Advanced Emergency Medicine (E-Journal)
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Mitochondria-Derived Peptides in Age-Related Diseases: A Review
Get PDFMitochondrial—derived peptides (MDPs) are new kinds of peptides, which are small open reading frames in circular mitochondrial DNA that encode a variety of microproteins, including humanin(HN), SHLPs 1-6, and MOTS-c. It is found that it can regulate mitochondrial bioenergy and mitochondrial metabolism, and has many biological effects such as helping to maintain mitochondrial function and cell viability under stress conditions, giving play to cell protection and improving metabolic markers.In this paper, we review recent research progress in MDPs, examines the biological effects of MDPs and focus on the role of MDPs in ARDs, including mechanism of action and therapeutic potential
A Study on the Correlation Between Sleep Quality and Accidental Injuries Among University Students in Hainan
Get PDFObjective: To analyze the correlation between sleep quality and accidental injuries among university students in Hainan, and to provide reference for improving injury prevention among university students. Methods: A total of 1100 college students from freshman to Senior Students in three universities in Hainan were selected by multilevel random sampling method, and investigated by Pittsburgh Sleep Quality Index (PSQI) and injury questionnaire. Results: The average PSQI score of Hainan university students was 7.645. In the five dimensions of sleep latency, sleep efficiency, sleep disturbances, sleep medication, and daytime dysfunction, as well as the PSQI total score, the differences between the accidental injury group and the non-accidental injury group were statistically significant (P＜0.01), except for sleep quality and sleep time, all other dimensions and PSIQ total score were higher in the accidental injury group than in the non-accidental injury group. Conclusion: The problem of poor sleep quality among university students in Hainan were widespread, and the occurrence of accidental injuries among university students were related to the sleep quality
Design and Study of a Wearable Non-Invasive Photoacoustic Glucose Monitor
Get PDFThis paper relates to a wearable non-invasive photoacoustic blood glucose monitor with a display, control buttons, controller, battery and measurement box in a wearable housing. The wearable case is fitted with a strap that is worn on the wrist of the person being tested. The photoacoustic excitation source and the optical lens system produce a focused laser beam that passes through the hollow multi-ring array sensor and is directed towards the blood vessels in the wrist to achieve continuous A-shaped dynamic focus scanning photoacoustic glucose detection, providing photoacoustic glucose results at multiple sites in the depth direction of the wrist. This paper has the advantages of being compact, portable, easy to operate, enabling real-time monitoring of photoacoustic glucose, non-invasive during testing, eliminating the need to extract blood and provide test strips, and avoiding cross-contamination and environmental effects
Correlation Analysis of Agricultural Injuries and Quality of Life Among Rural Residents in Hainan Province
Get PDFObjective To analyze the correlation between agricultural injuries and quality of life among rural residents in Hainan Province, and to provide a scientific basis for agricultural injury prevention in Hainan. Methods Using a multi-stage random sampling method, one city (county) was randomly selected in each of the five directions of Hainan: east, south, west, north and central. 1-2 towns (townships) were selected in each of the selected cities (counties), then 5-10 natural villages were selected in each town, and 20-30 households were randomly selected in each village (neighbourhood committee) to conduct a face-to-face survey of all permanent residents aged 15 or above in the selected households. Results In both the no agricultural injury group and the group with agricultural injury, there were statistically significant differences (P<0.05) in the six dimensions of Physical Functioning, Role-Physical, Bodily Pain, General Health, Social Functioning and Role-Emotional and in the total score between the two groups, all with the no agricultural injury group scoring higher than the agricultural injury group. The incidence of agricultural injuries showed an overall decreasing trend as the quality of life score increased (P<0.05). Conclusion The incidence of agricultural injuries among rural residents in Hainan is related to the quality of life, and relevant measures should be taken to reduce the incidence of agricultural injuries and improve the quality of life of rural residents in Hainan
The Role of the Pro-Apoptotic Protein Bax in Colon Cancer
Get PDFBax is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the regulation of apoptosis. Bax can be activated by various stimuli and translocate to the mitochondria, where it induces cytochrome c release and caspase activation. Bax expression or activity can be altered in colon cancer cells, resulting in resistance to apoptosis and tumor progression. This article summarized the molecular mech-anisms of Bax activation and function in apoptosis, the alterations of Bax expression or activity in colon cancer cells, and the potential thera-peutic implications of targeting Bax or its regulators in colon cancer
Novel Treatment Strategies for Periodontal Disease: Translational Research from Animal Models to Human Applications
Get PDFObjective: Several emerging periodontal disease treatment strategies were emphasized, aiming to regulate the host immune response through host mediated therapy, which has shown good results in controlling inflammation and promoting periodontal tissue regeneration. Targeted antibacterial therapy, utilizing novel antibacterial drugs targeting periodontal pathogens, has been proven to be effective in reducing bacterial burden and improving clinical parameters. Methods: To conduct in-depth research on the pathogenesis of periodontal disease, discuss the interaction between periodontal health and overall condition, review current treatment methods, and explore promising translational research results, providing new methods for the management of periodontal disease. Results: Animal models play a key role in understanding the complex pathogenesis of periodontal disease and evaluating potential therapeutic interventions. These models allow for investigating disease mechanisms, evaluating treatment efficacy, and exploring safety profiles. By replicating various aspects of periodontal disease in animal models, such as inflammation, alveolar bone loss, and tissue regeneration, valuable insights into disease progression and treatment responses can be obtained. Conclusion: The research on the transformation from animal models to human applications is crucial for developing treatment strategies for periodontal disease. The integration of these emerging methods, including host regulated therapy, targeted antibacterial therapy, tissue engineering, and immunotherapy interventions, has the potential to fundamentally change clinical practice and improve patient prognosis. Further research, including carefully designed clinical trials, is necessary to verify the safety, effectiveness, and long-term effectiveness of these new treatment strategies
Multiple Linear Regression Model of Blood Oxygen Saturation
Get PDFWe used standardized regression analysis to analyze the influence of age and recent smoking status on blood oxygen saturation. We found that blood oxygen saturation was negatively correlated with age and recent smoking status, but whether smoking had a greater influence on blood oxygen saturation than age. In order to further explore whether age and recent smoking status could jointly affect oxygen saturation of blood, we used k-means clustering algorithm and took age as the control variable to conduct clustering analysis. Is obtained by polynomial fitting, and then the blood oxygen saturation under all ages about age, smoking status of recent expression of partial derivatives of recent smoking status, get the following conclusion: smoking is oxygen desaturation, and compared with the young, the elderly smoking more effect on the blood oxygen saturation degree, are more likely to suffer from cardiovascular disease.When the regression results were tested for significance, the significance of all variables was investigated, and it was found that only age and current smoking status were significant for oxygen saturation, while BMI and gender showed no difference from zero in T test, indicating that oxygen saturation was not affected by BMI and gender. Then, taking oxygen saturation as the dependent variable and age and current smoking status as independent variables, the spline interpolation method with the best fitting effect was found, and its expression was given in the text
Validation of Konsung Compass 2000 Dry Biochemical Analyzer
Get PDFDry biochemical analyzers have been increasingly popular in many tests by primary hospitals, field hospitals and other areas subject to economic and medical underdevelopment as well as poor transportation. With the increasing demand for POCT in primary medical care around the world, upgrading of dry biochemical analyzers has been a hot topic in technical research. Against such context, Konsung Compass2000 dry biochemical analyzer, a POCT system with high precision and accuracy, is developed. Furthermore, the upgraded dry biochemical analyzers can, in a more convenient and accurate way, monitor glucose, lipid and other indices affecting the course of chronic diseases
Application of 640-Volume CT in Idiopathic Pulmonary Hemosiderosis in Adults
Get PDFObjective: To have a deep understanding about idiopathic pulmonary hemosiderosis (IPH). Methods: Clinical and imaging data of 6 patients of IPH in adults were collected and analyzed. Results: Imaging findings must be combined with clinical laboratory examination to make a diagnosis of IPH. Transbronchial lung biopsy (TBLB) is the gold standard for evaluation of suspected patients. Conclusion: IPH is extremely rare amid adults, and imaging results on single chest CT are nonspecific. The longitudinal follow-up is critical for diagnosis and posttreatment evaluation
Analysis of the Willingness and Factors Influencing the Residents to Choose Between Chinese Medicine and Western Medicine under the New Coronavirus Pandemic: A Study in Zhejiang Province Community Health Service Center
Get PDFObjective: To understand the willingness of Chinese residents to choose between Chinese and Western medicine in the face of sudden outbreak, this study aims to investigate and analyze the willingness and factors influencing Chinese residents (taking Zhejiang Province as an example) to choose between Chinese and Western medicine under the new coronavirus pandemic. Methods: The present study performed a large-scale cross-sectional online survey among 666 random residents in Zhejiang Province. We used questionnaires to investigate the feedback form from residents seeking medical care. In addition, a multivariate logistic regression model was used to analyze the influence of gender, education, medical reimbursement, and age on the choice of Chinese and Western medicine. Results: Among the patients with mild disease, 55.9% patients chose traditional Chinese medicine, while 44.1% chose Western medicine. Moreover, the proportion of patients with severe diseases who chose traditional Chinese medicine was 7.0%, while the rate of Western medicine was 93.0%. Among the patients suffering from mild diseases, the proportion of men who chose traditional Chinese medicine (46.2%) was lower than that of women (53.8%). The usage of Chinese medicine was preferred among residents of all ages, income levels, and educational backgrounds. A total of 93.0% of patients who chose Western medicine for treatment were severely ill, and the residents with severe diseases preferred Western medicine to Chinese medicine. People with high education and young were more inclined toward Western medicine for treatment compared with Chinese medicine. It was noted that people paid most attention to the medical insurance reimbursement ratio, followed by the distance between the medical institution and the place of residence. Conclusion: The acceptance of Chinese medicine among patients has generally increased; however, gender, educational background, and income still exert a great influence on the choice between Chinese and Western medicine