Journal of Ayurveda and Integrated Medical Sciences (JAIMS)
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A Pharmaceutical Study of Triphaladi Vati on Mukhapaka Treatment w.s.r. to Tobacco Induced Stomatitis
No full textRationale: Mukhapaka (Tobacco induced Stomatitis), (Pitta& Kapha Dosha vitiation mainly), characterized by locally with Paka (mouth ulcer/ leukoplakia), Lalima (redness), Ksharokshit Kshat Sam (erosion of oral mucosa), Tikta Vaktrata (bitter taste), Peeda (pain), Daha (burning sensation), and difficulty in chewing hot things etc. Regular use of Tobacco acts as a slow poison (chronic toxicity), produces Jatharagni Mandhya (suppresses the digestive fire), Hriddaurbalya, Koshthabaddta/ Atisaar and Srotovalepa (blockage of the body channels). Aim & Objectives: To understand the pharmaceutical preparation and action of Triphaladi Vati in Mukhapaka (Tobacco induced Stomatitis) and mode of action on each symptom. Material & Methods: Triphaladi Vati is an herbal combination cited in Astang Hrdaya Uttar Sthana, for all critical Rogas of kantha, Austha, Talu. Especially it treats Rohini, Mukha Shosha and Gandha Rogas. Triphaladi Vati contains Triphala, Bhunimb, Chitraka etc. 22 drugs. Discussion: The medicinal formulation should mostly improve the quality of Rasa, Rakta and Mamsa Dhatus and should have Deepaniya, Pachaka, Virechaka, Rasayana, Twagdoshahar, Hridya, Grahi and Vedna Shamaka properties. Conclusion: All the drugs of Triphaladi Vati fulfill the requirement and help to treat Mukhapaka
A case report of Ek-Kushtha with special reference to Psoriasis
No full textPsoriasis is a chronic, immune-mediated skin disorder marked by erythematous, scaly plaques and recurrent flares. In Ayurveda, it resembles Ek-Kustha, a Tridoshaja condition with predominance of Vata and Kapha. This case reports a 33-year-old male with widespread scaly lesions, itching, and skin discoloration, unresponsive to allopathic treatment. An Ayurvedic protocol was implemented, beginning with Deepana-Pachana, Shodhana and Shamana Aushada. This regimen led to a reduction in PASI score from 46 to 1.3, with notable relief in itching, scaling, and discoloration, demonstrating the effectiveness of classical Ayurvedic interventions in managing chronic psoriasis
Integrative Ayurvedic management of Khalitya (Hair Fall) using Gunjadi Taila, Amalaki Rasayana, Arogya Vardhini Vati, Saptamruta Loha and Prachhanna Karma - A Case Report
No full textBackground: Khalitya (hair fall) is a common condition described in Ayurveda, often associated with Darunaka (dandruff), Shirah Kandu (scalp itching), and Kesha Rukshata (dryness of hair). Conventional management frequently provides limited results, whereas Ayurvedic interventions offer a holistic approach.
Case Presentation: A 32-year-old male patient presented with complaints of progressive hair fall, scalp itching, dandruff, and dryness of hair.
Intervention: The patient was managed with an integrative Ayurvedic protocol that included local application of Gunjadi Taila, oral administration of Amalaka Rasayana, Arogya Vardhini Vati, and Saptamrita Loha, along with weekly Prachhanna Karma (therapeutic bloodletting).
Outcome: Clinical improvement was assessed using a structured symptom-scoring method before and after treatment. Marked reduction in hair fall, scalp itching, dandruff, and dryness of hair was observed.
Conclusion: This case highlights the effectiveness of a multimodal Ayurvedic regimen in the management of Khalitya. The integrative approach combining Gunjadi Taila, Rasayana therapy, and Prachhanna Karma may serve as a promising therapeutic option for hair fall and associated scalp disorders
The Role of Rasayana Kalpana in Immunomodulation: A Scientific and Ayurvedic Review
No full textRasayana (rejuvenation) therapy in Ayurveda is traditionally prescribed to enhance Ojas (vital essence) and Vyadhikshamatva (disease-resistance). This review synthesizes classical Ayurvedic doctrine and modern clinical studies on Rasayana drugs and formulations with immunomodulatory effects. Ayurvedic texts (e.g. Charaka Samhita describe Rasayanas as Ojovardhaka (promoters of Ojas) that impart Vyadhikshamatva. Modern research has identified immune- enhancing activities of key Rasayana herbs. For example, Ashwagandha and Guduchi have been shown to raise antioxidant enzyme levels (↑SOD, ↓MDA) and modulate cytokines and immune cell profiles in human trials. Clinical studies also report symptom improvements in immunocompromised patients using Tinospora cordifolia extract. Emblica officinalis (Amalaki), rich in vitamin C and polyphenols, exhibits antioxidant and anti-inflammatory properties useful in immune defense. Traditional Rasayana preparations like Chyawanprash (containing Amalaki, Ashwagandha, etc.) have demonstrated immunostimulatory effects (e.g. enhanced NK cell activity and cytokine release) in clinical studies. This review underscores that Rasayana Kalpana (formulations) act via antioxidant, adaptogenic and immunoadjuvant mechanisms, supported by both classical texts and modern evidence, to modulate and strengthen host immunity
An In-Vitro study to evaluate the Anti-Microbial Activity of Coralllocarpus Epigaeus (Rottler) Hook.F.
No full textTraditional medicinal system is mostly engaged with the usage of herbs as a chief source. Using roots as a remedy is effective in many cases. Tuberous roots of Coralllocarpus epigaeus(Rottler) Hook.f. are traditionally used to treat rheumatic diseases, dysentery[1] etc. It is used in folklore practice for the treatment of wounds. Hence, this study was taken to evaluate the antimicrobial action of this drug which might become a potent source of medicine for treatment of Vrana. The ayurveda term Vrana resembles the wound of modern medicine. Dushta Vrana refers to the non-healing wound or ulcer which is characterized by Pooya(discharge)which is like pus. Pyogenic infections are characterized by local inflammation of skin, soft tissue and bodily parts which are mainly caused by invasion and multiplication of pathogenic microorganisms forming abscess and pus. Sepsis occurs when the body overreacts to infection, releasing chemicals into the bloodstream that ultimately cause organ failure and death. In-vitro study using aqueous extract of this drug showed positive results on collected pus samples by inhibiting the microbial growth. Zone of inhibition was observed around the drug
Ayurvedic interventions in Avabahuka (Frozen Shoulder) - A Single Case Study
No full textAvabahuka is a disease described in classical Ayurvedic texts, Acharya Sushruta and other Acharyas have considered Avabahuka as Vatavyadhi, mainly affecting the shoulder joint (Amsa Sandhi). It is specified by pain and stiffness in the shoulder joint, dominant to restricted movement. The condition is caused mainly by Vata Dosha vitiation, especially when aggravated Vata obstructs the normal functioning of the Sira (nerves), Snayu (ligaments), and Sandhi (joints) in the shoulder. This leads to Shoola (pain) and Bahupraavritti Hani (restricted movement of the arm). According to Acharya Charaka Vatavyadhi is described under Ashta Maha Gada. In the present study, patient having the complaints of Pain and stiffness in the left shoulder for 6 months, with restricted range of motion was managed by using Shamana Aushadhis internally along with Patrapottali Pinda Swedana and Nasya Karma, which was significantly beneficial to the patient of Avabahuka i.e., Frozen Shoulder for long time.
Evaluation of efficacy of Hyponidd Tablet in comparison with Metformin: A Randomized Controlled Trial
No full textBackground: Diabetes mellitus (DM) is a major global health challenge, with India bearing one of the highest burdens. Conventional pharmacological therapies such as metformin remain the cornerstone of management but are limited by side effects and narrow focus on glycemic control. Ayurveda offers a holistic approach, integrating herbal formulations, diet, and lifestyle modification. This study evaluated the efficacy of a standardized Ayurvedic tablet compared with metformin in type 2 diabetes mellitus.
Methods: A randomized, double-blind, active-controlled trial was conducted with 150 participants aged 30–70 years, HbA1c 7.0–10.0%, and BMI 20–40 kg/m². Participants were assigned to Arm A (Hyponidd tablets, 450 mg *2, BID) or Arm B (metformin, up to 1000 mg BID) for 12 weeks, with identical lifestyle counseling. Primary endpoint was change in HbA1c; secondary endpoints included fasting plasma glucose (FPG), postprandial glucose (PPG), anthropometrics, hypoglycemia incidence, quality of life.
Results: 142 participants completed the study (72 in Arm A, 70 in Arm B). HbA1c reduction was greater in Arm A (–1.3%) compared to Arm B (–0.8%, p=0.02). FPG decreased by 38 mg/dL in Arm A versus 25 mg/dL in Arm B; PPG decreased by 62 mg/dL versus 40 mg/dL, respectively. More participants achieved HbA1c <7.0% in Arm A (62%) than Arm B (38%).
Conclusion: The Ayurvedic tablet demonstrated superior efficacy and holistic benefits compared to metformin, attributed to synergistic actions of ingredients such as Cassia auriculata, Emblica officinalis, Curcuma longa, Eugenia jambolana, Enicostemma littorale, Melia azadirachta, and Tinospora cordifolia. These findings support Ayurveda as a culturally relevant and scientifically validated strategy for managing type 2 diabetes
Post-Operative Wound Sinus treated successfully with Ksharasutra - A Case Study
No full textA small number of patients manifest wound infections several months to several years after their operation. Causes being bacterial invasion, weakened immune system, advanced age, obesity, poor nutrition, poor glucose control & more. Here is a case of a 40-year-old female with surgical incisional site infection which occurred 5 years after nephrectomy, presented with pus discharge & pain since 1 month. Despite multiple conventional treatments, the patient experienced recurrent infections and incomplete healing. On examination it was found to be a sinus tract on the skin in left lumbar region on the anterior abdominal wall at incision site. In this report the sinus is dealt with a minimal invasive surgical approach i.e., Ksharasutra, by converting sinus into fistulous tract for the management of patient with post operative wound sinus. No re-occurrence or complications occurred throughout 6 months of follow-up. The post-surgical wound sinus was successfully treated with the minimal invasive techniques i.e., Ksharasutra
Ama evaluated by Jihva Pariksha: A Case Study
No full textIn Ayurveda, Agni (digestive fire) is the cornerstone of health, governing digestion, assimilation, and metabolism. Impairment of Agni, particularly Mandāgni (weak digestive fire), leads to improper digestion, resulting in Ama (metabolic toxins) that obstruct bodily channels, disrupt dosha balance, and weaken immunity. This case study highlights the critical role of Agni, the pathogenesis of Ama, and the diagnostic utility of Jihva Pariksha (tongue examination), a non-invasive tool within Aṣṭasthāna Pariksha. In a 30-year-old male office worker who initially manifested with Agnimāndhya, marked by reduced appetite and sluggish digestion, Jihva Pariksha revealed a pale tongue with a thick white coating and scalloped margins, confirming and Ama. Ayurvedic interventions, including Chitrakādi Vaṭi, Trikatu Churna, and dietary modifications aligned with Samsarjana Krama principles, restored Agni and eliminated Ama, with significant improvements in symptoms and tongue characteristics. This study underscores Jihva Pariksha’s efficacy in diagnosing and monitoring Mandāgni -induced Ama
An Open Label Single Arm Clinical Trial of Amapachaka Vati in the Management of Amajirna
No full textIntroduction: Ayurvedic classics emphasize the pivotal role of Mandagni (Digestive impairment) as the root cause of many diseases, including Ajirna (Dyspepsia). Ajirna is classified into various types, Amajirna (Indigestion due to Ama) is one among them. Amajirna dominated by Kapha Dosha, presents with symptoms such as Shophakshigandayo (Swelling of periorbital region and cheeks), Sadhyobhukta Evodgara (Eructation of previous food), Praseka (Salivation), Utklesha (Nausea) and Gaurava (Heaviness in the body). If untreated, it may lead to severe conditions like Alasaka (Intestinal atony) and Vishuchika (Gastroenteritis with piercing pain). Classical Ayurvedic treatments emphasize Amapachana and Agnideepana. Amapachaka Vati is a well-known herbo-mineral formulation indicated in Agnimandhya and Ajirna. Present study was conducted to evaluate the efficacy of Amapachaka Vati in the management of Amajirna. Materials and Methods: The study was an open-label, single-arm clinical trial conducted on patients diagnosed with Amajirna. Participants were administered Amapachaka Vati, and their symptoms were assessed using predefined criteria. Other parameters such as Abhyavaharana Shakti, Jarana Shakti, and Mala Pariksha for Samata were evaluated before and after the treatment. Results: The clinical trial showed highly significant improvement in symptoms such as Sadhyobhukta Evodgara, Praseka and Gaurava. Significant results were observed in Shophakshigandyo and Utklesha. Conclusion: Amapachaka Vati demonstrated a significant therapeutic effect on Amajirna symptoms, with improving Abhyavaharana Shakti, Jarana Shakti, and Mala Pariksha for Samata. Further studies with larger sample sizes and longer durations are recommended to validate these findings and assess long-term efficacy