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Akciğere Yönelik Stereotaktik Beden Radyoterapisi İçin Bilgi Tabanlı Planlama Kapsamında Klinik Bir Modelin Değerlendirilmesi
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The impact of the Naples prognostic score on outcomes in patients undergoing coronary artery bypass grafting
No full textBackgroundThis study aimed to evaluate the prognostic value of the Naples prognostic score (NPS) in patients undergoing isolated coronary artery bypass grafting (CABG).MethodsPatients undergoing isolated CABG were retrospectively analyzed. Patients were stratified into three groups based on preoperative NPS values. Thirty-day and one-year mortality, postoperative atrial fibrillation (AF), intensive care unit (ICU) and ward length of stay were recorded. Logistic regression analysis was used to assess the independent predictive value of NPS. Its contribution to the European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) model was evaluated using ROC curves and Nagelkerke R².ResultsA total of 1.195 patients were included. Higher NPS was significantly associated with 30-day (odds ratio [OR] =1.838) and 1-year mortality (OR=1.620) (p<0.001). Postoperative AF was significantly more common in higher NPS groups (p=0.010). NPS was significantly associated with both ICU length of stay (p<0.001) and ward length of stay (p=0.029). The addition of NPS to EuroSCORE improved the predictive performance for both 30-day and 1-year mortality. Patients with higher NPS had significantly lower survival during follow-up.ConclusionThe NPS is an independent and significant predictor of short- and long-term mortality in patients undergoing isolated CABG. As a simple, objective score reflecting both inflammatory and nutritional status, NPS enhances the predictive capacity of established risk models when integrated preoperatively.</p
Process safety assessment of PV valve failures on chemical tankers using a hybrid HAZOP–Bayesian Network approach
No full textThe marine transport of hazardous chemicals presents significant risks, particularly when containment systems like Pressure Vacuum (PV) valves fail. Malfunctioning PV valves can cause overpressure or vacuum conditions, leading to cargo tank rupture or implosion. This study introduces a hybrid methodology combining Hazard and Operability (HAZOP) analysis with Bayesian Network (BN) modeling to evaluate the probability and environmental consequences of PV valve failure on chemical tankers. Expert-led HAZOP sessions identified critical deviations, root causes, and potential safeguards. These insights were integrated into a fuzzy Bayesian framework to quantify spill likelihoods. The integration of fuzzy logic with Bayesian Networks allows expert linguistic judgments to be mathematically captured, reducing epistemic uncertainty where historical data are scarce. Results indicate a 19.4 % probability of tank rupture due to PV valve failure, with valve freezing and poor maintenance as major risk factors. Sensitivity analysis reveals that human factors, particularly operator distractions, substantially increase spill risk. The hybrid approach enables early risk detection and supports proactive prevention strategies. This framework serves as a decision-support tool for maritime safety authorities, operators, and policymakers to enhance environmental protection in hazardous chemical shipping
UA-DMSPEDeterminationofCu(II),Cd(II),andAs(III) inWater,Soil, andTomatoUsingaNovelThiosemicarbazoneSorbent: ICP-OES PerformancewithDFTCharacterizationandAntimicrobial-Target Docking
No full textHeavymetalpollutionremainsacriticalglobal issue due tothe toxicandbioaccumulativenatureof elements, suchas Cu(II),Cd(II), andAs(III).Theiroccurrence inwater, soil, and foodproducts�particularly vegetables�poses serious ecological andhealthrisks. Inthiswork, anovel thiosemicarbazone(TSC) derivativewassynthesizedandstructurallycharacterized,whichhas not been previously reported in the literature. The ligandwas covalently immobilizedontoasilica-basedsorbent andappliedin anultrasound-assisteddispersivemicrosolidphaseextraction(UADMSPE)protocol fortheselectiveextractionandpreconcentration ofCu(II),Cd(II), andAs(III).Themethodwasvalidatedonreal samples, including irrigationwater, agricultural soil, and tomato matricescollectedfromtheGedizRiverBasin(Türkiye), aregion of intensiveagricultural activity.CoupledwithICP-OES, thedevelopedprocedureprovidedhighsensitivity, lowdetectionlimits, andreliableperformancewithminimalmatrixeffects. Inaddition,densityfunctional theory(DFT)calculationswereperformedto probe the electronic features and reactivityof the ligand, whilemolecular docking studies explored its potential antimicrobial interactions.This integratedapproachhighlightsthemultifunctionalityof theTSCligand,offeringbothenvironmentalmonitoring capabilities and prospective biomedical applications. Overall, the proposed method demonstrates analytical robustness, environmental compatibility, andastrongpotential for routinetracemetal surveillance incomplexmatrices.</p
Therapeutic potential of human Wharton's Jelly-derived mesenchymal stem cells (hWJ-MSCs) for treating clinical and subclinical mastitis in dairy cows
No full textThis pioneering study explored the therapeutic potential of human Wharton's jelly derived mesenchymal stem cells (hWJ-MSCs) as a novel regenerative treatment for subclinical (SCM) and clinical mastitis (CM) in dairy cows, a condition that poses significant economic and health challenges. hWJ-MSCs were isolated and characterized, and then administered intramammarily in two doses, seven days apart, to twelve cows that were divided into control, SCM, and CM groups. Comprehensive evaluations, including somatic cell count (SCC), proinflammatory cytokine profiles, milk yield, and bacteriological analyses, were conducted before treatment and on days 14 and 21 after treatment. The results revealed a remarkable reduction in SCC by 29.62 % in the SCM group and 70.46 % in the CM group, accompanied by a pronounced suppression of proinflammatory cytokines such as TNF-alpha and IL-1 beta. hWJ-MSCs therapy also led to substantial improvements in milk yield, with increases of 39.38 % and 14.32 % in the SCM and CM groups, respectively. Moreover, bacteriological analyses revealed the complete eradication of pathogenic agents, including Staphylococcus aureus and Escherichia coli, in nearly all treated patients. These findings underscore the potential of hWJ-MSCs to redefine mastitis management by offering a safe, effective, and antibiotic-free alternative, addressing both agricultural and global health concerns related to antimicrobial resistance. The significant therapeutic effects observed in this study suggest that hWJ-MSCs could be used to treat mastitis, paving the way for advanced stem cell-based interventions in veterinary medicine. Further large-scale studies are warranted to validate these promising results and establish hWJ-MSCs as a cornerstone of sustainable livestock health management
Emission based sensing of N-acetyl cysteine via silver equipped anthraquinone derivatives
No full textIn this work we investigated emission-based response of silver complexes of two newly synthesized anthraquinone derivatives for N-acetylcysteine (NAC) and thioglycolic acid. The interaction of the probes, DHA-dibenzonitrile and DHA-dibutanenitrile with silver nanoparticles resulted in metal chelation and following quenching of the fluorescence. To determine whether the emission intensity of the complexes was re-stored again, thiol compounds; NAC and thioglycolic acid were used. The released dyes re-emitted light, allowing the system to exhibit an intensity-based turn-on type sensor behavior for the NAC and thioglycolic acid, respectively. The re-stored fluorescence was monitored as a strong emission based analytical signal at 560 nm. The complex stoichiometries were investigated using several approaches, including Job's plot, density functional theory (DFT) and FT-IR measurements. The findings relying on HOMO-LUMO and energy gap calculations highlight that Ag coordination and following acetylcysteine adduction significantly re-shape both local nucleophilic and electrophilic regions, modulating the global electronic structure and reactivity of anthraquinone derivatives. N-acetylcysteine exhibited an exceptional spectral response at pH 9.0 in a buffered solution exhibiting 13.6 and 14.4-fold enhancement in the emission intensity, respectively. The reported linear responses for a concentration range of; 1.0 × 10−5 M -1.0 × 10−2 M, can easily be adopted to determination of the NAC levels in drugs, in vitro studies or in serum samples. Limit of detection (LOD) and limit of quantification (LOQ) values of the DHA-dibutanenitrile derivative for the NAC molecule were found to be 1.28 × 10−6 and 1.21 × 10−5 mol × L−1, respectively. Similarly, the DHA-dibenzonitrile exhibited 1.11 × 10−6 and 1.28 × 10−5 mol × L−1 of LOD and LOQ values, respectively.</p