E-Journal UMSIDA (Universitas Muhammadiyah Sidoarjo)
Not a member yet
1909 research outputs found
Sort by
Antibacterial Efficacy of Myrtus communis Nanoemulsion Against Multidrug-Resistant, ESBL-Producing Pseudomonas aeruginosa and Its Association with β-Lactam Resistance Profiles
No full textGeneral Background: Pseudomonas aeruginosa is a major opportunistic pathogen responsible for severe hospital-acquired infections and is increasingly associated with multidrug resistance mediated by extended-spectrum and metallo-β-lactamases. Specific Background: The rapid dissemination of ESBL- and MBL-producing P. aeruginosa has compromised the efficacy of third-generation cephalosporins and carbapenems, creating an urgent need for alternative antimicrobial strategies. Knowledge Gap: Evidence remains limited regarding the effectiveness of phytochemical nanoemulsions against genetically characterized MDR P. aeruginosa isolates. Aims: This study evaluated the antibacterial activity of a Myrtus communis essential oil nanoemulsion against clinical ESBL-producing P. aeruginosa and examined its association with β-lactam resistance profiles. Results: Among 350 clinical samples, 40 P. aeruginosa isolates showed high resistance to cephalosporins and carbapenems, with prevalent VIM, IMP, CTX-M, and SHV genes. The formulated nanoemulsion exhibited a mean droplet size of 96.15 nm and demonstrated strong antibacterial activity, with a minimum inhibitory concentration of 0.07 mg/µL and a minimum bactericidal concentration of 0.2 mg/µL, effectively inhibiting most MDR isolates. Novelty: This study integrates molecular resistance profiling with nanoemulsion-based phytotherapy against MDR P. aeruginosa. Implications: Myrtle nanoemulsion represents a promising adjunct or alternative antimicrobial approach for managing life-threatening MDR infections, particularly in settings with limited therapeutic options.Highlight :
ESBL and MBL genes were highly prevalent in multidrug-resistant P. aeruginosa.
Myrtus communis nanoemulsion showed stable nanoscale properties.
Low MIC and MBC values confirmed strong antibacterial activity.
Keywords : Pseudomonas aeruginosa, Myrtus communis nanoemulsion, Antibiotic resistance, ESBL and MBL genes, Antibacterial activit
The Importance of Endolymphatic Administration of Drugs In The Treatment of Persistent Postoperative Peritoniti
No full textPersistent postoperative peritonitis remains a major challenge in abdominal surgery due to high rates of septic complications, antimicrobial resistance, and insufficient drug concentrations at the site of inflammation, making optimization of regional drug delivery clinically relevant. This study aims to evaluate the clinical and immunological effectiveness of endolymphatic drug administration in the comprehensive treatment of appendicular peritonitis. A retrospective and comparative clinical study was conducted on 66 patients with appendicular peritonitis treated in surgical departments of Tashkent city clinics, divided into a main group receiving endolymphatic therapy and a control group managed with conventional treatment. Clinical severity scores, biochemical parameters, intoxication indices, and immunological markers were analyzed using non-parametric statistical methods. The results demonstrate that endolymphatic drug administration achieved higher local therapeutic concentrations, significantly improved lymphocyte subpopulations, enhanced humoral immunity indicators, reduced endogenous intoxication, and accelerated recovery compared with standard therapy. Unlike prior studies that focused primarily on systemic antibiotic regimens, this research provides empirical evidence on the immunomodulatory and detoxifying advantages of targeted endolymphatic therapy in postoperative peritonitis. These findings contribute to the theoretical understanding of lymphatic system involvement in inflammatory control and support practical and policy-oriented implications for integrating endolymphatic drug administration into surgical infection management protocols to reduce complications and improve patient outcomes.Keywords : Endolymphatic antibiotic therapy, appendicular peritonitis, immunomodulation, lymphatic drug delivery, surgical sepsis prevention, postoperative complicationsHighlight :
Endolymphatic therapy increases total T-lymphocytes 1.41-fold and improves immunoglobulin levels significantly.
Neutrophil phagocytic activity rises 1.68-fold in treated patients versus minimal improvement in controls.
The intervention normalizes microcirculation and enhances lymph transport into bloodstream effectively
Exploiting Klebsiella pneumoniae Arginine Deiminase: Purification, Characterization, and Selective Anticancer Activity
No full textGeneral Background: Arginine deiminase (ADI) represents a promising therapeutic enzyme for treating arginine-auxotrophic cancers by catalyzing L-arginine conversion to citrulline and ammonia, exploiting the metabolic vulnerability of cancer cells deficient in arginosuccinate synthetase (ASS). Specific Background: Colorectal cancer, ranking second in mortality and third in global incidence, demonstrates heterogeneous arginine metabolism with certain tumor subtypes exhibiting impaired ASS expression, rendering them susceptible to arginine deprivation therapy. Knowledge Gap: Despite ADI's therapeutic potential, comprehensive characterization of Klebsiella pneumoniae-derived ADI and its selective cytotoxicity against colorectal cancer remains insufficiently explored. Aims: This study isolated, purified, and characterized ADI from clinically isolated K. pneumoniae strains and evaluated its selective anticancer activity against HCT-116 colorectal cancer cells versus NCM460 normal colon cells. Results: Isolate No. 5 demonstrated optimal ADI production (12 U/mg), achieving 11-fold purification through three-step chromatographic procedures yielding 32.9 U/mg specific activity with 40.9% recovery; optimal enzymatic performance occurred at pH 7 and 37°C, with Mn²⁺ and Fe³⁺ enhancing activity (120% and 105% respectively) while EDTA inhibited it (73%), confirming metalloenzyme properties; cytotoxicity assays revealed selective anticancer activity with IC₅₀ values of 390 µg/mL against HCT-116 cells and >800 µg/mL against NCM460 cells, demonstrating 2.3-fold selectivity. Novelty: This investigation provides the first comprehensive biochemical characterization of K. pneumoniae-derived ADI with demonstrated selective cytotoxicity parameters specifically targeting colorectal cancer. Implications: These findings establish K. pneumoniae ADI as a promising selective therapeutic candidate for colorectal cancer treatment, warranting further development including PEGylation strategies and combination therapy investigations.Keywords : Arginine Deiminase, Klebsiella Pneumoniae, Enzyme Purification, Colorectal Cancer, CytotoxicityHighlight :
Enzyme achieved 11-fold purification yielding 32.9 U/mg through three-step protocol.
Optimal activity occurred at pH 7 and 37°C with metalloenzyme characteristics.
HCT-116 cancer cells showed 2.3-fold greater sensitivity than normal colon cells
Multimedia and Interactive Tools Foster Engagement in English as a Foreign Language Critical Reading
No full textGeneral Background: In English as a Foreign Language (EFL) education, critical reading is a core competency for developing higher-order thinking, yet many classrooms, particularly in East Kalimantan, still rely on outdated, passive methods. Specific Background: While multimedia and interactive tools offer potential for enhancing engagement, their integration into EFL critical reading remains inconsistent and often misaligned with learning goals. Knowledge Gap: Limited empirical studies apply the Triple E Framework—Engage, Enhance, Extend—in under-resourced, culturally diverse, and large EFL classrooms to specifically foster critical reading skills. Aims: This study investigates how multimedia and interactive tools, guided by the Triple E Framework, influence engagement, comprehension, and motivation in EFL critical reading. Results: Using a mixed-methods approach with 32 students, findings show that over half of the observed lecturers achieved an “exceptional connection” between learning goals and technology use, leading to improved focus, comprehension, and extended learning beyond class. Novelty: This research offers empirical validation of the Triple E Framework in large, diverse EFL contexts, linking teacher digital literacy to effective critical reading instruction. Implications: Results highlight the need for targeted professional development to equip educators with the skills to integrate technology purposefully, ultimately enhancing students’ readiness for academic and global communication.
Highlights:
Empirical validation of Triple E Framework in large, diverse EFL classrooms.
Teacher digital literacy as a key factor for effective technology integration.
Multimedia tools boost engagement, comprehension, and learning extension.
Keywords: Triple E Framework, EFL, Critical Reading, Multimedia Tools, Student Engagemen
Implementing Regional Inclusive Education Policies to Realize Education Without Borders: Implementasi Kebijakan Pendidikan Inklusif di Daerah untuk Mewujudkan Pendidikan Tanpa Batas
No full textInclusive education serves as a cornerstone in promoting equitable learning opportunities for all, especially for Children with Special Needs (ABK). In Gresik Regency, the implementation of Regent Regulation No. 42/2013 reflects a local commitment to this ideal. However, despite formal policies, significant challenges persist. A lack of teacher training, inadequate infrastructure, and entrenched social stigma continue to obstruct meaningful inclusion. Existing studies have yet to comprehensively explore the interplay between these constraints and the policy’s intended outcomes, exposing a critical knowledge gap. This study aims to analyze the challenges and opportunities inherent in implementing inclusive education in Gresik and evaluate the effectiveness of support programs. Using a qualitative literature review approach, the findings reveal that while barriers are significant, notable opportunities exist through the empowerment of Special Guidance Teachers (GPK), enhanced training, strong policy backing, and multisectoral collaboration. The novelty lies in the synthesis of policy analysis with community and educational dynamics to propose an integrated strategic framework. The implications underscore the necessity of strengthening educator capacity, infrastructure, and social attitudes to achieve inclusive education goals—providing a foundation for developing future policies and localized best practices.
Highlights:
Highlights policy gaps and challenges in inclusive education.
Emphasizes the role of Special Guidance Teachers (GPK).
Proposes strategic collaboration for better policy outcomes.
Keywords: Inclusive Education, Regional Policy, Special Needs Children, Educational Equity
 
Good Corporate Governance, Leverage, and Risk Management in Financial Performance Analysis: Tata Kelola Perusahaan yang Baik, Leverage, dan Manajemen Risiko dalam Analisis Kinerja Keuangan
No full textGeneral Background: Corporate financial performance is intricately linked with governance structures and financial strategies. Specific Background: In Indonesia’s mining sector, understanding how Good Corporate Governance (GCG) and Leverage influence performance through risk management remains underexplored. Knowledge Gap: Prior studies lack clarity on whether GCG and Leverage directly or indirectly impact financial outcomes via risk mitigation. Aim: This study investigates the effects of GCG components (institutional ownership, independent board of commissioners, audit committee) and Leverage (debt-to-equity ratio) on Return on Assets (ROA), incorporating risk management as an intermediary variable. Results: Utilizing SPSS 25 for descriptive analysis, classical assumption tests, and path analysis across 27 IDX-listed mining companies from 2019–2023, the results show that no independent variable significantly affects ROA collectively. However, the independent board of commissioners significantly influences risk management, which itself has no subsequent impact on financial performance. Novelty: This study highlights the limited mediating role of risk management, challenging assumptions about its integrative influence on financial outcomes. Implications: The findings enrich corporate finance theory and suggest organizations must realign risk governance frameworks to enhance budget execution and capitalize on strategic opportunities.
Highlights:
Reveals limited impact of GCG and Leverage on ROA.
Highlights the significant role of independent commissioners in risk management.
Challenges the assumption that risk management boosts financial performance.
Keywords : Good Corporate Governance, Leverage, Financial Performance, Risk Management, Path Analysi
Digital Leadership Advancing Teacher Performance in Junior High Schools: Kepemimpinan Digital Memajukan Kinerja Guru di Sekolah Menengah Pertama
No full textGeneral Background: Digital transformation in education necessitates adaptive leadership to optimize institutional performance. Specific Background: In the context of SMPN 1 Gedangan and SMPN 1 Porong, the role of principals as digital leaders remains underexplored, particularly in influencing teacher performance.Knowledge Gap: Prior studies often overlook the qualitative implications of digital leadership in middle schools with evolving technological infrastructure. Aims: This study investigates the impact of school principals' digital leadership—including digitized systems, innovation programs, and collaboration—on enhancing teacher performance. Methods: Using a qualitative approach, data were gathered through in-depth interviews and observations, analyzed descriptively, and validated via Focus Group Discussions (FGD) and data triangulation. Results: Findings reveal that digital leadership significantly improves teacher capabilities, as evidenced by improvements in PMM E-performance reports, attendance tracking, training participation, digital program initiatives, and principal supervision. Novelty: This study provides practical, observation-based insights on how digital leadership directly correlates with measurable performance indicators at the school level. Implications: The study offers actionable implications for educational leadership, emphasizing synergy between principals and staff in advancing digital transformation within public junior high schools.
Highlights:
Highlights the role of digital leadership in enhancing teacher effectiveness.
Emphasizes qualitative methods using FGD and triangulation for data validation.
Shows measurable outcomes through E-performance and school innovation metrics.
Keywords: Digital Leadership, Teacher Performance, Educational Innovation, School Management 
Strategic Marketing Approach and Innovation in Sam Antep Gilam Carpet Company
No full textGeneral Background: The global carpet industry continues to evolve amid rising consumer expectations for quality, sustainability, and innovation. Specific Background: SAG Carpet Company, a market leader in Uzbekistan, integrates traditional craftsmanship with modern production to offer high-quality carpets, artificial grass, and agricultural exports. Knowledge Gap: Despite its market presence, limited studies analyze how such heritage-based firms adopt strategic marketing frameworks in competitive international contexts. Aims: This study aims to evaluate SAG's comprehensive marketing strategy using SWOT, BCG Matrix, Marketing Mix (4Ps), and its dual-market (B2B and B2C) approach. Results: The analysis reveals that SAG's strengths lie in its vertically integrated production, diversified portfolio, and expanding global footprint. However, it faces challenges from increasing competition and shifting consumer trends. Novelty: This paper contributes by aligning traditional manufacturing values with digital transformation strategies, including smart carpet innovation, augmented reality retailing, and value-based pricing. Implications: The findings highlight strategic pathways for similar firms to sustain competitiveness by balancing cultural authenticity with technological advancement, offering insights for practitioners in emerging economies seeking global market integration.
Highlights:
Highlights SAG's integration of tradition and innovation in global marketing.
Emphasizes strategic use of 4Ps and segmentation for market expansion.
Recommends digital transformation to sustain competitive advantage.
Keywords: Marketing Strategy, SAG Carpet Company, SWOT Analysis, BCG Matrix, Value-Based Pricin
Optimization of Barrel Vault Space Frame Model for Earthquake Resistant Structure: Optimasi Model Rangka Ruang Barrel Vault untuk Struktur Tahan Gempa
No full textGeneral Background: Long-span buildings are essential in accommodating wide, unobstructed interior spaces, commonly applied in structures such as stadiums and assembly halls. Specific Background: One effective structural system for such buildings is the space truss with barrel vault configurations, known for their strength and spatial efficiency. Knowledge Gap: However, limited comparative studies exist on the seismic performance and material efficiency of various barrel vault space truss models. Aims: This study aims to analyze and optimize seven barrel vault space truss models spanning 192 m by 120 m with a height of 50 m, focusing on earthquake load response and structural tonnage. Results: The analysis reveals that model 1 has the lowest base shear (V = 3142.50 kN) and structural tonnage, while model 6 exhibits the highest tonnage—62.24% heavier than model 1—and base shear of 4881.18 kN. Novelty: The study provides a comparative seismic performance assessment of large-span space truss models under identical geometric and loading conditions. Implications: These findings support the structural optimization of space trusses for earthquake-prone regions, offering practical insights for efficient and resilient long-span building design.
Highlights:
Highlights the efficiency of barrel vault space trusses in seismic conditions.
Compares seven models to determine the most optimal structure.
Emphasizes material savings through structural optimization.
Keywords: Space Truss, Earthquake Load, Structural Analysis, Barrel Vault, Optimization
 
Green Synthesis of ZnO Nanoparticles Using Diverse Plant Extracts: Sintesis Hijau Nanopartikel ZnO Menggunakan Ekstrak Tumbuhan yang Beragam
No full textGeneral background: Nanotechnology has emerged as a vital field for the development of functional materials at the nanoscale, with zinc oxide nanoparticles (ZnO NPs) gaining attention due to their high thermal stability, cost-efficiency, and antimicrobial properties. Specific background: Traditional physical and chemical synthesis methods, while effective, often pose environmental risks and scalability challenges. In contrast, green synthesis utilizing plant extracts offers a sustainable alternative. Knowledge gap: Despite growing interest, a comprehensive understanding of how different plant species and zinc salts affect ZnO NP morphology and functionality remains limited. Aims: This review aims to consolidate recent studies on the green synthesis of ZnO NPs using diverse plant extracts and zinc precursors, focusing on synthesis parameters and resulting nanoparticle characteristics. Results: Analysis reveals that variables such as molarity, temperature, and reaction time significantly influence particle size (8–66 nm), shape (spherical, hexagonal, rod-like), and bioactivity (antibacterial, anticancer, antioxidant). Novelty: This work systematically compares a wide array of plant-mediated synthesis strategies, offering a unique reference for optimizing ZnO NP production. Implications: These findings highlight the potential of eco-friendly synthesis routes for biomedical, environmental, and industrial applications, supporting further advancement in sustainable nanotechnology.Highlight :
The review emphasizes the eco-friendly and cost-effective green synthesis of ZnO nanoparticles using various plant extracts.
It discusses how synthesis conditions (e.g., temperature, molarity, reaction time) significantly affect size and morphology of ZnO NPs.
Biosynthesized ZnO NPs exhibit diverse biomedical and environmental applications, including antimicrobial, anticancer, and photocatalytic uses.
Keywords : Nanotechnology, Green Synthesis, ZnO Nanoparticles, Plant Extracts, Biomedical Applications