Universidad Internacional del Ecuador
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Viral Zoonozlar ve Vektör İlişkili Epidemik Virüsler
No full textEnfeksiyonların küresel dağılımındave kitlesel yayılımında en etkili aracılar gıdalardır. Gıda kaynaklıenfeksiyonlar, enfekte bir hayvandan sağlanan bir ürün olabileceği gibi gıdanınüretim ve işleme ortamında ya da uygun şekilde denetlenmeyen koşullarda üretimindende kaynaklanabilir. Gelişmişlik düzeyi ayırdetmeksizin küresel bir sorun olan gıdakaynaklı enfeksiyonlarda rol oynayan viral etkenlerin çoğu zoonoz karakterdedirve bu etkenlerden norovirus, hepatitis E virusu, rotavirus ve astroviruslar hastalıksalgınlarında yaygın olarak görülmektedir. Bu zoonotik virusların gıda zincirinegirişinin önlenmesi Avrupa Yeşil Mutabakatı kapsamında hazırlanan “ÇiftliktenÇatala Stratejisi” ve “Tek Sağlık Konsepti” dikkate alınarak değerlendirilmelidir.Bu amaçla, sürdürülebilir gıda sisteminin oluşturulması, sürdürülebilir gıdazincirinin inşa edilmesi ve küresel çapta gerekli önlemlerin alınması ve sıkıhijyen önlemlerinin uygulanması son derece önemlidir. Bu bölüm, gıda kaynaklıviral zoonozlarının tamamını içermese de insan sağlığını birincil derecedetehdit eden ve ülkemizde varlığı yaygın olarak bildirilen etkenler ön planaalınarak hazırlanmıştır. </p
Prevalence, risk level and risk factors of diabetic foot ulcer among adult individuals with diabetes in the Southeastern Anatolia Region of Turkiye
No full textObjective: The aim of the study was to determine the prevalence, risk, and predisposing factors of diabetic foot ulcers in adults with diabetes. Methods: This study is multi-centered descriptive cross-sectional research. Data were collected between June 2022 and November 2022 in seven cities, including five teaching and research hospitals and two public hospitals. The study included 357 people with diabetes. The sample was selected using stratified and systematic sampling. General demographic characteristics, medical history, laboratory and foot examination results, history of foot ulcer and/or amputation, skin and nail problems, peripheral sensory loss (10 g-Semmes-Weinstein monofilament) and vascular assessment were obtained. Logistic regression analysis was used to screen for factors affecting the diabetic foot. Results: The prevalence of diabetic foot ulcers was 17.1 % (%13.2-%21.5; %95 CI). Among 296 individuals with diabetes without foot ulcers, 86.5 % (256) had risk level 0, 7.3 % (26) had risk level 1, 3.4 % (10) had risk level 2, and 1.4 % (4) had risk level 3. In regression analysis, the variables of peripheral arterial disease (Exp β: 3.781 - P = .027), history of ulcer (Exp β = 26,180 - P < .001), edema (Exp β: 9.784 - P < .001), fungus between the toes (Exp β = 5.284 - p = .009) were associated with a significantly increased risk of developing diabetic foot. Conclusion: The prevalence of diabetic foot ulcers was found to be approximately two out of every 10 patients with diabetes, and peripheral arterial disease, history of ulcers, edema, and presence of fungus between the toes were found to be among the risks predicting diabetic foot. All diabetic individuals should be diagnosed in terms of diabetic foot risk factors, and follow-up and treatment should be planned considering the basic building blocks of diabetic foot prevention according to the determined risk group
EXPLORING THE ASSOCIATION BETWEEN AUTOANTIBODY PROFILES AND THE DEVELOPMENT OF DIGITAL ULCERS IN SYSTEMIC SCLEROSIS PATIENTS: A COMPREHENSIVE ANALYSIS
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Halal Tourism and Social Media Marketing: The Moderating Effect of Religious Social Control in the Context of Stimulus Organism Response and Source-Credibility Theory
No full text.the aim of this study is to examine the effect of social media marketing activities on onlineimpulse buying in halal tourism within the context of the stimulus-organism-response (s-O-R)and source-credibility theories (sct). additionally, the moderating effect of religious socialcontrol on the relationship between social media marketing activities and the perception ofthe source as attractive, trustworthy, and expert is being tested. these relationships wereanalyzed within the framework of structural equation modeling. amos and the sPss hayesMacro extension were utilized. a total of 512 valid surveys were collected from turkishconsumers who declared that they were Muslim and had a holiday within the scope of halal<span class="markedContent" id="p3301R_mc18" style="font-size: 16px; box-sizing: content-box; padding: 0px; margin: 0px; position: absolute; transform-origin: 0px 0px; color: rgba(0, 0, 0, 0); white-space: pre; cursor: text; top: 0px; height: 0px; font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", "Liberation Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji
Influence of Mucoadhesive Polymers on Physicochemical Features and Biocompatibility of Collagen Wafers
No full textThe aim of this study was to develop and characterize some freeze-dried wafers based on collagen and two mucoadhesive polymers, namely, hydroxypropyl methylcellulose (HPMC) and Carbomer 940 (CBM). The wafers were obtained by lyophilization of the corresponding hydrogels, which were evaluated by circular dichroism in order to investigate mucoadhesive polymers’ influence on collagen’s secondary structure. The obtained freeze-dried wafers were characterized by FT-IR spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), contact angle measurements, and water uptake capacity. Furthermore, biocompatibility assessment was performed by evaluating the impact of freeze-dried wafer extracts on cell viability, morphology, and migration capacity. Circular dichroism showed more significant changes in the secondary structure of collagen associated with the addition of Carbomer 940. The FT-IR spectra displayed specific peaks for collagen and the two mucoadhesive polymers. SEM images illustrated a microporous structure for both collagen and Carbomer 940, while HPMC displayed a more sheet-like structure. The addition of HPMC increased the thermal stability of collagen, while Carbomer 940 had a negative impact on the samples’ thermal stability. Contact angle measurements and water uptake capacity showed good hydrophilicity of the wafers. Except for CBM 100%, all samples supported the viability of human fibroblasts and did not have any inhibitory effect on cell migration capacity, demonstrating good biocompatibility, which is an essential attribute in developing drug delivery supports intended for mucosal applications
Evaluation of serum CA15-3, CEA, Ki-67, PDL-1 and VEGF as a potential diagnostic and prognostic biomarkers in canine mammary tumors
No full textCanine mammary tumors are the most common tumor type among all cancer types. The study aims to evaluate the presence of tumor and early metastasis by comparing CEA, CA15-3, Ki-67, VEGF, and PD-L1 profiles in canine mammary tumors with and without metastasis and in healthy dogs, and to understand the effectiveness of the parameters in tumor diagnosis and prognosis. Female dogs with mammary tumors were divided into two groups as metastatic (n = 20) and non-metastatic (n = 20) according to anamnesis, physical examination, blood analysis, imaging methods, and histopathology. Dogs without active complaints and applied to the clinic with a request for routine neutering constituted the healthy group (n = 20). Serum samples were taken from dogs in all groups, and serum CA15-3, CEA, VEGF, Ki67, and PD-L1 levels were measured with ELISA. The levels of CEA and CA15-3 were significantly higher in the serum of dogs with mammary tumors (metastatic and non-metastatic) compared to healthy ones. Serum VEGF levels were found to be highest in dogs with metastatic mammary tumors. Dogs with non-metastatic mammary tumors were found to exhibit the highest serum levels of Ki-67. There were no significant differences in PD-L1 among groups. A strong positive correlation was detected between all serum parameters. CEA, CA15-3, VEGF, and Ki-67 could be a useful diagnostic tool for canine mammary tumors with the AUC values of 0.770, 0.693, 0.696, and 0.902, respectively. In addition, Ki-67 was the best predictor of metastasis in dogs with mammary tumors, with an AUC value of 0.902. In conclusion, serum CEA, CA15-3, VEGF, and Ki-67 parameters can be applied to increase the efficiency of diagnosis and prognosis evaluation in canine mammary tumors