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Sustainable groundwater treatment technologies for underserved rural communities in emerging economies
No full textWorldwide, about one out of two people depend on groundwater resources to satisfy their drinking water needs. While groundwater typically is of higher quality than surface water, pollution and geologic conditions may require treating groundwater to meet safe water quality criteria. Herein, a critical overview is presented of water treatment technologies for rural and underserved communities in emerging economies that depend on groundwater. Given that small to medium sized rural communities in emerging economies often lack the financial resources to support technologically complex and expensive centralized public water treatment systems, the focus is on proven technologies that are sustainable and acceptable by the rural population. After an overview of the underlying treatment mechanisms and the principal groundwater contaminants targeted by the traditional, advanced, and experimental water treatment technologies, we identify the groundwater quality parameters that may impact or interfere with the technology performance. We also introduce enabling environmental factors that might govern the implementation of water treatment technologies in the target communities and a brief discussion of safe storage of water after treatment to underline the importance of protecting the water from re-contamination. Our overview is further supported by tabulated summaries of the principal (dis)advantages of each technology covered herein, including cost considerations and social acceptance. Overall, our review suggests that underserved rural communities have sustainable and affordable options for cases where the quality of local groundwater resources requires treatment
Strengthening and Sustaining Dual Language Education in Catholic Schools
No full textThe purpose of this article is two-fold. First, we seek to make a case for the promise of dual language programs to enhance Catholic schooling and enrich educational opportunities for Latinx students. Second, we offer insights into the current landscape of Catholic schools with dual language programs, drawing upon data from a national survey conducted by University of Notre Dame researchers in 2020. Through our presentation of the findings, we consider characteristics of current program models and identify areas of success, challenges, and opportunities for future growth. We conclude with a discussion of the possibilities for strengthening and sustaining dual language education in Catholic schools
Coresidence increases the risk of testing positive for COVID-19 among older Brazilians
Get PDFBackground: Brazil is among the countries hit hardest by COVID-19, and older adults are among the vulnerable groups. Intergenerational coresidence and interdependence among family members, both prevalent in Brazil, likely increase social and physical contact and thus potential infection.
Methods: Using nationally representative data from the COVID-19 module of the Brazilian National Household Sample Survey (Pesquisa Nacional por Amostra de Domicílios), collected between July and November of 2020, we examined the association between living arrangements and exposure to and testing for COVID-19 among 63,816 Brazilians aged 60 years and older. We examine whether living arrangements influence self-reported COVID-19 symptoms as an indicator of subjective health assessment, testing as an indicator of health care service use, and a positive COVID-19 test result as an objective indicator of exposure to the disease.
Results: Living arrangements shape older adults’ vulnerabilities to COVID-19 exposure and testing. Specifically, those living alone were more likely to report having symptoms and having had a test for COVID-19. However, older adults in multigenerational and skipped generation households were more likely than solo-dwellers to test positive for COVID- 19. Those with symptoms were more likely to test, regardless of their living arrangement. Among older adults without symptoms, those living alone had a higher probability of testing than those living in multigenerational or skippedgeneration households.
Conclusions: Overall, our findings suggest that coresidence with younger family members puts older adults’ health at risk in the context of COVID-19. As younger Brazilians are increasingly vulnerable to COVID-19 and experiencing severe outcomes, policy makers need to be more attentive to the health needs of households that comprise older and younger cohorts, which are also more prevalent in poor and marginalized segments of the population
The Developing Brain: Considering the Multifactorial Effects of Obesity, Physical Activity & Mental Wellbeing in Childhood and Adolescence
Get PDFObesity during childhood has been associated with many important physiological and neurological health considerations. Specifically concerning are the associations between youth obesity and declines in mental health, as shown with increasing rates of adolescent depression and anxiety worldwide. The emergence of mental health disorders commonly arises during adolescent development, and approximately half the global population satisfy the criteria for at least one psychiatric disorder in their lifetime, suggesting a need for early intervention. Adolescence is critical time whereby brain structure and functions are not only negatively associated with obesity and declines in mental health, while also coinciding with significant declines in rates of physical activity among individuals in this age group. Physical activity is thus a prime candidate to address the intersection of obesity and mental health crises occurring globally. This review addresses the important considerations between physiological health (obesity, aerobic fitness, physical activity), brain health (structure and function), and mental wellbeing symptomology. Lastly, we pose a theoretical framework which asks important questions regarding the influence of physiological health on the association between brain health and the development of depression and anxiety symptoms in adolescence. Specifically, we hypothesize that obesity is a mediating risk factor on the associations between brain health and psychopathology, whereas physical activity is a mediating protective factor. We conclude with recommendations for promoting physical activity and reducing sedentary time
Identification of SARS-CoV-2 Main Protease Inhibitors from a Library of Minor Cannabinoids by Biochemical Inhibition Assay and Surface Plasmon Resonance Characterized Binding Affinity
Get PDFThe replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by its main protease (Mpro), which is a plausible therapeutic target for coronavirus disease 2019 (COVID-19). Although numerous in silico studies reported the potential inhibitory effects of natural products including cannabis and cannabinoids on SARS-CoV-2 Mpro, their anti-Mpro activities are not well validated by biological experimental data. Herein, a library of minor cannabinoids belonging to several chemotypes including tetrahydrocannabinols, cannabidiols, cannabigerols, cannabichromenes, cannabinodiols, cannabicyclols, cannabinols, and cannabitriols was evaluated for their anti-Mpro activity using a biochemical assay. Additionally, the binding affinities and molecular interactions between the active cannabinoids and the Mpro protein were studied by a biophysical technique (surface plasmon resonance; SPR) and molecular docking, respectively. Cannabinoids tetrahydrocannabutol and cannabigerolic acid were the most active Mpro inhibitors (IC50 = 3.62 and 14.40 μM, respectively) and cannabigerolic acid had a binding affinity KD=2.16×10−4 role= presentation \u3e����=2.16×10−4 M). A preliminary structure and activity relationship study revealed that the anti-Mpro role= presentation \u3eMpro effects of cannabinoids were influenced by the decarboxylation of cannabinoids and the length of cannabinoids’ alkyl side chain. Findings from the biochemical, biophysical, and computational assays support the growing evidence of cannabinoids’ inhibitory effects on SARS-CoV-2 Mpro
The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study
No full textGrowing evidence suggests that the glucagon-like peptide-1 (GLP-1) system modulates alcohol seeking and consumption, and GLP-1 analogues may represent novel pharmacotherapies for alcohol use disorder (AUD). Accordingly, it is important to understand the potential effects of alcohol on the endogenous GLP-1 system. In a series of secondary analyses of previous human laboratory experiments, we first examined the effects of alcohol administration, with different doses and routes of administration, on peripheral active GLP-1 concentrations in heavy-drinking individuals with AUD enrolled in placebo-controlled pharmacological studies (only placebo conditions were analysed here). Alcohol administration resulted in a significant reduction of GLP-1 levels across the four experiments (oral alcohol, variable dose: F3,28 = 6.52, p = 0.002; oral alcohol, fixed dose: F7,75.94 = 5.08, p \u3c 0.001; intravenous alcohol, variable dose: F4,37.03 = 20.72, p \u3c 0.001; intravenous alcohol, fixed dose: F4,13.92 = 10.44, p \u3c 0.001). Next, central expression of the GLP-1 receptor (GLP-1R) in post-mortem brain tissues (amygdala, ventral tegmental area, nucleus accumbens, hippocampus and prefrontal cortex) was compared between individuals with AUD and controls. Fold change of GLP-1R mRNA in the hippocampus was significantly higher in individuals with AUD, compared to controls (F1,21 = 6.80, p = 0.01). A trend-level effect with the same direction was also found in the prefrontal cortex (F1,20 = 3.07, p = 0.09). Exploratory analyses showed that GLP-1R gene expression levels were correlated with behavioural measures of alcohol drinking (hippocampus) and cigarette smoking (hippocampus and prefrontal cortex). Collectively, these data provide novel information on the crosstalk between alcohol and GLP-1 in a clinically relevant sample. Further studies are needed to understand the underlying mechanisms of this link
A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data
No full textGhrelin is a gastric-derived peptide hormone with demonstrated impact on alcohol intake and craving, but the reverse side of this bidirectional link, that is, the effects of alcohol on the ghrelin system, remains to be fully established. To further characterize this relationship, we examined (1) ghrelin levels via secondary analysis of human laboratory alcohol administration experiments with heavy-drinking participants; (2) expression of ghrelin, ghrelin receptor, and ghrelin-O-acyltransferase (GOAT) genes (GHRL, GHSR, and MBOAT4, respectively) in post-mortem brain tissue from individuals with alcohol use disorder (AUD) versus controls; (3) ghrelin levels in Ghsr knockout and wild-type rats following intraperitoneal (i.p.) alcohol administration; (4) effect of alcohol on ghrelin secretion from gastric mucosa cells ex vivo and GOAT enzymatic activity in vitro; and (5) ghrelin levels in rats following i.p. alcohol administration versus a calorically equivalent non-alcoholic sucrose solution. Acyl- and total-ghrelin levels decreased following acute alcohol administration in humans, but AUD was not associated with changes in central expression of ghrelin system genes in post-mortem tissue. In rats, alcohol decreased acyl-ghrelin, but not des-acyl-ghrelin, in both Ghsr knockout and wild-type rats. No dose-dependent effects of alcohol were observed on acyl-ghrelin secretion from gastric mucosa cells or on GOAT acylation activity. Lastly, alcohol and sucrose produced distinct effects on ghrelin in rats despite equivalent caloric value. Our findings suggest that alcohol acutely decreases peripheral ghrelin concentrations in vivo, but not in proportion to alcohol\u27s caloric value or through direct interaction with ghrelin-secreting gastric mucosal cells, the ghrelin receptor, or the GOAT enzyme
PFAS and Precursor Bioaccumulation in Freshwater Recreational Fish: Implications for Fish Advisories
Get PDFPer- and polyfluoroalkyl substances (PFAS) are a diverse class of fluorinated anthropogenic chemicals that include perfluoroalkyl acids (PFAA), which are widely used in modern commerce. Many products and environmental samples contain abundant precursors that can degrade into terminal PFAA associated with adverse health effects. Fish consumption is an important dietary exposure source for PFAS that bioaccumulate in food webs. However, little is known about bioaccumulation of PFAA precursors. Here, we identify and quantify PFAS in recreational fish species collected from surface waters across New Hampshire, US, using a toolbox of analytical methods. Targeted analysis of paired water and tissue samples suggests that many precursors below detection in water have a higher bioaccumulation potential than their terminal PFAA. Perfluorobutane sulfonamide (FBSA), a short-chain precursor produced by electrochemical fluorination, was detected in all fish samples analyzed for this compound. The total oxidizable precursor assay interpreted using Bayesian inference revealed fish muscle tissue contained additional, short-chain precursors in high concentration samples. Suspect screening analysis indicated these were perfluoroalkyl sulfonamide precursors with three and five perfluorinated carbons. Fish consumption advisories are primarily being developed for perfluorooctane sulfonate (PFOS), but this work reinforces the need for risk evaluations to consider additional bioaccumulative PFAS, including perfluoroalkyl sulfonamide precursors
Strength and consistency of density dependence in marine fish productivity
Get PDFThe correct prediction of the shape and strength of density dependence in productivity is key to predicting future stock development and providing the best possible long-term fisheries management advice. Here, we identify unbiased estimators of the relationship between somatic growth, recruitment and density, and apply these to 80 stocks in the Northeast Atlantic. The analyses revealed density-dependent recruitment in 68% of the stocks. Excluding pelagic stocks exhibiting significant trends in spawning stock biomass, the probability of significant density dependence was even higher at 78%. The relationships demonstrated that at the commonly used biomass limit of 0.2 times maximum spawning stock size, only 32% of the stocks attained three quarters of their maximum recruitment. This leaves 68% of the stocks with less than three quarters of their maximum recruitment at this biomass limit. Significantly lower recruitment at high stock size than at intermediate stock size was seen in 38% of the stocks. Density dependence in late growth occurred in 54% of the stocks, whereas early growth was generally density-independent. Pelagic stocks were less likely to exhibit density dependence in recruitment than demersal and benthic stocks. We recommend that both the degree to which productivity is related to density and the degree to which the relationship changes over time should be investigated. Both of these aspects should be considered in evaluations of whether sustainability and yield can be improved by including density dependence in forecasts of the effects of different management actions
Autonomous Wintertime Observations of Air-Sea Exchange in the Gulf Stream Reveal a Perfect Storm for Ocean CO2 Uptake
No full textA scarcity of wintertime observations of surface ocean carbon dioxide partial pressure (pCO2) in and near the Gulf Stream creates uncertainty in the magnitude of the regional carbon sink and its controlling mechanisms. Recent observations from an Uncrewed Surface Vehicle (USV), outfitted with a payload to measure surface ocean and lower atmosphere pCO2, revealed sharp gradients in ocean pCO2 across the Gulf Stream. Surface ocean pCO2 was lower by ∼50 μatm relative to the atmosphere in the subtropical mode water (STMW) formation region. This undersaturation combined with strong wintertime winds allowed for rapid ocean uptake of CO2, averaging −11.5 mmol m−2 day−1 during the February 2019 USV mission. The unique timing of this mission revealed active STMW formation. The USV proved to be a useful tool for CO2 flux quantification in the poorly observed, dynamic western boundary current environment