Gif University: Repository / 岐阜薬大学術リポジトリ
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Glutamatergic dysfunction is associated with phenotypes of VGF-overexpressing mice
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Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model
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Electrochemical and Computational Analysis of Superoxide/Hydroperoxyl Radical Trap by 5,5-Dimethyl-1-pyrroline N-oxide in N,N-dimethylformamide
No full textSpin trap of electrogenerated superoxide radical anion (O2•−) and hydroperoxyl radical (HO2•)
using 5,5-dimethyl-1-pyrroline N-oxide (DMPO) was investigated via cyclicvoltammetry and in
situ electrolytic electron spin resonance (ESR) measurements in dehydrated N,Ndimethylformamide (DMF) aided by density functional theory calculations. In aprotic environments, DMPO gradually traps the electrogenerated O2•, however, its trap rate is considerably slow. Conversely, adding a small amount of proton source to O2•− to form HO2• changes the voltammetric behavior, rendering the detection of the spin adduct easy with ESR.
These electrochemical and ESR results obtained in aprotic DMF well demonstrate the differences between O2•− trap and HO2• trap, since the effects of a proton derived from aqueous
solvent on O2•−/HO2• traps, such as superoxide spontaneous dismutation and pH of solution, are not involved. Accordingly, the obtained kinetic and thermodynamic results show the exact
chemical reaction parameters for each of the O2•−/HO2• trap. Therefore, these results will be
useful for estimating an apparent O2•−/HO2• adduct-formation in aqueous ESR measurements.articl
Reactivities of Hydroxycinnamic Acid Derivatives Involving Caffeic Acid toward Electrogenerated Superoxide in N,N-Dimethylformamide
Get PDFReactivity of (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid (caffeic acid), classified as a hydroxycinnamic acid (HCA) derivative, toward electrogenerated superoxide radical anion (O2•−) was investigated through cyclic voltammetry, in situ electrolytic electron spin resonance spectrometry, and in situ electrolytic ultraviolet–visible spectrometry in N,N-dimethylformamide (DMF), aided by density functional theory (DFT) calculations. The quasi-reversible redox of dioxygen/O2•− is modified in the presence of caffeic acid, suggesting that O2•− is scavenged by caffeic acid through proton-coupled electron transfer. The reactivities of caffeic acid toward O2•− are mediated by the ortho-diphenol (catechol) moiety rather than by the acryloyl group, as experimentally confirmed in comparative analyses with other HCAs. The electrochemical and DFT results in DMF suggested that a concerted two-proton-coupled electron transfer mechanism proceeds via the catechol moiety. This mechanism embodies the superior kinetics of O2•− scavenging by caffeic acid.articl
Cost-effectiveness analysis of olanzapine in four-drug antiemetic therapy in Japanese patients treated with highly emetogenic cisplatin-containing chemotherapy
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Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis
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Electrochemical and Computational Analysis of Superoxide/Hydroperoxyl Radical Trap by 5,5-Dimethyl-1-pyrroline N-oxide in N,N- dimethylformamide
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