727 research outputs found
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Key Signature Genes of Early Terminal Granulocytic Differentiation Distinguish Sepsis from SIRS on ICU Admission
No full textBackground: Infection can induce granulopoiesis. This process potentially gives rise to blood gene classifiers of sepsis in systemic inflammatory response syndrome (SIRS) patients. The aim of this study was to identify sepsis signature genes in blood granulocytes from patients with sepsis and SIRS on intensive care unit (ICU) admission.
Methods: CD15+ cells encompassing all stage of terminal granulocytic differentiation were analyzed. CD15 transcriptomes from patients with sepsis and SIRS on ICU admission and presurgical controls (discovery cohort) were subjected to differential gene expression and pathway enrichment analyses. Differential expression was validated by bead array in independent sepsis and SIRS patients (validation cohort). We referred to the GeneCards database for subcellular gene associations and Grassi et al. (Cell Rep 2018; 24: 2784-2794) for granule signature genes. Blood counts of granulocyte precursors were determined by flow cytometry in a validation cohort subset.
Results: Despite similar transcriptional CD15 responses in sepsis and SIRS, enrichment of pathways known to decline at the metamyelocyte stage (mitochondrial, lysosome, cell cycle, proteasome) was associated with sepsis but not SIRS. Twelve of 30 validated genes, from 100 selected for changes in response to sepsis rather than SIRS, were endo-lysosomal. Revisiting the discovery transcriptomes revealed elevated expression of promyelocyte-restricted azurophilic granule genes in sepsis and myelocyte-restricted specific granule genes in sepsis followed by SIRS. Blood counts of promyelocytes and myelocytes were higher in sepsis than SIRS.
Conclusions: Sepsis-induced granulopoiesis and signature genes of early terminal granulocytic differentiation provide a rationale for classifiers of sepsis in patients with SIRS on ICU admission. Yet, distinction of this process from non-infectious tissue injury-induced granulopoiesis remains to be investigated
[2+3] Amide Cages by Oxidation of [2+3] Imine Cages - Revisiting Molecular Hosts for Efficient Nitrate Binding [Data]
No full textThe pollution of groundwater with nitrate is a serious issue because nitrate can cause several diseases such as methemoglobinemia or cancer. Therefore, selective removal of nitrate by efficient binding to supramolecular hosts is highly desired. Here we describe how to make [2+3] amide cages in very high to quantitative yields by applying an optimized Pinnick oxidation protocol for the conversion of corresponding imine cages. By NMR titration experiments of the eight different [2+3] amide cages with nitrate, chloride and hydrogen sulfate we identified one cage with an unprecedented high selectivity towards nitrate binding vs chloride (S = 446) or hydrogensulfate (S >13000). NMR experiments as well as single-crystal structure comparison of host-guest complexes gave insight into structure property relationships
Economic impacts of oral diseases in 2019 - data for 194 countries
No full textData for the global, regional, and country-level economic impacts of oral diseases in 2019.
Methodology is based on:
(1) Listl S, Galloway J, Mossey PA, Marcenes W. Global Economic Impact of Dental Diseases. J Dent Res. 2015;94:1355-61.
(2) Righolt AJ, Jevdjevic M, Marcenes W, Listl S. Global-, Regional-, and Country-Level Economic Impacts of Dental Diseases in 2015. J Dent Res. 2018 May;97(5):501-507
Activity of AcD and nonAcD cells during high-frequency network oscillations [data]
No full textInformation processing in neuronal networks involves the recruitment of selected neurons into coordinated spatiotemporal activity patterns. This sparse activation results from widespread synaptic inhibition in conjunction with neuron-specific synaptic excitation. We report the selective recruitment of hippocampal pyramidal cells into patterned network activity. During ripple oscillations in awake mice, spiking is much more likely in cells in which the axon originates from a basal dendrite rather than from the soma. High-resolution recordings in vitro and computer modeling indicate that these spikes are elicited by synaptic input to the axon-carrying dendrite and thus escape perisomatic inhibition. Pyramidal cells with somatic axon origin can be activated during ripple oscillations by blocking their somatic inhibition. The recruitment of neurons into active ensembles is thus determined by axonal morphological features
Synthesis of Large [2+3] Salicylimine Cages with Embedded Metal-Salphen Units [Data]
No full textShape-persistent trinuclear Ni(II)- and Pt(II)-cage compounds with large cavities have been synthesized by using bissalicylaldehyde struts that contain the metal salphen units already. The Pt(II) derivative was investigated by single crystal X-ray diffraction
Patients’ willingness to provide their clinical data for research purposes and acceptance of different consent models. Findings from a representative survey of cancer patients in Germany [Research Data]
No full textThis is the research data of the publication "Patients’ willingness to provide their clinical data for research purposes and acceptance of different consent models. Findings from a representative survey of cancer patients in Germany." The research data includes the questionnaire, the data set used, and a description of the data preparation
CARDIO:DE [V1.1.2]
No full textVersion information
CARDIO:DE 1.1.2
Minor formatting updates
(Previous version: CARDIO:DE 1.1.1)
Abstract:
We present CARDIO:DE, the first freely available and distributable large German clinical corpus from the cardiovascular domain. CARDIO:DE encompasses 500 clinical routine German doctor’s letters from Heidelberg University Hospital, which were manually annotated. Our prospective study design complies well with current data protection regulations and allows us to keep the original structure of clinical documents consistent. In order to ease access to our corpus, we manually de-identified all letters. To enable various information extraction tasks the temporal information in the documents was preserved. We added two high-quality manual annotation layers to CARDIO:DE, (1) medication information and (2) CDA-compliant section classes. To the best of our knowledge, CARDIO:DE is the first freely available and distributable German clinical corpus in the cardiovascular domain. In summary, our corpus offers unique opportunities for collaborative and reproducible research on natural language processing models for German clinical texts.
If you make use of the corpus, please cite the following resource:
Richter-Pechanski, P. et al. CARDIO:DE. heiData https://doi.org/10.11588/data/AFYQDY (2022).
If you cite the related manuscript published at Scientific Data, please cite:
Richter-Pechanski, P., Wiesenbach, P., Schwab, D.M. et al. A distributable German clinical corpus containing cardiovascular clinical routine doctor’s letters. Sci Data 10, 207 (2023). https://doi.org/10.1038/s41597-023-02128-9.
CARDIO:DE contains manual gold standard annotations of:
medication information (ActiveIng, Dosage, Drug, Duration, Form, Frequency, Reason, Route, Strength)
section types (Abschluss, Anamnese, Anrede, Diagnosen, AufnahmeMedikation, Befunde, EchoBefunde, AktuellDiagnosen,
EntlassMedikation, KuBefunde, Labor, Mix, AllergienUnverträglichkeitenRisiken, Zusammenfassung)
Information about how to access the data, see Terms -> Terms of Use section.</b
What Drives Engagement in the Clean Energy Ministerial? An Assessment of Domestic-Level Factors [Dataset]
No full textThis study concentrates on the Clean Energy Ministerial (CEM) as one of several high-level global forums on climate change governance. The CEM can be conceptualised as a ‘polycentric’ organisation in which its members collaborate on a wide range of issues concerning the clean energy transition. Can we identify a set of domestic-level variables that explain the member states’ participation across different CEM initiatives? And can we identify clusters of CEM initiatives for which the same set of domestic-level variables provide robust explanations? Theoretically, we concentrate on domestic factors and how these explain engagement patterns in high-level global forums. Our findings for 12 initiatives show that there is no single domestic factor that explains engagement levels equally well for all CEM initiatives. Our overarching finding is that the domestic determinants of engagement vary across the initiatives, suggesting that future research should attend more closely to their specific features
3D Point Cloud from Nakadake Sanroku Kiln Site Center, Japan: Sample Data for the Application of Adaptive Filtering with the AFwizard
No full textThis data set represents 3D point clouds acquired with LiDAR technology and related files from a subregion of 150*436 sqm in the ancient Nakadake Sanroku Kiln Site Center in South Japan. It is a densely vegetated mountainous region with varied topography and vegetation. The data set contains the original point cloud (reduced from a density of 5477 points per square meter to 100 points per square meter), a segmentation of the area based on characteristics in vegetation and topography, and filter pipelines for segments with different characteristics, and other data necessary. The data serve to test the AFwizard software which can create a DTM from the point cloud with varying filter and filter parameter selections based on varying segment characteristics (https://github.com/ssciwr/afwizard).
The AFwizard adds flexibility to ground point filtering of 3D point clouds, which is a crucial step in a variety of applications of LiDAR technology. Digital Terrain Models (DTM) derived from filtered 3D point clouds serve various purposes and therefore, rather than creating one representation of the terrain that is supposed to be "true", a variety of models can be derived from the same point cloud according to the intended usage of the DTM.
The sample data were acquired during an archaeological research project in a mountainous and densely forested region in South Japan -- the Nakadake-Sanroku Kiln Site Center: LiDAR data were acquired in a subregion of 0.5 sqkm, a relatively small area characterized by frequent and sudden changes in topography and vegetation. The point cloud is very dense due to the technology chosen (UAV multicopter GLYPHON DYNAMICS GD-X8-SP; LiDAR scanner RIEGL VUX-1 UAV).
Usage of the data is restricted to the citation of the article mentioned below.
Version 2.01: 2023-05-11; Article citation updated; 2022-07-21; Documentation (HowTo - Minimal Workflow) updated, data files tagged
Electron-beam lithography of cinnamate polythiophene films: conductive nanorods for electronic applications [Data]
No full textResearch Data associated with the related publication. Synthesis and characterization of cinnamate substituted polythiophene (P3ZT). Cross linkage via UV and electron beam radiation; network formation in thin films controlled by infrared spectroscopy and film retention experiments. Patterning via EBL produces nanorods and contact pads/fingers for nanosized transistor employing doped P3ZT as electrodes