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Diatom isotope data and salinity reconstructions from ODP Site 887, subarctic northeast Pacific Ocean
No full textSupporting data for Selective NMR Observation of the SEI–Metal Interface by Dynamic Nuclear Polarisation from Lithium Metal
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Chrisp et al., Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in Hepatic Npas2 knockout mice
No full textSeries of experiments describing behavioural phenotypes in Npas2 conditional knockout mice. Data to be submitted for publication
Used in the paper: "Optimizing Excipient Properties to Prevent Aggregation in Biopharmaceutical Formulations"
No full textParameter files (.gro, .mdp) for the simulation of stabilising excipients, which were used to study protein-excipient interaction and gain insight into their structure-activity relationship.
Protein formulations have issues surrounding their stability; currently, excipients are added to improve their colloidal and conformational stability. These are selected not for their ability to prevent aggregation per se but because of their exemplary safety profile. These excipients (polysorbates, Brij, fatty acid ethoxylates, fatty acids, sugars, liposaccharides, amino acids, phospholipids, glycerides, ceramides) were parameterised in the Martini forcefield or collected from the Martini website in order to be simulated in Gromacs and investigate the interaction between excipients and protein at high resolution, and probe the mechanism of aggregation-prone region shielding. These were used in the study of two proteins: HSA and insulin
Data from: Last Glacial Maximum environmental conditions at Andøya, northern Norway; evidence for a northern ice-edge ecological “hotspot”
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