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Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung
No full textIn this study, we designed novel vitamin B12-targeted PEG-poly(GA) copolymers, and evaluated the role of B12-receptor mediated transport in increased cellular internalization in differentiated, polarized Calu-3 cells epithelial model. The formulations generated showed no significant toxicity or lung inflammation following chronic treatment. Taken together the results presented in this study show that vitamin B12 targeted PEG-poly(glutamic acid) copolymers are a potential as a new class of targeted ‘excipients’ for inhalation delivery of protein drugs to the lungs.
Data presented here includes: Real-time polymerase chain reaction (qPCR); Flow cytometry (FACs); Transmission electron microscopy (TEM); Fluorescence Spectrophotometer; Confocal Microscopy
Guide Dogs on Holiday: Guide dog owner experiences in the travel and tourism sector
Get PDFISBN-13 9780853583325This report presents findings from research on the user experience of travelling with a guide dog. Working in collaboration with The Guide Dogs for the Blind Association, the objectives of the project were to investigate guide dog owner confidence in travel situations and to examine the relationship of guide dog ownership to travel behaviour and decision-making. More broadly, the project identified areas of success, as well as key challenges and opportunities for improvement in the travel and tourism sector, and facilitated the exchange of knowledge on practical and legislative/policy issues for travel and tourism providers
(Figure 2) Un-adjusted LA-ICP-MS 4-cm multi-element runs on ice core KCC from Colle Gnifetti
No full text(Figure 7p2) LA-ICP-MS Fe56 measurements (1315-1365) on ice core KCC from Colle Gnifetti
No full textData for: Tracking Holocene palaeostratification and productivity changes in the Western Irish Sea: A multi-proxy record
No full textData from: Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird
No full textData underpinning Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments
No full textWhat to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study
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