International Journal of Advances in Medical Biotechnology (IJAMB)
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Bioinorganic applications of gold and platinum coordination compounds: a brief historical overview and recent advances in 2017
Get PDFoai:ojs.journalamb.com:article/5Gold-based metallodrugs have been used for a wide variety of medical–related applications. Although none of them have reached clinical trials, many compounds show potential for a plethora of possible applications. Platinum compounds, on the other hand, are the leading class of metallodrugs used for the treatment of cancer, with successful representatives worldwide, such as cisplatin, carboplatin and oxaliplatin. In this minireview, we will briefly present the development of metallodrugs based on such metals throughout the year of 2017
From nano to macro: Enabling Nanotechnologies for Human Organ Biofabrication (Electrospun Nanofibers and Hybrid Technique)
Get PDFThis review proposes to present how materials at nanolevel scale can contribute to the development of three-dimensional (3D) structures, human tissues, and organs which have macrolevel organization. Specific nanomaterials such as nanofibers and nanoparticles are presented and discussed in their application for biofabricating 3D human tissues and organs. The concept of self-assembling magnetic tissue spheroids as an intermediate mesolevel structure between nano and macrolevel organization and building blocks for biofabrication in dual scale level of complex 3D human tissues and organs is detached. The challenges and perspectives of employing nanomaterials and nanotechnological strategies in the biofabrication were also traced
Bacterial cellulose-based hydrogel for wound healing: characterization and in vitro evaluation
Get PDFBacterial cellulose (BC) has been considered a promising biopolymer with applications in several areas of knowledge, including medicine, mainly due to its ability to assist in the treatment of dermal lesions. Many groups and companies have been making efforts to develop new BC-based materials in order to add new characteristics and therapeutic possibilities. Recently, Seven Indústria de Produtos Biotecnológicos Ltda company developed a BC-based hydrogel aiming to verify the interaction among the formulation components, its potential for wound healing and biocompatibility studies. BC-based hydrogel was characterized and compared with pristine BC film. Physicochemical characterization includes rheological measurements, thermal analyses, field emission gun - scanning electron microscopy (FE-SEM) and in vitro cell migration. BC-based hydrogel showed adequate interaction among the components of the formulation, which may positively influence its stability. In addition, the BC-based hydrogel accelerated the healing processes demonstrating its potential in dermal lesion treatment
Recent advances of synthesis of Boron derivatives and their applications in bioimaging
Get PDFThe increasing interest in the luminescent boron materials is due to their potential application in diverse areas such as solar cells, optoelectronic devices, and biological imaging materials. Continuous search for the compounds with better properties, luminescent organoboron materials have been gaining more importance, especially in the development of new technologies and novel techniques for bioimaging, which is a powerful tool to analyze the cellular organelles with important value into the cell biology and medical research. Synthesis, properties, and applications of luminescent boron compounds and their application in bioimaging are reviewed.
New insights into bacterial cellulose materials: production and modification strategies
Get PDFKomagataeibacter xylinus cultures produced high amount of bacterial cellulose (BC), which has a structure of nanoporous network of interlaced fibers. When the culture is performed under static experimental conditions, a membrane with characteristics of highly hydrated hydrogel and good mechanical properties is obtained with promissory applications in the biomedical field. Bacterial cellulose films can be used from dermal dressing and even as a controlled drug release system. Besides, stirred cultures of K. xylinus produced amorphous cellulose structures dispersed in the medium with physical and mechanical characteristics different from the membrane. In addition, new properties of BC can be obtained or added if the hydrogel is mixed with other compounds or modified post-purification using both organic and inorganic compounds.
Immobilization of biomolecules on natural clay minerals for medical applications
Get PDFBiomolecules are a group of organic entities that are important in many areas of research on nanomaterials and for biomedical and pharmaceutical applications. Advanced systems have been developed to attempt to protect the activity of biomolecules from rapid degradation and instability. Among these techniques, the incorporation or immobilization of biomolecules has become popular in the development of biocomposites. As such, clay minerals appear to be promising materials; combining a nanometer-scale size with their adsorptive capacity, lack of toxicity, and biocompatibility would result in enhanced biomaterial properties. This mini?review discusses the recent advances concerning biological molecules immobilized on clay minerals and their biomedical applications as biosensors, in regenerative medicine, and even as controlled delivery systems
Incorporation of micro/nanoparticles of Polycaprolactone with essential oil of Cymbopogon nardus in bacterial cellulose: Bacterial cellulose; Cymbopogon nardus; Nanoprecipitation Particles
No full textIncorporation studies of particles in different substrates with herbal assets growing. The objective of this work was the preparation and characterization of micro/nanoparticles containing Cymbopogon nardus essential oil; and the incorporation of them on bacterial cellulose. For the development of the membranes was used the static culture medium and for the preparation of micro/nanoparticles was used the nanoprecipitation methodology. The incorporation of micro/nanoparticles was performed on samples of bacterial cellulose in wet and dry form. For the characterization of micro/nanoparticles were carried out analysis of SEM, zeta potential and particle size. For the verification of the incorporation of particulate matter in cellulose, analyses were conducted of SEM and FTIR. The results showed that it is possible the production and incorporation of micro/nanoparticles containing essential oil in bacterial cellulose membranes in wet form with ethanol
II International Symposium of Medicinal Chemistry and Regenerative Medicine
Get PDFThe II International Symposium on Medicinal Chemistry and Regenerative Medicine, held from November 22nd to 24th at, this event was directed to undergraduate and graduate students, professionals from the medical, pharmaceutical, biotechnology innovation management and entrepreneurs, as well as researchers involved in the areas of Medicinal Chemistry, Regenerative Medicine and Biotechnology.The event aimed to promote the dissemination of new research and innovations that are at the frontier of knowledge in the area of Regenerative Medicine and Medicinal Chemistry and also to promote interaction with companies interested in these researches. Thus, as a result of the event, it is hoped to encourage discussion, sharing of knowledge, articulation of partnerships for new research projects and also generate a spark of ideas that can be led by future entrepreneurs.In this second edition, a scientific session was held with the presentation of posters. The abstracts submitted and approved by the scientific committee are below.Central themes? Biopolymers? Medicinal Chemistry? Regenerative Medicine? Innovation Management on Biotechnolog
Intelligent copolymers based on poly (N-isopropylacrylamide) PNIPAm with potential use in biomedical applications. Part i: PNIPAm functionalization with 3-butenoic acid and piperazine
Get PDFThe synthesis and characterization of the thermosensitive copolymers based on Poly (N-Isopropylacrylamide) (PNIPAm) and 3-butenoic acid and functionalized with piperazine was carried out. The free radical polymerization of the PNIPA copolymer with 3-butenoic acid was performed under microwave radiation. After obtaining this copolymer, the carboxyl groups present in the copolymer chain were activated with 1-ethyl- (3-3-dimethylaminopropyl) carbodiimide in the presence of N-hydroxysuccinimide, improving its reactivity to incorporate the piperazine through its amino group. The characterization consisted: differential scanning calorimetric and ultraviolet-visible spectrophotometry to determine the LCST phase transition temperature, ranging from (30-35)°C. Structurally it was analyzed by infrared spectroscopy. A morphological analysis was performed using scanning electron microscopy, after simulating an injectable process, with the objective to observe internally the porosity and interconnectivity. The biocompatibility was evaluated through hemocompatibility tests and it was observed that the copolymers obtained were not cytotoxic. In base of the results, the chemical structure of these new copolymers confers a functionality that allows them to serve as nuclei to graft other molecules, such as polysaccharides. Then, the results obtained on the LCST temperature, porosity, interconnected pore network morphology, the ability to be injectable and the biocompatible nature of these copolymers are indicative that these new synthetic biomaterials have the potential to be used in biomedical, pharmacological and for tissue engineering. Also, once their biocompatibility was demonstrate, they may serve to generate interesting compounds having chemical anchor points for the possible addition of polysaccharides using insertion reactions, thereby generating graft copolymers with potential use in biomedical applications
Bacterial cellulose: Application as drug delivery system
Get PDFBacterial cellulose (BC) is a very interesting biopolymers to biomedical application, including drug delivery system, due to unique characteristics as such as high degree purity and of porosity, relative high permeability to liquid and gases, high holding water capacity, tensile strength and randomly oriented three-dimensional fiber network. Several authors described the use of BC membranes or copolymers to use as drug delivery system. The aim of the present mini-review was to show the wide and vantages application of the BC and its copolymers for use as controlled drug delivery system