAN DURASI WAKTU PEMASANGAN PADA PASIEN TERINTUBASI DI RSUP DR. HASAN SADIKIN BANDUNG
No full textPemasangan pipa nasogastrik (NGT) penting dilakukan pada beberapa pembedahan dan pada pasien di ruang rawat intensif (ICU). Pemasangan NGT menjadi sulit pada pasien terintubasi dan paling sering tertahan pada sinus priformis, kartilago aritenoid, dan esofagus yang tertekan oleh balon ETT. Manuver reverse Sellick merupakan teknik yang dilakukan dengan cara menggenggam kartilago krikoid lalu diangkat ke arah anterior dan manuver fleksi leher merupakan suatu cara menekukkan leher pasien semaksimal mungkin pada saat memasang NGT. Penelitian ini menggunakan metode prospektif analitik komparatif eksperimental dengan rancangan randomized clinical trial single blind study. Penelitian telah dilakukan di RSUP Dr. Hasan Sadikin Bandung (RSHS) terhadap 94 subjek. Analisis statistik data kategorik menggunakan Uji Chi Square dan uji normalitas dengan menggunakan Kolmogorov smirnov. Hasil uji statistik perbandingan tingkat keberhasilan pada kelompok manuver reverse Sellick dan kelompok manuver fleksi leher adalah 85,1% dan 74,5% dengan perbedaan yang tidak bermakna (p>0,05). Durasi pemasangan NGT pada kelompok manuver reverse Sellick dan kelompok manuver fleksi leher adalah 13,499±1,571 detik dan 20,5,06±3,051 detik dengan perbedaan signifikan (p0,05) dan Durasi pemasangan NGT pada kelompok manuver reverse sellick dan kelompok manuver fleksi leher adalah 13,499 ± 1,571 detik dan 20,5,06 ± 3,051 detik dengan perbedaan signifikan (p<0,05; Tabel 4.2). Simpulan dari penelitian ini yaitu Manuver reverse sellick memiliki tingkat keberhasilan pada pemasangan pertama lebih tinggi dan durasi pemasangan yang lebih singkat daripada teknik fleksi leher. Kata kunci: Angka keberhasilan; durasi waktu pemasangan; manuver fleksi leher; manuver reverse sellick; pemasangan NG
Correlation Between CA 15-3 And Miller Payne Histopathological Response In Locally Advanced Breast Cancer Undergoing FAC Regiment Neoadjuvant Chemotherapy
Get PDFResponse to chemotherapy for breast cancer can be assessed using the CA 15-3 tumor marker, or through histopathological means such as Miller Payne assessment. This study aimed to explore the correlation between CA 15-3 level and histopathological response in locally advanced breast cancer. This is a cross-sectional study measuring CA 15-3 before and after neoadjuvant chemotherapy using the FAC regiment. This study took place in Dr. Hasan Sadikin Hospital Bandung, Indonesia, from January to August 2022. Data on histopathological responses before chemotherapy and after surgery were also collected. Thirty-nine patients were admitted as subjects. Most patients had invasive carcinoma of no special type (79.5%) and luminal B HER 2 molecular subtype (38.5%). A significant decrease in CA 15-3 level after chemotherapy (from 23.54±18.38 ng/ml to 16.30±6.51 ng/mL) was observed. No significant correlation between CA 15-3 level and Miller Payne histopathological responses were found in the subjects
Self-Medication using Chlorpheniramine Maleate in Karanganyar Regency, Central Java, Indonesia
Get PDFSelf-medication refers to the use of medications by a person without consulting health professionals and prescription. One of the common drugs used for self-medication is chlorpheniramine maleate (CTM), a drug indicated to relieve symptoms of allergy. However, the lack of knowledge about the indications of CTM leads to its significant misuse. Long-term effects of CTM misuse include heart rate regularity disorder, central nervous system disorders, and even coma. The purpose of this study was to analyze the correlation between sociodemographic factors and the appropriateness of CTM use for self-medication from the perspective of the experience of using CTM for self-medication. This cross-sectional study was performed in Karanganyar Regency, Central Java, Indonesia, from October to November 2022 on 117 respondents sampled randomly using cluster sampling method. A questionnaire that was already proven as valid and reliable was used. Results for the appropriateness of CTM use showed that 95.7% of respondents were in good category, 3.4% were in fair category, and 0.9% were in poor category. The hypothesis tests, which were the Somers’d test and the contingency coefficient, showed no correlation between age (p=0.242), gender (p=0.307), income level (p=0.789), experience (p=0.176), and the appropriate use of CTM for self-medication. However, there is a correlation between education level (p=0.048) and the appropriate use of CTM for self-medication, albeit very weak (r=0.065). Therefore, only the level of education affects the appropriate use of CTM for self-medication
Overview of Non-Pharmacological Treatment Option for Adolescent Girls with Dysmenorrhea in Cimahi, West Java, Indonesia
Get PDFBackground: Dysmenorrhea is a condition of pain during menstruation that may affect daily activities. The phenomenon of dysmenorrhea in West Java has reached 54,9%. When dysmenorrhea is not treated, it can decrease productivity at school. This study aimed to find out which therapy was more widely used, the reasons for using the therapy, and to identify changes in non-pharmacological therapy as seen from the visual analog scale (VAS) assessment.Methods: This research used quantitative data with a descriptive study conducted with a cross-sectional method, and the instrument used was a questionnaire. The study was conducted in July 2022 with a total sample of 457 participants, and 366 samples met the inclusion criteria. This data analysis used Statistical Package for Social Scientists (SPSS version 28) to identify changes before and after non-pharmacological therapy options and the frequency distribution of the data.Results: The non-pharmacological therapy option was preferred by students (n= 366), and the reasons students used this therapy were seen from various aspects. Rest was the most frequently chosen activity by students (n= 329). All students felt a change in the pain scale before and after using non-pharmacological therapy with the visual analog scale (VAS).Conclusion: Students in grades 1 and 2 of SMAN 1 Cimahi prefer non-pharmacological therapy with rest. They have various aspects of reasoning and feeling changed after using the therapy. There is a change in the pain scale after using non-pharmacological therapy