Journal of Ayurveda and Integrated Medical Sciences (JAIMS)
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Ayurvedic Interventions in Preventing Selenite-Induced Cataract: A Comprehensive Review
No full textBackground: Cataract remains one of the primary causes of vision loss globally and is anticipated to increasingly strain healthcare services in the coming years. At present, the restoration of vision in cataract patients is predominantly achieved through surgical removal of the opacified lens followed by intraocular lens implantation. However, for individuals where surgery is not a viable option, effective pharmacological treatments are lacking. In such instances, the concept of preventive ophthalmology offers an alternative pathway aimed at delaying or preventing cataract onset. Ayurveda describes numerous herbal formulations that detoxify and rejuvenate body systems, potentially slowing down age-associated changes including lenticular opacity. Numerous experimental investigations using various cataract models have evaluated the prophylactic potential of Ayurvedic drugs. This review compiles recent scientific data focused on sodium selenite-induced cataractogenesis, a widely accepted experimental model due to its similarity with human senile cataracts.
Objective: To assess the protective effects of selected Ayurvedic formulations against sodium selenite-induced cataract development.
Materials and Methods: Clinical trials and experimental data from databases such as Google Scholar, PubMed Central, and NCBI were reviewed to gather evidence on Ayurvedic interventions in selenite-induced cataract models.
Results: Thirteen studies met the inclusion criteria. Collectively, they demonstrated that Ayurvedic formulations helped delay cataract formation by restoring antioxidant enzyme activity, reducing lipid and protein peroxidation, maintaining redox balance, and preserving lens ionic homeostasis.
Conclusion: The reviewed literature supports the potential efficacy of Ayurvedic drugs in the prevention of cataractogenesis, especially through their antioxidative mechanisms
Conceptual Study on Mamsavaha Srotas - A Scientific Evaluation
No full textAyurveda describes Srotas as fundamental channels that regulate transport, transformation, and sustenance of life. Among them, Māṁsavaha Srotas are vital for the nourishment and maintenance of Māṁsa Dhātu (muscle tissue). The classical Ayurvedic texts provide descriptions regarding the origin (Mūla), function, and pathological conditions of these channels and system. Ayurveda describe different types of systems according to different parts or mechanism of body. This conceptual review aims to evaluate Māṁsavaha Srotas in the light of modern perspective, correlating them with the musculoskeletal and vascular systems. It highlights their physiological role, pathological manifestations, and clinical significance, thereby providing a scientific foundation for integrative understanding
Chronic Diabetic Foot Ulcer using Leech Therapy and Ayurvedic Formulations: A Case Report
No full textBackground: Chronic diabetic foot ulcer is a challenging complication of diabetes mellitus, often resistant to conventional therapy. Ayurveda describes such non-healing ulcers as Dushta Vrana, emphasizing Shodhana (purification) and Ropana (healing) interventions, including Jalaukavacharana (leech therapy).
Methods: A 65-year-old male with a 2–3-year history of a non-healing plantar ulcer, unresponsive to allopathic care, was treated using an integrative Ayurvedic protocol. Interventions included leech therapy every 15 days for 3 months, then monthly for 3 months; local application of Jatyadi Taila combined with Kasisadi Bhasma; internal administration of Amrita Guggulu, Kaishora Guggulu, and Triphala Guggulu; and regular debridement and cleansing. Wound healing progress, sensation, and granulation were monitored over 12 months.
Results: Partial sensory return and healthy granulation tissue appeared within 2–3 months. By 6 months, the ulcer showed significant reduction in size, decreased discharge, and epithelialization. Complete wound closure with stable scar formation was observed at 12 months. The patient’s general health and vitality also improved.
Conclusion: Integrative Ayurvedic management combining leech therapy, local medicated applications, and systemic herbal formulations successfully healed a chronic DFU where conventional therapy failed. This case demonstrates the potential of Ayurveda as a safe and effective alternative or complementary approach for chronic non-healing wounds. further clinical trials are recommended
Ayurvedic management of Irritable Bowel Syndrome and Dyspepsia: Clinical Insights - An Integrative Review
No full textBackground: Irritable Bowel Syndrome (IBS) and functional dyspepsia are among the most prevalent functional gastrointestinal disorders, characterized by abdominal pain, altered bowel habits, bloating, indigestion, and impaired quality of life. Their multifactorial origin involves gut–brain axis dysfunction, altered motility, dysbiosis, and psychological stress. Despite available pharmacological options, long-term management remains challenging due to high relapse rates and limited efficacy. Ayurveda, with its holistic approach, provides an alternative framework that emphasizes the correction of Agni (digestive fire), elimination of Ama (metabolic toxins), restoration of Dosha balance, and psychosomatic harmony.
Aim: This review aims to explore Ayurvedic concepts, therapeutic approaches, and clinical insights in the management of IBS and dyspepsia, and to correlate them with modern biomedical perspectives.
Materials and Methods: A comprehensive review of classical Ayurvedic texts (Charaka Samhita, Ashtanga Hridaya, Bhavaprakasha) was conducted along with an electronic database search (PubMed, AYUSH Research Portal, Google Scholar, ScienceDirect, Cochrane Library). Clinical studies, observational trials, and review articles published between 2000–2025 were included. Ayurvedic formulations, Panchakarma interventions, dietary practices, and lifestyle recommendations were critically analyzed and compared with modern medical approaches.
Results: Ayurvedic literature identifies Grahani Roga and Ajirna as classical correlates of IBS and dyspepsia, with pathogenesis rooted in Agni Mandya and Ama formation. Management strategies include Shodhana (detoxification through Virechana and Basti), Shamana (Deepana-Pachana, Grahani-Nashaka formulations such as Kutajarishta, Hingvastaka Churna, Avipattikara Churna), dietary modifications (Takra Kalpana, Mudga Yusha, old rice), and Satvavajaya Chikitsa (Yoga, meditation, Pranayama). Clinical trials have demonstrated improvements in bowel regularity, bloating, and abdominal pain with Ayurvedic therapies, showing comparable or superior outcomes to conventional treatments in long-term relief.
Conclusion: IBS and dyspepsia require a holistic, patient-centered approach. Ayurveda offers a comprehensive management plan that addresses not only digestive symptoms but also underlying metabolic and psychosomatic factors. Clinical evidence supports the efficacy of Ayurvedic interventions, though large-scale randomized controlled trials are warranted for wider acceptance. Integration of Ayurvedic principles with modern medicine may provide an effective, sustainable, and personalized strategy for the management of functional gastrointestinal disorders
Clinical Evaluation of Standardized Ashwagandha Tablet in Stress, Anxiety, and Cognitive Function: A 60 Day Open Label Study
No full textBackground: Stress and anxiety are highly prevalent worldwide, contributing to impaired quality of life and increased risk of chronic disease. Conventional pharmacotherapies are limited by side effects and accessibility, prompting interest in natural adaptogens such as Withania somnifera (Ashwagandha). This study evaluated the effects of standardized Ashwagandha root extract (tablet) on stress, anxiety, quality of life, and cognition in adults with mild to moderate symptoms.
Methods: An open‑label, single‑arm, pre–post clinical study was conducted over 60 days at an Ayurvedic clinic in Pune, India. Sixty participants aged 18–60 years with PSS ≥14 and GAD‑7 scores 5–14 were enrolled; 54 completed the study. Participants received ARE‑500 mg tablets (two tablets twice daily; 2,000 mg/day). Primary outcome was change in Perceived Stress Scale (PSS). Secondary outcomes included GAD‑7, WHOQOL‑BREF domains, and safety assessments. Statistical analyses used paired t‑tests/Wilcoxon signed‑rank tests with 95% confidence intervals.
Results: Ashwagandha supplementation produced significant improvements across all endpoints. PSS scores decreased by 70% (24.1 ± 5.2 to 7.2 ± 3.1; p < 0.001). GAD‑7 scores reduced by 70% (11.0 ± 2.8 to 3.3 ± 1.9; p < 0.001). WHOQOL‑BREF domains improved by ~70% in physical, psychological, social, and environmental measures (all p < 0.001). No serious adverse events were reported; minor gastrointestinal discomfort resolved spontaneously.
Conclusion: Standardized Ashwagandha root extract was safe, well tolerated, and associated with robust improvements in stress, anxiety, quality of life, and cognition. These findings support Ashwagandha’s adaptogenic role and highlight its potential as a culturally relevant, evidence‑based intervention for stress management in community settings
A Clinical Study to Evaluate the Efficacy of Yavadi Ghritam (locally) along with Haritakichurna Vati (internally) in the Management of Parikartika w.s.r. to Acute fissure in Ano
No full textBackground: Fissure in ano is longitudinal tear in the lower end of the anal canal and is the most painful condition affecting the anal region. Acute fissure in ano often respond well to conservative measures like adequate fluid intake, fiber rich diet (vegetables, fruits, brown rice), bulk forming agents (Psyllium husk), Laxatives, local anesthetic agents (lignocaine-5%), Sitz bath etc. Surgery for fissure in ano involves Sphincterotomy, Fissurectomy and anal advancement flap is practiced. Bheshaj Chikitsha (~Palliative treatment) is considered as the first line of treatment and Deepan (~appetizers), Pachan (~digestants), Anuloman drugs (~carminatives) are advocated along with local therapies such as Basti (~medicated enema) and Guda Pichu (~oil-soaked rectal tampons) etc.
Method: This is a single arm clinical interventional study. Total 50 patients of Acute fissure in ano were selected for this study. Patients were treated with Yavadi Ghritam (locally) for 7 days along with Haritakichurna Vati (internally) for 14 days. The parameter such as pain, per rectal bleeding, anal sphincter spasm, size of ulcer and Constipation were assessed before, during and after treatment.
Results: Baseline median scores for pain, constipation, bleeding, sphincter spasm, and ulcer size were 3. By day 3, all parameters improved to a median of 2. By day 7, pain, constipation, bleeding, and sphincter spasm resolved completely (median 0), and ulcer size reduced markedly (median 1).
Conclusion: The prescribed combination therapeutic intervention proved effective in reducing symptoms of Acute fissure in ano such as pain, p/r bleeding, anal sphincter spasm, size of ulcer and constipation
Therapeutic Role of Ayurveda in Chronic Liver Disease: Clinical and Biochemical Outcomes from a Single Case Study
No full textChronic liver disease (CLD) is a progressive condition characterized by long-term deterioration of liver structure and function, often associated with significant morbidity and mortality. Conventional management primarily focuses on symptom control and slowing disease progression, but interest in complementary approaches such as Ayurveda is growing. This case study reports the Ayurvedic management of a 51-year-old male patient diagnosed with CLD, with a history of jaundice and mild esophagitis, treated at Jeena Sikho Lifecare Limited Hospital, Safdarjung, India. The patient presented with complaints of itching over abdomen, reduced appetite, poor digestion, weakness, difficulty in walking, disturbed sleep, vomiting, and nausea, with pale skin and eyes on examination. Ayurvedic diagnosis correlated the condition with Yakrit Vikara and Kumbhakamala, involving predominant Pitta Dushti along with Kapha and Vata in the chronic stage. The therapeutic approach included Pitta Shamana, Agni Deepana, Ama Pachana, Rakta Shodhana, and Yakrit Poshana, supported by a Pitta-pacifying diet, lifestyle modifications, and gentle Yoga. Following treatment, the patient experienced marked improvement in subjective and objective symptoms. Itching resolved completely, appetite and digestion normalized, weakness subsided, sleep improved from a reduced score of 3/10 to 8/10, and nausea subsided. Biochemical parameters showed substantial hepatic recovery, total bilirubin decreased from 25.30 mg/dL to 1.64 mg/dL, direct bilirubin from 23 mg/dL to 1.58 mg/dL, and indirect bilirubin from 2.3 mg/dL to 0.06 mg/dL. Liver enzymes improved, with SGOT dropping from 141 IU/L to 45.80 IU/L and SGPT from 91.60 IU/L to 27.90 IU/L. Total protein rose from 5.19 g/dL to 6.02 g/dL. This case underscores Ayurveda’s potential to provide symptomatic relief and enhance liver function in CLD, warranting further research through controlled clinical studies
A Randomized controlled clinical study to evaluate the wound healing activity of Durvadi Ghrita in Clean wounds w.s.r to Shuddha Vrana
Get PDFIntroduction: The wound which is referred as Vrana is the oldest ailment from which the humankind has suffered. Man has made every effort to deal with the problems caused by trauma since the dawn of civilization. A thorough analysis of the Ayurvedic classics revealed that Durva is one of the medications with wound-healing capabilities. Objective: To evaluate the wound healing activity of Durvadi Ghrita in Clean wounds. Methodology: A single blind clinical study with pre-test and post-test design. The 30 patients with diagnostic criteria of Shuddha Vrana were selected from R.G.G.P.G. Ayurvedic College, Paprola, District Kangra, Himachal Pradesh. In Group A, the wound is dressed with Povidone Iodine. In the group B, Durvadi Ghrita was used for dressing. Wound management done once in a day. Duration of the study was 28 days. Follow up done once in 7 days for 1 month. The data were graded based on the assessment criteria and were analysed statistically. Results: The outcome of the treatment after 28 days showed high statistical significance in parameters like color (vrana) ,wound bed , sourrounding skin, type and amount of discharge from the wound and pain . Conclusion: Both these treatments showed reduction in symptoms but Group B in which Durvadi Ghrita was used showed better results. It can be concluded that Durvadi Ghrita is very effective in the management of Shuddha Vrana when compared to Povidone Iodine
An Ayurvedic holistic approach in achieving hormonal balance in a co-existing condition of PCOS and Hypothyroidism - A Case Report
Get PDFIntroduction: PCOS and thyroid hormonal imbalances are very much prevalent co-existing endocrinal conditions of recent days. Holistic approaches of Ayurveda offer cost effective and promising solutions to these kinds of multi-systemic conditions. Case Details: A female patient aged about 23years, diagnosed with Hypothyroidism and PCOS associated with severe craving, thirst, lethargy, sleep disturbance and irregular periods characterized by Amenorrhea for six to nine months with very minimal menstrual bleeding. Detailed analysis of Hetu, Lakshana based on Trividha, Astavidha, Dashavidha Pareeksha, revealed Kapha and Vata Nidana causing Arthavavaha Srotosangha and Rasa-Medo Dhatu Dushti. Accordingly, the treatment approach was planned with Nidana Parivarjana, Deepana, Pachana, Shodhana (Vamana), Samsarjana followed by Shamana and regular Suryanamaskara with morning relaxing walk and exercises. Results: A significant result was noted during treatment in terms of reduction in severe craving, thirst, lethargy, sleep disturbance and level of TSH from 3.01µIU/ml (with thyroid hormonal medication) to 1.71µIU/ml (without thyroid hormonal medication) body weight reduced from 63kgs to 59kgs BMI from 27.3 to 25.5 with the appearance of regular menstrual cycle thereafter. Conclusion: A satisfactory improvement observed in overall health of the patient proving significant efficacy of principle based holistic approach of Ayurveda for multi systemic hormonal balance
Role of Ayurveda in management of Ovulatory Factor Infertility Associated with Hyperprolactinemia: A Case Report
Get PDFInfertility affects approximately 17.5% of the global adult population, with about 8% of currently married women in India being infertile, most are experiencing 2° infertility (5.8%). Ovulatory abnormalities account 25% of all causes of female infertility. Hyperprolactinemia (HPRL) causes infertility by suppressing the hypothalamic-pituitary-gonadal axis, which reduces ovarian estrogen release, resulting in anovulation and infertility. Infertility develops from oligo-ovulation or anovulation since no oocyte is released, thus there is no chance of fertilization. This can be understood as Artava Dushti from classical Ayurvedic perspective associated with Rasa Dhatva Agni Mandya. The treatment principles lie in regulating the Agni followed by alleviating the Kapha which obstructs the Strotas. A 40-year-old female patient present with complaint of unable to conceive since 7yrs despite regular unprotected intercourse, with additional complaints of bloating, body heaviness, and headaches during menstruation. She was diagnosed with PCOD in 2017 and underwent ovarian drilling and unsuccessful fertility treatments, including IUI and ICSI. Then she approached SJSACH OPD for further treatment where she was diagnosed with HPRL and Hypothyroidism. The patient underwent Vamana as Shodhana Chikitsa followed by Shaman Chikitsa, resulting in a significant reduction in TSH and prolactin levels, leading to normal ovulation. Hence conditions of Anovulation which are associated with endocrinal anomalies like HPRL, Hypothyroidism can be managed with proper Ayurvedic diagnosis and treatment. In the present scenario, patient was treated with an initial round of counseling followed by Shodhana and Shaman Chikitsa which is proper utilization of Satwa-Avachaya Chikitsa followed by Yukti-Vyapasharya Chikitsa