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    898 research outputs found

    Organic Chemistry I Drill (CHEM2210D) - Module 4 - Nomenclature

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    This module teaches Nomenclature

    Organic Chemistry I Drill (CHEM2210D) - Module 4 - Sample Problems

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    This module teaches Nomenclature

    Organic Chemistry Drill (CHEM 2220D). Module 9. Sample Problems.

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    This module teaches how the student can draw the structure given the name of amines and common nitrogren heterocycles. (Pyrrole, Pyridine, Purine, Pyraminidine, Imidazole

    McNair Collection, 2019 - Poster Presentation

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    A poster presentation from National Conference for McNair Scholars and Undergraduate Research, 20th, 2019 at University of Maryland, College Park, Maryland.https://digitalcommons.xula.edu/mcnair_conf/1003/thumbnail.jp

    Data Management Introduction

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    Data Management Introductionhttps://digitalcommons.xula.edu/data_instruct/1001/thumbnail.jp

    McNair Program - Projects with a Purpose - Dr. Melvinia M. Martin\u27s Students - Group Photo # 9

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    Group photograph of McNair Scholars engaged in a community project. This photograph includes a person carrying a wooden pole and another person wearing a red t-shirt.https://digitalcommons.xula.edu/mcnair_service/1010/thumbnail.jp

    Claude Albritton, with a Black Bookbag

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    A photograph of Claude Albritton, a McNair Scholar, with a Black Book bag.https://digitalcommons.xula.edu/mcnair_schol/1001/thumbnail.jp

    The More Things Change

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    Proteomics-Metabolomics Combined Approach Identifies Peroxidasin as a Protector Against Metabolic and Oxidative Stress in Prostate Cancer.

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    Peroxidasin (PXDN), a human homolog of Drosophila PXDN, belongs to the family of heme peroxidases and has been found to promote oxidative stress in cardiovascular tissue, however, its role in prostate cancer has not been previously elucidated. We hypothesized that PXDN promotes prostate cancer progression via regulation of metabolic and oxidative stress pathways. We analyzed PXDN expression in prostate tissue by immunohistochemistry and found increased PXDN expression with prostate cancer progression as compared to normal tissue or cells. PXDN knockdown followed by proteomic analysis revealed an increase in oxidative stress, mitochondrial dysfunction and gluconeogenesis pathways. Additionally, Liquid Chromatography with tandem mass spectrometry (LC-MS/MS)-based metabolomics confirmed that PXDN knockdown induced global reprogramming associated with increased oxidative stress and decreased nucleotide biosynthesis. We further demonstrated that PXDN knockdown led to an increase in reactive oxygen species (ROS) associated with decreased cell viability and increased apoptosis. Finally, PXDN knockdown decreased colony formation on soft agar. Overall, the data suggest that PXDN promotes progression of prostate cancer by regulating the metabolome, more specifically, by inhibiting oxidative stress leading to decreased apoptosis. Therefore, PXDN may be a biomarker associated with prostate cancer and a potential therapeutic target

    Mardi Gras Indians Super Sunday Celebration at Uptown New Orleans.

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    The New Orleans Mardi Gras Indian Super Sunday is an important day during carnival is celebrated near St. Joseph\u27s Day. The Mardi Gras Indian parade through the streets of New Orleans wearing their fabulous costumes. This particular video shows the parade through Uptown New Orleans an area bound by Napolean Ave, Magazine Street, Jefferson Avenue and La Salle Street.https://digitalcommons.xula.edu/masked/1017/thumbnail.jp

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