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A pilot study to identify MRI derived imaging features that drive the significant association between brain health and dementia related risk factors
No full textThe study protocol for a pilot study to identify the MRI based imaging derived phenotypes which drive the significant association between brain health and modifiable risk factors that related to dementia
Privacy-Preserving Detection of Online Misinformation
No full textThis repository contains data collected during a user study for a TAS-funded project on the privacy-detection of online misinformation
Investigating the link between brain maturation imbalance, impulsivity, and suicidal and non-suicidal self-harm behaviour in preadolescent children
Full text linkStudy protocol for investigating the link between brain maturation imbalance, impulsivity, and suicidal and non-suicidal self-harm behaviour in preadolescent children using the ABCD dat
Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipids
No full textThe data here was used to produce the figures in the submission:-
Advanced Science Feb 2024
W. Suvannapruk, L. E Fisher,
J. C Luckett, M. K Edney,
A. M Kotowska, D.-H. Kim, D. J Scurr, A. M Ghaemmaghami,
M. R Alexander* ............ 2306000
Spatially Resolved Molecular Analysis of Host Response to Medical Device Implantation Using the 3D OrbiSIMS Highlights a Critical Role for Lipid
Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient
No full textAdditive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing enables the precise deposition (10-80 µm) of multiple materials, which enables integration of precise doses with tailored release rates; in the meanwhile, this technique has demonstrated its capability of high-volume personalised production. In this paper we demonstrate how two dissimilar materials, one water soluble and one insoluble, can be co-printed within a design envelope to dial up a range of release rates including slow (0.98 ± 0.04 mg/min), fast (4.07 ± 0.25 mg/min) and multi-stepped (2.17 ± 0.04 mg/min then 0.70 ± 0.13 mg/min) dissolution curves. To achieve this, we adopted poly-4-acryloylmorpholine (poly-ACMO) as a new photocurable water-soluble carrier and demonstrated its contemporaneous deposition with an insoluble monomer. The water soluble ACMO formulation with aspirin incorporated was successfully printed and cured under UV light and a wide variety of shapes with material distributions that control drug elution was successfully fabricated by inkjet based 3D printing technique, suggesting its viability as a future personalised solid dosage form fabrication routine
Ethics in the Governance of Data and Digital Technology: An analysis of European Data Regulations and Policies
No full textAddressing ethical concerns is among the fundamental motivations for the development of policies and regulations for data and digital technologies. In the last few years, the European Commission has issued a number of policies, regulations and legislative proposals for socially desirable and legally compliant data governance for technologies which have ethical implications. What is not obvious, however, is whether and in what way ethics are included explicitly in the way these policies and regulations are created and implemented to address data governance challenges. Given the increasing amount of available digital data, its use for AI and other purposes and the growing amount of regulatory activity around data, this paper explores the role ethics plays in these documents. We examined eight of these documents to map the ethical concerns and justifications underlining their provisions, the ethical principles they promote and the implementation approaches recommended. Our analysis shows that the current EU data governance policy landscape can be read from an ethical perspective as being grounded in ethical thinking, typically expressed in terms of human rights, aware of likely concerns, based on well-established principles and in the process of being codified in regulation, legislation and institutions. However, the practical implementation of these principles, for instance how conflicts among these principles can be resolved, remain unclear.
This is the datasets from the research; including the coding tree and analysis of the documents and policies for the researc
Identification of a discrete population of CD8+ effector memory cells linked to immune checkpoint inhibitor-induced liver injury
No full textAnonymised mass cytometry data collected from patients with drug-induced liver injury and autoimmune hepatitis, and associated controls. Data acquired using a Helios mass cytometer on whole blood samples stained using the Maxpar Direct Immune Profiling assay kit. Samples have been preprocessed (normalisation, gating on gaussian parameters and live/dead stain), and values have been arcsinh transformed with a cofactor of 5, no further filtering or clustering has been carried out
Raw data for new compounds described in the paper "Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans"
No full textRaw data for new compounds described in the paper "Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans
Data used in “An Investigation into the Erosion and Wear Mechanisms Observed in Abradable Ytterbium Disilicate Environmental Barrier Coatings”
No full textWear test data used in “An Investigation into the Erosion and Wear Mechanisms Observed in Abradable Ytterbium Disilicate Environmental Barrier Coatings
Emotion, Action and Power in the Penal Voluntary Sector, 2019- 2020
No full textThis deposit contains the signed consent forms for the qualitative data conducted for this study.
For queries regarding access to these files please contact Professor Philippa Tomczak at [email protected]