Gif University: Repository / 岐阜薬大学術リポジトリ
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NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells
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Development of a Lateral Flow Assay for Bevacizumab Using an Anti-Idiotype DNA Aptamer as a Capture Molecule
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Reactivities of 1,2-, 1,3-, and 1,4-dihydroxynaphthalenes toward electrogenerated superoxide in N,N-dimethylformamide through proton-coupled electron transfer
No full textWe have carried out an electrochemical and theoretical study on the reactivity of 1,2-, 1,3-, and 1,4-dihydroxynaphthalenes (1nH2NQ, n = 2, 3, 4) toward electrogenerated superoxide radical anion (O2•−) in N,N-dimethylformamide. Cyclicvoltammetry and in situ electrolytic electron spin resonance measurements revealed that the quinone–hydroquinone π-conjugation plays an important role in a successful O2•− scavenging by 12H2NQ and 14H2NQ through proton-coupled electron transfer (PCET) reaction. The reactivities of 12H2NQ and 14H2NQ toward O2•− were mediated by the ortho- (catechol) or para-diphenol (hydroquinone) moieties, as experimentally confirmed in comparative analyses with catechol, hydroquinone, and 13H2NQ, aided by density functional theory (DFT) calculations. The electrochemical and DFT results suggested that a concerted PCET mechanism involving two-proton transfers and one-electron transfer proceeds, demonstrating a successful O2•− scavenging by 12H2NQ and 14H2NQ. Furthermore, a subsequent electron transfer between molecular dioxygen and product-naphthoquinone-radicals was observed, where O2•− was regenerated. The DFT analysis suggested that the spin distribution on the planar naphthalene ring embodies the superior kinetics of the PCET and the subsequent generation of O2•− from dioxygen demonstrated in the electrochemical results.articl
Apoptotic mechanism in human brain microvascular endothelial cells triggered by 4′-iodo-α-pyrrolidinononanophenone: Contribution of decrease in antioxidant properties
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Development of cisplatin resistance in breast cancer MCF7 cells by up-regulating aldo-keto reductase 1C3 expression, glutathione synthesis and proteasomal proteolysis
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