Gif University: Repository / 岐阜薬大学術リポジトリ
Not a member yet
5618 research outputs found
Sort by
Investigation into the usefulness of cynomolgus monkeys with spontaneously elevated intraocular pressure as a model for glaucoma treatment research
No full textjournal articl
Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect
No full textjournal articl
Granulation of ibuprofen/isonicotinamide co-crystals by continuous spray granulator (CTS-SGR)
No full textjournal articl
Late-stage diversification strategy for synthesizing ynamides through copper-catalyzed diynylation and azide–alkyne cycloaddition
No full textjournal articl
Novel, highly sensitive, in vivo screening method detects estrogenic activity at low doses of bisphenol A.
No full textjournal articl
Reactivity of trans-Resveratrol toward Electrogenerated Superoxide in N,N-Dimethylformamide
No full textThe reactivity of 5-[(E)-2-(4-hydroxyphenyl)ethen-1-yl]benzene-1,3-diol (trans-resveratrol) and related compounds toward electrogenerated superoxide radical anion (O2•–) were investigated using electrochemistry, in situ electrolytic electron spin resonance, and in situ electrolytic ultraviolet–visible spectral measurements, in N,N-dimethylformamide (DMF) with the aid of density functional theory (DFT) calculations. The quasi-reversible cyclic voltammogram of dioxygen/O2•– was modified by the presence of trans-resveratrol, suggesting that the electrogenerated O2•– was scavenged by trans-resveratrol through proton-coupled electron transfer (PCET) via three phenolic hydroxy groups (OH) on the stilbene moiety. The reactivity of trans-resveratrol toward O2•– characterized by the OHs was experimentally confirmed in comparative analyses using some related compounds, pinosylvin, pterostilbene, p-coumaric acid, and so on, in DMF. The electrochemical and DFT results suggested that a concerted PCET mechanism via 4′OH of trans-resveratrol proceeds, where the coplanarity of the two phenolic rings in the stilbene moiety linked by an ethylene bridge is essential for a successful O2•– scavenging.articl
