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The Investigation of the Antiviral Effect of Cistus Laurifolius Plant Extract, Rich in Phenolic Compounds, Against Seasonal Influenza A Viruses
No full textCurrent Status of Cystic Fibrosis in Türkiye: Data from the National Registry
No full textOBJECTIVE: The Cystic Fibrosis Registry of Türkiye (CFRT) was established by the Turkish Pediatric Respiratory Diseases and Cystic Fibrosis Society and has provided detailed information on demographic, clinical, genetic, and treatment-related aspects of cystic fibrosis (CF) patients since 2017. We aimed to describe the current status of CF in Türkiye using CFRT’s 2023 annual data. MATERIAL AND METHODS: Demographic, clinical, and treatment data were taken from CFRT’s 2023 record. RESULTS: In 2023, 2,258 patients from 34 centers were recorded. The median age of patients was 9.1 years, and 46.9% were female, with a median age at diagnosis of 0.3 years. Only 14.9% of the patients were older than 18 years. Genetic analyses were completed in 97.3% of patients. The most common variant, F508del, had a total variant frequency of 22.1%. The median percent predicted FEV1 and FVC were 88.0 and 94.0 in those aged 6-17 years 71.0 and 84.0 in those aged ≥18 years, respectively. The median values of body mass index z-scores were-0.5, and-0.5 for patients 2-18 and older than 18 years, respectively. Chronic colonization with Pseudomonas aeruginosa was present in 17.2% of the patients. Most patients used inhaled recombinant human DNase (87.1%) and oral pancreatic enzyme replacement treatment (83.0%). CF transmembrane conductance regulator (CFTR) modulators were used by 15.9% of patients. Over the year, 24 patients died, with a median age at death of 13.3 years. CONCLUSION: The CFRT report provides a valuable resource showing the clinical and laboratory data of patients with CF in the country
A novel adaptive façade using cable-driven compliant mechanisms
No full textAdaptive fa & ccedil;ade systems have the potential to significantly reduce energy consumption and CO2 emissions while enhancing, among others, the thermal and lighting comfort of building occupants. However, most existing adaptive fa & ccedil;ades rely on rigid body mechanisms, which introduce mechanical complexity and increase maintenance costs. To address these challenges, bio-inspired compliant mechanisms, which use flexible elements capable of elastic deformation, offer a promising solution by eliminating the need for conventional hinges. However, studies in the literature show that while such systems often succeed in reducing the number of hinges, they do not typically achieve a reduction in the number of actuators. This study addresses the gap by combining cable networks with compliant mechanisms to minimize the number of actuators while proposing a holistic approach that integrates kinematic design, material selection, pattern development, structural analysis, and daylight performance evaluation. The study uses computer simulations to evaluate the system's kinematic characteristics, material properties, structural integrity, and daylight performance. The study explores fa & ccedil;ade patterns, cable networks, and actuation systems, alongside structural and environmental analyses, to develop an efficient and innovative adaptive fa & ccedil;ade system that simplifies mechanical design and enhances visual comfort
Paleoseismological analysis of the Palu Segment within the East Anatolian fault system: Implications for seismic hazard assessment
No full textThe Palu segment, situated in the northeastern part of the East Anatolian Fault System (EAFS), is a crucial structural feature with notable seismic potential. This study examines the paleoseismic activity of the Palu segment through trench excavations and geochronological analyses utilizing Optically Stimulated Luminescence (OSL) and radiocarbon (14C) dating methods. Two trenches, located near Karşıbahçeler, exposed evidence of multiple surface-rupturing seismic events spanning the Holocene and Pleistocene epochs. Chronological analyses identified five distinct seismic events in trench 1 (P1), dated between 94.09 ± 6.07 ka and 0.84 ± 0.45 ka, and three events in trench 2 (P2), dated between 28.83 ± 1.61 ka and 351 ± 21 BP. Bayesian analysis using Oxcal distribution suggested event timings between 90.52 ± 25.99 ka and 1.25 ± 0.55 ka. Comparative analysis with historical earthquake records correlates the most recent event with the 1789 or 1874 AD earthquakes, while the penultimate event matches the 995 AD earthquake. Earlier events reflect prehistoric tectonic activity. The recurrence intervals for these events range from 710 to 5,370 years during the Holocene, with evidence of seismic activity extending into the Pleistocene. Stress inversion analyses and geodetic data indicate a predominantly strike-slip stress regime, consistent with geometry of the fault. These findings provide critical insights into the long-term seismic behavior and recurrence patterns of the Palu segment, enhancing seismic hazard assessments for the region
Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Türkiye
No full textThis multicenter retrospective study analyzed 336 patients (236 adults, 100 children) who underwent liver transplantation (LT) for acute liver failure (ALF) between 2002 and 2019 across 14 centers in Türkiye. The aim was to evaluate pretransplant factors influencing short-term posttransplant survival. Median MELD and PELD scores were 31 and 30, respectively. The most common ALF etiologies were viral, indeterminate, and drug-induced causes. Living donor liver transplantation (LDLT) was more common in children (86.0%) than adults (57.2%). Mean posttransplant survival was 166±9 months in children and 117±6 months in adults. In adults, LDLT significantly improved survival compared to deceased donor LT (DDLT), with survival of 135 vs. 89 months (p=0.0012). Although pediatric LDLT recipients had longer mean survival than DDLT recipients (167 vs. 132 months), this difference was not statistically significant (p=0.5959). Three-month mortality was associated with low albumin and grade 4 hepatic encephalopathy (HE) in children. In adults, independent predictors of early mortality included DDLT, serum sodium >140 mEq/L, MELD >35, pH <7.3, and grade 4 HE. Our data suggest that LDLT may offer a survival advantage, particularly in adults with ALF. Identifying pretransplant risk factors is essential for improving early outcomes and guiding clinical decision-making
Impact of COVID-19 on Primary Healthcare Research: Trends and Suggestions for Better Services Approaches Via Blockchain Based Applications
No full textImpact of COVID-19 on Primary Health Care Research Trends and Suggestions for Better Services Approaches Via Blockchain Based ApplicationsImpact of COVID-19 on PHC & Blockchain Based ApplicationsAbstractObjective: The authors assessed how research in primary healthcare was affected by the COVID-19 pandemic and identified the potential of blockchain technology to address pandemic-related challenges.Methods: This quantitative bibliometric research study used machine learning techniques. A comprehensive analysis of all primary healthcare (PHC) research was conducted using bibliometric data from the WOs. We examined co-authorship, co-occurrences, citation and co-citation, thematic mapping, factorial, document, and Latent Dirichlet Allocation topic analyses. Our main dataset was 1,885 articles produced by 9,185 researchers from 3,132 institutions in 113 countries.Results: The most cited studies in the PHC field during the pandemic related to telemedicine and remote consultation, along with clinical conditions such as mental health, diabetes, vaccinations, risks during pregnancy, and healthcare of the elderly. In addition, the impact of COVID-19 on educational outcomes, changes to the organization of care, experiences and challenges to PHC physicians and other health professionals, and the diversity of COVID-19 symptoms were prominent.Conclusions: The PHC researchers adapted quickly to the pandemic and conducted multidisciplinary research that helped to mitigate the impact on individuals, health systems, and society. Within this context, blockchain technology can be used to facilitate the security of health data, resource management (e.g., monitoring of the vaccine supply chain), and global collaboration toward pandemic control. By providing transparency, security, and efficiency in these areas, blockchain technology might lead to more effective pandemic preparedness and management in the future.erisim icin: https://doi.org/10.30953/bhty.v8.400</p
