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2142 research outputs found
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A machine learning pipeline to accelerate the design of in vitro release tests from liposomes
No full textProcessed datasets and code associated with manuscript submission titled "A machine learning pipeline to accelerate the design of in vitro release tests from liposomes"
STADIA SWAT Extended Data
No full textExtended Data for the STADIA SWAT manuscript: Timing and value of participant vouchers to improve questionnaire return rates in the STADIA (STAndardised Diagnostic Assessment for children and adolescents with emotional difficulties) Tria
DFT data for "Metal-free Direct Electrochemical Deoxygenation of Benzylic Alcohols"
No full textThis dataset contains Gaussian DFT output files of the ground-state and transition state DFT optimized structures for the project "Metal-free Direct Electrochemical Deoxygenation of Benzylic Alcohols".
Each of the lower level folders contain the output of a frequency calculation at PBE0-D3/def2-TZVP level with SMD(diethylether) solvent model (*freq001.out files).
All of the files can be opened in any text editor. Gaussian output structures
can be viewed and the frequency modes visualised in GausView, Avogadro, jmol
and in most other molecular viewers/editors.
Dataset also contains analytical data for compounds reported in the publication "Metal-free Direct Electrochemical Deoxygenation of Benzylic Alcohols".
The data is organised into subfolders, which are numbered in accordance with compound numbering in the manuscript and accompanying Supporting Information document.
For each compound, raw data for 1H/13C/19F/31P NMR, MS, IR, GC-MS, and Cyclic Voltammetry are included where relevant
Raw data for new compounds described in the paper "Development of a Multikilogram-Scale One-Pot Albright Goldman Oxidation/Dienol Acetate Formation Sequence for the Synthesis of Noroxymorphone from Morphine"
No full textRaw data for new compounds described in the paper "Development of a Multikilogram-Scale One-Pot Albright Goldman Oxidation/Dienol Acetate Formation Sequence for the Synthesis of Noroxymorphone from Morphine
Philosophy programs in prison and rehabilitative outcomes – protocol for a scoping review
Full text linkPRISMA compliant protocol for a scoping review to identify and report research evidence, nationally and internationally, on the impact of philosophy programs in prison on rehabilitative outcomes, and second to consider, where possible, which interventions or aspects of those interventions facilitate or hinder their effectiveness. This will enable providers to adopt the most effective methods for developing and implementing such programmes and support further research by identifying gaps in knowledge
Wound-Healing Biodegradable Microparticles: An In Vitro Investigation
No full textWound healing is a complex process that may result in healthy tissue regeneration, but problematic chronic wounds exhibit fibrosis and persistent inflammation. To improve wound outcomes, the application of pro-proliferative polymers as bioresorbable particles was investigated for the first time. The surface of bioresorbable poly (D, L lactic acid) (PDLLA) microparticles are decorated with a pro- and anti-proliferative polymer that adheres to the surface for a minimum of 21 days. Microparticles with a pro-proliferative polymer surface chemistry were shown to increase fibroblast proliferation in vitro by 5-fold % after 48 hours compared to cells without microparticle treatment. The cells are found to move to establish bridges between the microparticles, which facilitate cell elongation and proliferation, accelerating a key stage of the wound healing cycle. Adsorbed proteins were examined using proteomics and unique proteins were found to adhere to microparticles with proliferative surface chemistry. These proteins include annexin, olfactomedin 4 and vimentin, and the roles of these proteins have been highlighted to gain a mechanistic insight into the stimulated proliferative environment causing by the microparticles. The lipid deposition/retention from exposure to culture media of microparticles is investigated by 3D OrbiSIMS and highlights preferential adsorption of lipid, including sterols, fatty acids and sphingolipids, correlates with pro and anti-healing polymers. This mechanistic insight helps advance this technology to address the pressing issue of chronic wound healing.
Molecular orientation and stratification revealed in RNA-lipid nanoparticles using Cryogenic Orbitrap Secondary Ion Mass Spectrometry (Cryo-OrbiSIMS)
Full text linkLipid nanoparticle-RNA formulations are used for the delivery of vaccines and other therapies. RNA molecules are encapsulated within their interior through electrostatic interactions with positively charged lipids. The identity of the lipids that present at their surface play a role in how they interact with and are perceived by the body and their resultant potency. To investigate the surface chemistry of two formulations we develop cryogenic sample preparation for transmission electron microscopy (TEM) prior to depth profiling Orbitrap secondary ion mass spectrometry (Cryo-OrbiSIMS). It is found that the depth distribution of individual lipid components is revealed relative to the surface and the RNA cargo defining the core. A preferential lipid orientation can be determined for the 1,2-Dimyristoyl-glycero-3-methox-polyethylene glycol 2000 (DMG-PEG2k) molecule, by comparing the profiles of different fragments from the same molecule, from PEG or DMG. PEG fragments are found at the LNP surface, while the DMG fragments are deeper, coincident with the RNA fragment from the core, in agreement with established models of LNPs. This laboratory-based de novo analysis technique requires no labelling, providing advantages over large facility neutron scattering characterisation
The impact of binders on magnetic framework composite pellets for CO¬2 capture
No full textCharacterisation data and results for research pape
HERE’s What We Know About the Educational Inclusion of Refugees with Disabilities in Europe
Full text linkThe educational inclusion of refugees with disabilities in Europe presents a complex and multifaceted challenge that requires a comprehensive and intersectional approach. This report highlights these challenges and identifies where practices and approaches effectively ameliorate these, based on findings from a scoping review. It underscores the importance of recognising the diverse and compounded identities of refugee learners with disabilities, who face unique barriers that intersect across disability, migration, language, and socio-economic status. Overall, the report calls for a comprehensive and intersectional approach to inclusive education for refugees with disabilities, and highlights specific areas of focus for future research, policy, and practice to ensure that these learners receive the support they need and are entitled to, to thrive in their educational journeys
