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Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth.
No full textExosomes are small extracellular microvesicles that are secreted by cells when intracellular multivesicular bodies fuse with the plasma membrane. We have previously demonstrated that Nischarin inhibits focal adhesion formation, cell migration, and invasion, leading to reduced activation of focal adhesion kinase. In this study, we propose that the tumor suppressor Nischarin regulates the release of exosomes. When cocultured on exosomes from Nischarin-positive cells, breast cancer cells exhibited reduced survival, migration, adhesion, and spreading. The same cocultures formed xenograft tumors of significantly reduced volumefollowing injectionintomice. Exosomes secreted by Nischarin-expressing tumors inhibited tumor growth. Expression of only one allele of Nischarin increased secretion of exosomes, and Rab14 activity modulated exosome secretions and cell growth. Taken together, this study reveals a novel role for Nischarin in preventing cancer cell motility, which contributes to our understanding of exosome biology. Significance: Regulation of Nischarin-mediated exosome secretion by Rab14 seems to play an important role in controlling tumor growth and migration
Jet Magazine: Celebrating Black Female Beauty
Get PDFOnce referred to as, “the Negro bible” by famed actor and comedian Redd Foxx[1], Jet has continued to be a pioneer in representing Black Americans as beyond the stereotypes to which they are so often relegated. The magazine has not only provided accurate coverage throughout momentous Black historical movements such as the Civil Rights Movement in the 1950s, the Black is Beautiful movement of the late 1960s, and the Natural Hair Movement of the 2000s, but it has also catered to the daily interests of Black Americans, such as fashion and beauty, lifestyle advice, dating advice, politics, health and diet guides, and coverage of popular actresses and actors of the time. Jet has prided itself on instilling in Black women “confidence and strength” through their representations of Black women. Comparison of the portrayals of Black women in Jet articles, advertisements, and illustrations published in the years 1950-1955, 1970-1975, 1990-1995; years during which the beauty standard of America was very Eurocentric and did not stray from that line; shows that Jet Magazine was one of the first publications to depict Black women as inherently beautiful. Examination of these representations within the historical, political, and psychological contexts of Black culture in America shows the development of Jet as an agent of social reform and change that challenges both the traditional view of Black women and the beauty standards present in American society
Organic Chemistry I Drill (CHEM2210D) - Module 7 - Mechanisms and Substitutions
Get PDFThis module deals with chemical reactivity and mechanisms, and substitution reaction
Organic Chemistry II Drill (CHEM2220D) Module 7. Sample Problems
Get PDFThis module teaches carboxylic acids and their derivatives
Organic Chemistry II Drill (CHEM2220D) Module 7. Sample B. Answer Key
No full textThis module teaches carboxylic acids and their derivatives
Organic Chemistry II Drill (CHEM2220D). Module 2. Sample B. Answer key
Get PDFThis module teaches about alcohols and phenols; ethers and epoxides; thiols and sulfides
Organic Chemistry II Drill (CHEM2220D). Module 3. Conjugate Systems and Pericyclic Reactions
Get PDFThis module teaches conjugated \u27PI\u27 systems and pericyclic reactions
Organic Chemistry II Drill (CHEM2220D). Module 4. Sample B. Answer Key
No full textThis module teaches about aromatic compounds