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Negative Curvature THz Fiber based Biosensor Design and Fabrication for Analysis of Blood Constituents
No full textTerahertz (THz) radiation has recently gained significant attention owing to its potential in sensing, detection, and communications applications. The unique interactions of THz signals with materials, particularly their strong absorption by water, have sparked interest in employing THz technology for cancer detection and biosensing applications. Among recent advancements, hollow-core negative curvature fiber topologies have emerged as a promising candidate for low-loss electromagnetic wave transmission and refractive-index-based sensing. This study aims to explore unique fiber geometries for optimized total loss and sensitivity, enabling improved broadband THz biosensing capabilities. Utilizing a finite element method based electromagnetic solver, comprehensive numerical analyses were executed to design and evaluate performance of elliptical and circular 5-tube negative curvature fiber geometries tailored for THz radiation. Fiber parameters including the core diameter, ring diameter, and cladding thickness were swept to determine the optimal geometry for achieving the lowest total loss. To assess refractive-index-based sensing, individual blood constituents were introduced into the fiber core region. Blood components including water, plasma, hemoglobin, RBCs, and WBCs were numerically examined as fiber core analytes. Uniform relative sensitivities exceeding 90% for all blood constituents are achieved for a broadband frequency interval of 0.5 to 2 THz centered at the targeted frequency of 1 THz. To evaluate the feasibility of fabricating these hollow core fiber designs, they were manufactured using an SLA Resin 3D Printer. Various printing parameters were optimized to create consistent prints. Image analysis software was used to determine what printing parameters resulted in the minimum wall thickness deviation within a print. In conclusion, unique fiber designs were developed to investigate their biosensing potential in blood constituents through THz radiation. The findings of this study pave the way for advancements in THz biosensing technology
Exploring the effects of Gnao1 knockdown on health and longevity of NIH 3T3 cells
No full textAging is associated with increased incidence of chronic health complications such as cancers, cardiovascular disease, neurodegenerative disease, and metabolic disorders. Knockdown of the G alpha subunit gpa-7, an ortholog to Gnao1 in mammals, has been shown to increase life span in C. elegans when the gene is knocked out of this model organism. Gnao1 is a G alpha subunit that, when activated by a G-protein coupled receptor, activates the enzyme adenylyl cyclase, resulting in the production of cyclic AMP (cAMP). The effects of knocking out Gnao1 in NIH 3T3 tissue culture cells were tested using short interfering RNA, in which quantitative PCR revealed a significant reduction in expression. We hypothesize that knockdown of the G alpha subunit will reduce adenylyl cyclase activity, resulting in decreased production of cAMP in phenotypes associated with healthier aging. Future studies will focus on quantifying the knockdown of the Gnao1 gene to evaluate whether the reduction in this G protein signaling results in an increased tolerance to stressors and/or an upregulation of markers associated with increased lifespan
Integrating Doctrine And Diversity Speaker Series: Echoes Of Slavery: A Deep Dive Into The Citing Slavery Project 11-6-2024
Get PDFInvestigating the Trends in the Adoption and Implementation of Sustainable Building Rating Systems: A Critical Analysis of the LEED Rating System
No full textGreen building rating systems have grown exponentially in popularity since the 1990s due to the increasing need to minimize the negative impact of buildings on the environment. These systems provide a framework for healthy, highly efficient buildings, lowering operational costs, and greenhouse gas emissions while improving the quality of buildings for occupants. This study describes the importance of sustainable building rating systems, analyzes the trends in the adoption of the Leadership in Energy and Environmental Design (LEED) rating system, and critiques key factors that influence the adoption of sustainable building rating systems. Cross tabulations and trend analysis were completed to analyze the patterns in the adoption of the LEED rating system. One of the trends was a surge in registration of projects due to anticipated changes to the LEED rating system. The insights generated by this research are valuable resources for fellow investigators seeking updated information on LEED certification practices
Higher Order Mode Analysis in Frequency Selective Negative Curvature Fibers
No full textA novel negative curvature hollow-core fiber is numerically designed capable of filtering specific frequencies. The six-tube silica fiber strongly favors fundamental mode transmission over higher order modes despite uneven positioning of cladding elements
Curious to Curiouser: How Lewis Carroll\u27s Life and Historical Context Changed Perceptions of Alice~ Adventures in Wonderland
Get PDFSPIRITUAL “QUILTING”: How Contemplative Practices Can Deepen and Humanise Understanding(s) of Global Citizenship Education
No full textThis chapter explores research on using Lectio Divina as a pedagogical innovation and how it can be used to promote greater awareness and understanding of Global Citizenship Education (GCE). Why is GCE so vital in K-16 education? In part, because we live in an interconnected and interdependent world, and students and teachers need to be prepared to thrive amid global challenges. GCE is the United Nations Educational, Scientific and Cultural Organization\u27s (UNESCO) response to global challenges. According to UNESCO, “Global Citizenship Education aims to empower learners of all ages to assume active roles, both locally and globally, in building more peaceful, tolerant, inclusive and secure societies”. By integrating key components of GCE into the curriculum, students are equipped to thrive in our global world by developing core competencies of intercultural fluency, empathy, and civic participation. As a result, we create more fully engaged and compassionate communities. Lectio Divina is employed as a pedagogical tool and as a qualitative research methodology for this work. Findings and implications are from interventions with pre-and in-service teachers in graduate education courses, where students participated in activities to promote awareness and understanding of Global Citizenship Education (GCE)