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TNRL Leadership Lunch Session: Public Consultation with Strategic Planning
No full textA session for the TNRL leadership team to meet with strategic planning consultant J.P. Baker
The Effects of Anxiety on Older Adults
No full textIt is well known that anxiety disrupts cognitive functions such as attention and working memory. Mella et al (2018) found that the detrimental effects of anxiety on cognition are more prominent in older adults with low working memory capacity. Although researchers have found a link between anxiety and cognition, discrepancies regarding what aspects of anxiety (i.e., the worry and/or arousal) affect cognitive functions still exist, particularly, given that direct measures of arousal are largely missing from such findings. This has important implications when obtaining reliable research and clinical interpretations of older adults’ cognitive abilities. The current study looked to analyze the relationship that anxiety components (worry and arousal) have on the cognitive functioning of healthy older adults.
Thirty six participants, twenty young adults (18-25 yrs), and sixteen older adults (over 64 yrs) underwent physiological and psychological testing to assess levels of anxiety during the implementation of cognitive assessments, including the California Verbal Learning Test 3 (CVLT3), the Montreal Cognitive Assessment (MOCA), and the Trail Making Tests (TMT) part A and B. Physiological arousal was measured during the tests using a thermal imaging camera (FLIR E-60) capturing face temperature, a blood pressure monitor (CNAP Monitor 500), and two samples of salivary cortisol. Participants also completed a short version of the Depression Anxiety Stress Scale (DASS) and the State-Trait Anxiety Inventory (STAI-6). Multiple regression analyses were implemented to examine the correlation between measures of anxiety and cognitive function in each assessment and across the age-groups
The Impact of High Intensity Exercise on Carotid Artery Longitudinal Kinetics
No full textLongitudinal kinetics (LOKI) describe the bidirectional movement of the inner lining of arteries. With each cardiac cycle an anterograde movement occurs in early systole, followed by a retrograde movement later in systole and a second anterograde movement in diastole. Prostaglandins are powerful local vasodilators and availability is reduced with ibuprofen (IBU) administration. Our aim was to determine the impact of high intensity cycling exercise and concurrent prostaglandin inhibition on longitudinal displacement. A ramp incremental test on a cycle ergometer was used to determine VO2max, ventilatory threshold (VT) and respiratory compensation (RC) points of participants. An intensity of 33% of the difference between VT and RC was calculated for subsequent trials. On two separate days, participants either ingested IBU or echinacea (control) two hours before testing. Testing began with a 5-minute warm-up immediately followed by 45 minutes of the high-intensity exercise. Three 5-s ultrasound video clips of the carotid artery were obtained immediately before, after and 45 minutes after testing. We used speckle tracking software to analyze longitudinal movement of 4-10 cardiac cycles. A 2-way RM-ANOVA was used to assess differences between conditions at the various time-points. There was no significant difference between conditions, but exercise reduced LOKI immediately and 45 minutes after testing (Pre: 11.8 ± 3.2 Post I: 9.3 ± 1.7, Post 45: 9.4 ± 2.2, p \u3c 0.01). This suggests that complex interactions between sympathetic nervous activity, shear and cardiac dynamics alter longitudinal movements; however, more comprehensive analyses of anterograde and retrograde movements need to be assessed
1B: A Joint Effort: Libraries Working Together to Support Access to Justice
No full textLibraries are positioned to play a critical role in the access to justice crisis that is affecting communities throughout BC. With the closing of governmental services, people are going to their local public libraries for help with ‘every day’ legal problems, such as finding and filling out immigration forms, welfare applications, and court forms, or help in finding information to resolve tenancy or consumer issues.
Libraries have been stepping up to fill this need, but doing so without additional support or resources. This is a systemic problem that will require a coordinated effort. We cannot solve this on our own, but working in partnership, we can have a profound and positive impact in our local communities.
Join us in a conversation where we will discuss the ways Courthouse Libraries BC and LawMatters – CLBC’s unique public library outreach program – are working to engage libraries at the local level to ensure you have the resources you need. We aim to build peer-to-peer relationships that leverage our respective strengths, skills, connections, and resources to enhance local access to legal information services.
You’ll learn about the ways CLBC and LawMatters can help support your day-to-day work, as well as the training and community engagement opportunities we offer. We’d also like to hear from you! Your engagement with the program is critical as your knowledge of local community needs drives our activities. We make it a priority to deliver what we can in response to your feedback, so please join us and share your experiences
3C: Hatching a Library Program: Chick hatching at the Merritt Library
No full textIn spring 2019, the Merritt Library hosted our first chick hatching program and we would love to share our successful experience. This session will be designed to help other branches determine if this could be a good fit for their community and learn from our first experience.
Ros Duclos and Meg Gregory will be presenting on the chick hatching program including how it started, why it worked, what we learned, and where we’re going from here. Ros will start by explaining the nature of chickens and chick hatching as well as how the conversation started. From there, Meg will discuss the details and preparation needed to ensure the program’s success in a library setting. We\u27ll discuss various aspects of the program such as preparing social media posts and connecting this program to existing ones. We learned a lot and there were some surprises. For example, patrons were so excited to meet and cuddle the chicks that we found it necessary to enforce afternoon naptime for the fluffy youngsters. From the success of this program, we are now planning a library Giving Garden that will share the same focus on understanding and engaging with nature, something we know is being lost in communities of all sizes.
Chick hatching worked in Merritt because it was a great match to our community members. We would love to share our experience and lead an activity to encourage others to find something unique for their community
2A: They are us: Engaging with 3 marginalized patron bases in the Downtown Kelowna Library
No full textThe Downtown Kelowna Branch of the Okanagan Regional Library is located between million-dollar condos and shelters for people experiencing homelessness. The library is at the center of the Cultural District and has a diverse community. Our service model has evolved to represent the large variety of users such as, families, tech entrepreneurs, health services employees, local businesses, students and a street population that regularly frequent the library. Our goal is to represent and engage with everyone in our service area. We have focused on connecting with the marginalized segments of our population by bringing them to the forefront of service and programming. This talk will focus on three initiatives undertaken by the staff of the Kelowna Branch. An empathy-based approach to serving our patrons who are experiencing homelessness A Book Club designed for but not limited to patrons with diverse abilities A Drag Story Time which sparked controversy and conversation with the community
The question, “Why do you let them in the library?” still gets asked.
The answer is simple, “they are us.
Characterization of the Antimicrobial Secondary Metabolites Produced by the Cave Bacteria Streptomyces ICC1
No full textThe progression of antibiotic resistant microorganisms has hindered some of the commercially available pharmaceutical drugs ineffective. Therefore, there is an overwhelming need for new alternatives against multi-drug resistant microbes, or mankind is likely to be surpassed in the current coevolution race between ourselves and bacteria. This study examines the secondary metabolites produced by cave-dwelling Streptomyces sp. ICC1 strain, which is prevalent in the isolated environment of the Iron Curtain Cave in Chilliwack, British Columbia. The secondary metabolites secreted by Streptomyces sp. ICC1 strain have shown antimicrobial properties that are effective against both laboratory and multi-drug resistant strains of Escherichia coli and Staphylococcus aureus. In extreme-conditions, such as a cave, microbial species often exhibit bioactivity that arises from resilient physiology and specialized metabolic pathways.
Streptomyces sp. ICC1 strain will be grown in a temperature of 15°C in both nutrient agar and broth. This strain has been exposed to many different media types and seems to favour a simple nutrient broth, here the cave dwellers produced the characteristic brown pigment in 72 hours. Bioassays will be performed to confirm antimicrobial activity in both laboratory and drug-resistant strains of Escherichia coli and Staphylococcus aureus. Upon presence of bioactivity, extractions will be performed to isolate the active compound(s), which will then be purified via high performance liquid chromatography. The secondary metabolites have been reasoned to exhibit both polar and non-polar substituents. Therefore, further instrumental analysis performed on pure samples must be done to reveal the true molecular nature of the bioactive metabolites, as well as their mode of action
Investigating the Interaction Between Bisphenol-S and Human Serum Albumin Using Affinity Capillary Electrophoresis
No full textBisphenol S (BPS) has been identified as a suitable subsitute to bisphenol A (BPA) due to its high stability and other features. Recent studies have shown that BPS might have a similar effect as BPA by acting as a potential endocrine-disrupting chemical with a harmful effect on human and animal health. Exposure to BPS has a negative effect on the reproductive, endocrine and cardiovascular system. Human serum albumin (HSA) is the most abundant protein in the human blood plasma and is involved in the transport of various fatty acids, hormones and other molecules around the body. Due to its function and abundance, it is the Ideal protein for the study of the health implications of the new substitute (BPS).
This study aims to determine the interaction between BPS and HSA using affinity capillary electrophoresis (ACE) and nuclear magnetic resonance (NMR) spectroscopy. From the changes in migration time at different concentrations of the additive (HSA), ACE will yield a binding constant that represents the strength of the interaction. A similar study is done using NMR spectroscopy. A change in the chemical shift upon the addition of increasing concentration of BPS is modelled to calculate the binding constant and give an indication of the strength of interaction. The result of this interaction study will provide more information on the health effects of BPS
Study of the Binding Interaction between β-Cyclodextrin and Carbendazim using Nuclear Magnetic Resonance Chemical Shift Titrations
Get PDFFollowing a recent study of the interaction between β-Cyclodextrin and thiabendazole,1 the present study focuses on the interaction between the same macrocyclic polymer and another guest molecule, carbendazim. To this effect, solubility tests using water, acetone, chloroform, acetonitrile, methanol and dimethyl sulfoxide deuterated were performed in order to determine the best NMR solvent for the analysis. We found that DMSO-d6 was appropriate.
In order to quantify the strength of the interaction between the two chosen molecules, stock solutions of both host and guest molecule were prepared, and 1H-NMR chemical shift titrations have been carried out. From the data obtained, we are determining the binding constant (Ka) applying the Rose-Drago Method. Calculated binding constants using NMR spectroscopy will be compared to those obtained by other analytical methods.
1 Albert Guillem Adserias Rodriguez; Nuclear Magnetic Resonance Spectroscopy Study of the Binding Interaction between β-Cyclodextrin and Thiabendazole: A Supramolecular Inclusion Complex