Indonesian Journal of Medicine (IJM)
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Convalescent Plasma Treatment for Moderate to Critical Ill COVID-19 Patients – A Safe but Futile Treatment: A Non-Randomized Comparative Study
Get PDFBackground: In a number of cases of viral infection, convalescent plasma therapy has been effective. Reportedly, the use of convalescent plasma as a therapy for COVID-19 patients with severe and life-threatening disorders is beneficial at this time. This study aims to assess the effectiveness and safety of convalescent plasma transfusions in hospitalized COVID-19 patients.
Subjects and Method: This was a clinical trial employing a non-randomized comparative study. A historical control group (21 samples) and convalescent plasma transfusions (21 samples) was selected consecutively from hospitalized COVID-19 patients between May 6th, 2020, and May 6th, 2021 at Dr. Moewardi General Hospital. We assessed and quantified viral clearance in the laboratory. Statistical analysis is performed in SPSS version 20.0.
Results: Plasma was taken from fifteen convalescent donors. In the plasma convalescent treatment group, there was a statistically significant difference between outcome and severity degree (p = 0.005). In addition, there was a substantial discrepancy between the result group and the control group (p 0.005). Significant differences in post-treatment NLR between the control and treatment groups (p 0.005). In addition, there were statistically significant differences between the control and treatment groups in post-treatment hsCRP levels (p 0.005). In addition, there were statistically significant differences (p 0.005) between all groups' inflammatory markers and outcomes.
Conclusion: Using convalescent plasma to treat patients with COVID-19 is a rather safe practice. Our analysis demonstrated that the administration of convalescent plasma did not enhance survival or clinical outcomes for COVID-19 patients with moderate to severe disease.
Keywords: COVID-19, convalescent therapy, critical il
Difference in the Effect of Giving Neck Stabilization Exercise with Stretching on Improvement of Neck Functional Ability in Non-Specific Neck Pain
Get PDFBackground: Tailor workers when working with a bowed position and a long static position, the muscles will contract excessively resulting in spasms and pain that causes non-specific neck pain which will interfere with the functional ability of the neck. Neck stabilization exercises and stretching can be exercises to improve neck functional ability in non-specific neck pain. This study aims to determine the difference in the effect of neck stabilization exercise and stretching on increasing the functional ability of the neck in non-specific neck pain.
Subjects and Method: This study is a randomized controlled trial using a two-group pretest and post-test design conducted at sevinta convection and padi emas from November to December 2023. A total of 24 subjects were selected by random sampling and randomly allocated into 2 groups. Group 1 was given neck stabilization exercise and group 2 was given stretching. The dependent variable is neck functional ability in non-specific neck pain and the independent variables are neck stabilization exercise and stretching. The measuring instrument used is the neck disability index to measure neck functional ability. Data analysis using independent sample t-test.
Results: The results after the intervention obtained neck functional ability in non-specific neck pain increased in both groups. There is a statistically significant difference in neck stabilization exercise (Mean = 4.00; SD = 2.21) and stretching (Mean = 6.83; SD = 2.79), and it was statistically significant (p = 0.012).
Conclusion: There is a significant difference in the effect of neck stabilization exercise and stretching on improving neck functional ability in non-specific neck pain. Neck stabilization exercise is more influential than stretching on improving neck functional ability in non-specific neck pain.
Keywords: neck stabilization exercise, stretching, neck disability index.
Correspondence: Yulianto Wahyono, School of Health Polytechnics Ministry of Health Surakarta. Jl. Adi Sumarmo, Tohudan, Colomadu, Karanganyar 57173, Central Java, Indonesia. Email: [email protected]. Mobile: 085742017903.
Indonesian Journal of Medicine (2023), 08(03): 258-26
Effect of Gluten Free Casein Free Diet on Maladaptive Behavior in Autistic Children: Meta-Analysis
Get PDFBackground: Children with Autism tend to experience gastrointestinal disorders more often. Interactions between the gut and brain microbiome influence mood and behavior in health and disease. Diet therapy, specifically the gluten and case-free diet (GFCF) is an elimination diet that involves removing certain proteins from the normal diet, such as gluten and casein. The right intervention can change behavior for the better and through the right handling. This study aims to estimate the effect of a case-free gluten-free diet on maladaptive behavior in autistic children, through a meta-analysis of primary studies conducted by previous authors.
Subjects and Method: This study is a systematic review and meta-analysis with the following PICO, population: Autism children, intervention: gluten-free case-free diet, comparison: no case-free gluten-free diet, outcome: maladaptive behavior. The articles used in this study were obtained from three databases, namely PubMed, Google Scholar, and Science Direct, using the search key “Diet Gluten Free Casein Free” OR “NonDiet Gluten Free Casein Free” OR “GFCF” AND “Autism” OR “Autism” AND “Maladaptive” AND “Randomize Controlled Trial” OR “RCT”. The included article is a full-text Randomized Controlled Trial study designed from 2002 to 2022 and reports the mean and SD in multivariate analysis. The selection of articles is done using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.4 application.
Results: A total of 7 randomized controlled trial studies conducted in the Americas, Europe, and Asia were selected for meta-analysis. Autistic children who received casein-free gluten-free had an average score of 0.11 units of maladaptive behavior lower than those who were not given a diet (SMD= 0.11 95% CI= .035 to 0.13; p= 0.360).
Conclusion: The casein-free gluten-free diet has an effect on reducing the risk of maladaptive behavior in children with autism.
Keywords: casein free gluten-free diet, gfcf, maladaptive behavior, autism
Correspondence: Ruliany Yuni Nurul Hakim. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57126, Central Java, Indonesia. Email: [email protected]. Ponsel +6282124886320.
Indonesian Journal of Medicine (2023), 08(03): 28629
Effectiveness of Indoor Residual Spraying as A Method of Controlling Dengue Fever in Communities: A systematic review
Get PDFBackground: Dengue remains a significant public health issue in the Western Pacific Region. In the absence of a vaccine, vector control is the mainstay for dengue prevention and control. This study aimed to explore the effectiveness of Indoor Residual Spraying as A Method of Controlling Dengue Fever in Communities.
Subjects and Method: A systematic review was conducted by searching articles from PubMed, ResearchGate, Science Direct, Google Scholar, and EBSCO is an article published from 2013 to 2023. The keywords were “dengue hemorrhagic fever” OR “DHF” AND “community” OR “family” AND “disaster” AND “IRS” OR “indoor residual spraying”. The inclusion criteria were a Cross-sectional study. The articles were selected by PRISMA flow diagram method.
Results: A total of 9 studies were included in this review. All of the studies stated that IRS can have both an immediate and sustained effect on reducing adult and immature A. aegypti populations and should be considered as an adult mosquito control strategy by dengue vector control programs also IRS led to 86-96% reduction in dengue cases in sprayed premises, compared to unsprayed controls.
Conclusion: IRS significantly reduces the malaria burden in high-transmission settings.
Keywords: dengue hemorrhagic fever, DHF, family, community.
Correspondence: Titik Anggraeni. School of Health Sciences Estu Utomo Boyolali, Central Java, Indonesia. Jl. Tentara Pelajar 7, Mudal, Boyolali, Central Java, Indonesia. Email: [email protected]. Mobile: +62 858-6729-2673.
Meta-Analysis: The Effect of Acupuncture Therapy in Reducing Migraine Recurrence
Get PDFBackground: Acupuncture therapy is an effective treatment for reducing headache intensity, migraine recurrence, and improving quality of life. This study aims to analyze and estimate the effect of acupuncture therapy on reducing migraine recurrence.Subjects and Method: This study used a systematic review and meta-analysis by following PICO, Population: migraine patients. Intervention: acupuncture therapy. Comparison: no acupuncture therapy. Result: reduction in migraine recurrence. The data used were obtained from scientific research articles from the Pubmed, Google Scholar, Science Direct, and SpringerLink electronic databases with a Randomized Control Trial (RCT) design from 2011 to 2022 which reports effect sizes with Mean and SD. The keywords used in the search for scientific articles are “Acupuncture” AND “Profilaxis Migraine” AND “Migraine Frequency”. The selection of articles was carried out using the PRISMA flowchart. Data were analyzed using Review Manager software version 5.4.1.Results: A total of 9 articles with qualified RCT designs from Asia, America, Australia, and Europe were selected for the systematic review and meta-analysis. The results of the meta-analysis showed that patients with migraine who received acupuncture therapy experienced migraine recurrence 0.31 units lower than those who were not treated with acupuncture (SMD= -0.31; 95% CI= -0.61 to -0.01; p=0.040).Conclusion: Acupuncture therapy reduces migraine recurrence.Keywords: acupuncture, relapse, migraine.Correspondence: Elsa Tursina. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: [email protected]. Mobile: +6285655751077.Indonesian Journal of Medicine (2023), 08(01): 47-58https://doi.org/10.26911/theijmed.2023.08.01.05
Relationship between Social Support and COVID-Related Common Mental Disorders Incidence in Pregnant Women in Banyumas, Central Java
Get PDFBackground: Social restriction and distancing were enforced, to contain the viral transmission of Coronavirus Disease-19 (COVID-19). Therefore, normal social activities are stagnant and give rise to common mental disorders (CMDs) in pregnant women, especially in the first trimester of pregnancy. The purpose of this study was to analyze the relationship of social support with COVID-related common mental disorders (CMDs) in pregnant women in Banyumas Regional General Hospital.Subjects and Method: A observational analytic study using a Cross-sectional study approach targeting pregnant women in the Banyumas Regency Central Java, from May to December 2022. The independent variable is social support. The dependent variable is common mental disorders (CMDs). The sampling technique used snowball sampling of approximately 1543 respondents. This study employed the WHO-SSQ-6 and WHO-SRQ-20 questionnaires. The data analysis technique made use of the Chi-Square test.Results: Pregnant women who have low social support have a risk of Common Mental Disorders (CMDs) and are statistically significant (PR= 1.74; 95% CI = 1.83 to 1.87; p<0.001).Conclusion: Social support has a significant correlation with COVID-related CMDs.Keywords: COVID-19, COVID-related CMDs, Pregnant women, first trimesterCorrespondence: Yudhi Wibowo, Department of Public Health and Community Medicine, Faculty of Medicine, Jenderal Soedirman University. Jl. Dr. Gumbreg No.1, South of Purwokerto, Banyumas Regency, Central Java. Email: [email protected]. Mobile: +62 811-2621-904.Indonesian Journal of Medicine (2022), 08(02): 142-149https://doi.org/10.26911/theijmed.2023.08.02.0
The Effect of Ambon Banana Juice (Musa paradisiaca var. Sapientum Linn) and Sweet Starfruit Juice (Averrhoa carambola L) on Changes in Blood Pressure in the Elderly Men in the Community Health Center Work Area Tarus, Kupang Regency
Get PDFBackground: Hypertension is a health problem that often occurs in society. Uncontrolled hypertension can trigger degenerative diseases such as heart disease and kidney failure. One of the therapies used to lower blood pressure is Ambon banana and sweet star fruit therapy.
Subjects and Method: Research on elderly men suffering from hypertension in the Tarus Community Health Center working area used a Quasi-Experimental pretest–posttest with a Control Group research design. The number of samples in this study was 20 elderly men using a simple random sampling method. The dependent variable in this study was blood pressure, while the independent variable was the administration of Ambon banana juice, sweet star fruit juice, and a combination of Ambon banana juice and sweet star fruit juice. The measuring instrument used in this research is a questionnaire. The data analysis used in this research is Anova and Post hoc.
Results: The average blood pressure in the elderly decreased after being given Ambon Banana Juice, Sweet Starfruit Juice, and a combination of Juices. The greatest reduction in blood pressure occurred in the group given Ambon banana juice (Mean= 140 mmHg; p=0.002), compared to sweet starfruit juice (Mean= 148 mmHg; p= 0.036), and these results were statistically significant. The juice combination also reduced the average blood pressure, but the results were not statistically significant (Mean= 156 mmHg; p= 0.454).
Conclusion: The average blood pressure in the elderly decreased after being given Ambon Banana Juice, Sweet Starfruit Juice, and a combination of Juices.
Keywords: hypertension, Ambon banana juice, sweet star fruit juice
Correspondence: Nusthen Aries Manek. Universitas Negri Nusa Cendana Kupang. Jl. Adisucipto Penfui, Kupang, Nusa Tenggara Timur. Email: [email protected]. Mobile: 082144927619
Effect of Acupressure on Blood Glucose Level in Diabetes Mellitus Patients: Meta-Analysis
Get PDFBackground: Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from abnormalities in insulin secretion that affect blood sugar levels. Chronic hyperglycemia in DM is associated with long-term damage to several organs of the body. One of the interventions that can be given to lower blood sugar levels is acupressure therapy. The purpose of this study was to determine the effect of acupressure therapy on blood sugar levels in patients with diabetes mellitus.Subjects and Method: This study is a systematic review and meta-analysis with PICO, P: Diabetes mellitus patients, I: Acupressure, C: No acupressure, O: Blood sugar levels. The process of searching for articles is done through a database of journals including: Pubmed, Google Scholar, Science Direct, Scopus, Spinger Link, CNKI and Hindawi. The keywords used in the literature search were: “acupressure” AND “diabetes” AND “blood sugar” AND “blood glucose” AND “standard controlled trial”, “acupressure for diabetes”, “diabetes standardized controlled trial”, “acupressure randomized controlled trial”. trial”, diabetes acupoint, “diabetes and placebo”, “acupressure” AND “diabetes”. The articles included in the study were full text articles with a randomized controlled trial study design and the results were reported with the effect size, mean standard deviations (SMD). Articles were collected using PRISMA flow diagrams and analyzed using the Review Manager 5.3 application.Results: A meta-analysis of 9 articles reviewed in this study came from Taiwan, China, Indonesia, Egypt and Iran with a sample size of 451. The study results showed that acupressure therapy was able to reduce blood sugar levels in diabetes mellitus patients with SMD blood sugar values. acupressure was 0.56 units lower than no acupressure and was statistically significant with a significance value of (SMD=-0.56; 95% CI= -0.76 to -0.37; p<0.001).Conclusion: Acupressure therapy has the effect of lowering blood sugar levels in diabetes mellitus patients.Keywords: acupressure, blood sugar, diabetes mellitus.Correspondence: Muslihatin Khuril Rosyida. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: [email protected]. Mobile: 08564713149.Indonesian Journal of Medicine (2023), 08(01): 68-78https://doi.org/10.26911/theijmed.2023.08.01.0
The Difference of Neiguan Acupressure Points (Pc6), Hypnotherapy, and Hypnopressure in Reducing Anxiety of Hemodialysis Patients
Get PDFBackground: The anxiety felt by patients undergoing hemodialysis can decrease the quality of life, cause a sleep disorder, and even aggravate the disease. Acupressure, hypnotherapy, or hypnopressure have minimal side effects and are easy to do in reducing anxiety. The study aims to analyze the different effects of acupressure, hypnotherapy, and hypnopressure in reducing anxiety in patients undergoing hemodialysis programs.Subjects and Method: It was an experimental study using a randomized controlled trial. It was conducted at Dr. Moewardi Hospital Surakarta, Central Java. The number of study subjects from March 2021 - July 2022 was 300 patients undergoing the hemodialysis program, with 75 subjects obtaining acupressure intervention, 75 subjects obtaining hypnotherapy intervention, 75 subjects obtaining hypnopressure intervention, and 75 subjects obtaining standard/control treatment. The sampling technique used was purposive sampling. The dependent variables in this study were acupressure, hypnotherapy, and hypnopressure, while the independent variable was the anxiety of patients who underwent a hemodialysis program for less than a year or less than 10 times. Anxiety was tested using the Hamilton Rating Scale for Anxiety questionnaire. Data analysis was conducted using an independent t-test, with the SPSS statistics program.Results: Post-acupressure anxiety score (Mean= 17.31; SD= 3.22) was lower than pre-acupressure (Mean= 23.17; SD= 2.68) and the result was statistically significant (p<0.001). Post-hypnotherapy anxiety score (Mean= 15.13; SD= 2.83) was lower than pre-hypnotherapy (Mean= 23.09; SD= 2.38), and the result was statistically significant (p<0.001). anxiety score after hypnopressure (Mean= 12.64; SD= 2.23) was lower than before hypnopressure (Mean= 23.13; SD= 2.53) and the result was statistically significant (p<0.001).Conclusion: Hypnopressure is more effective in lowering anxiety in patients undergoing a hemodialysis program.Keywords: anxiety, acupressure, hypnotherapy, hypnopressure, hemodialysisCorrespondence: Hanung Prasetya. Health Polytechnique of Health Ministry Surakarta. Jl. Letjend Sutoyo, Mojosongo, Surakarta 57127. Email: [email protected]. Mobile: 08122638908Indonesian Journal of Medicine (2023), 08(01): 59-67https://doi.org/10.26911/theijmed.2023.08.01.0
Effect of Cryotherapy Combined with William Flexion Exercise in Reducing Myogenic Low Back Pain
Get PDFBackground: Health problems related to daily activities can be experienced by individuals or groups. The most common complaint in the musculoskeletal system is low back pain. Low Back Pain according to the Ministry of Health of the Republic of Indonesia in 2018 means pain that is felt in the lower back area, between the lowest costal angle to the sacrum. The purpose of this study was to determine the effect of adding cold pack therapy to the William flexion exercise on reducing pain in myogenic LBP patients.
Subjects and Method: This was an experiment study conducted at Dr. Moewardi Hospital, Surakarta, Central Java, in September 2022. A sample of 22 patients with myogenic low back pain was allocated into two groups. The dependent variable was pain. The independent variable was cryotherapy combined with William flexion exercise. Pain was measured using quadripel visual analogue scale. Mean between groups after intervention was analyzed using independent t test.
Results: Mean of pain in the intervention group (Mean= 6.27; SD= 1.00) was lower than control group (Mean= 7.09; SD= 0.94), and it was statistically significant (p<0.001).
Conclusion: Cryotherapy combined with William flexion exercise is better to reduce pain in patients with myogenic low back pain.
Keywords: low back pain myogenic, cryotherapy, William flexion exercise.
Correspondence: Yoga Handita Windiastoni. Study Program of Physiotherapy, Health Polytechnic, Ministry of Health Surakarta, Karanganyar, Central Java. Email: [email protected]. Mobile: 081329036114.