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The Potential of the Eat, Sleep, Console Method in the Neonatal Intensive Care Unit: An Integrative Research Review (IRR)
No full texthttps://digitalcommons.providence.org/covenant_nurses_week_2025/1019/thumbnail.jp
Exploring the Intersection of Artificial Intelligence and Psychosocial Oncology: Enhancing Care in the Digital Age
No full textThis narrative review explores the transformative potential of generative artificial intelligence (AI) in psychosocial oncology, a field dedicated to addressing the emotional, psychological, social, and spiritual needs of individuals affected by cancer. AI-driven technologies, such as automated distress screening, chatbot interventions, and hybrid AI-human care models, offer unprecedented opportunities to enhance efficiency, improve access, and deliver personalized support. These innovations can significantly alleviate resource constraints and improve patient outcomes by addressing the multifaceted challenges of cancer care. At the same time, the review underscores the irreplaceable value of human interaction in providing empathy, navigating sensitive conversations, and addressing nuanced patient concerns. Ethical considerations, including patient comfort, privacy, and bias mitigation, remain critical to ensuring that AI aligns with patient-centered care principles. This article highlights the importance of collaboration among AI developers, clinicians, ethicists, and patients to design ethical, compassionate, and innovative AI solutions. By balancing technological advancements with human expertise, psychosocial oncology can achieve its ultimate goal: empowering patients and improving quality of life
Sentient Intelligence to Rescue Healthcare? Reflections on the Commercial Side of Healthcare.
No full textPopulation-Level Risk Factors for Kidney Outcomes in IgA Nephropathy: The CURE-CKD Registry.
No full textRATIONALE & OBJECTIVE: Although IgA nephropathy (IgAN) therapies are advancing quickly, therapeutic interventions are hampered by a lack of kidney disease identification and risk assessment. The study aim was to use population-level data from health systems to identify IgAN and assess risks.
STUDY DESIGN: A longitudinal and real-world cohort study.
SETTING & PARTICIPANTS: Electronic health record data for patients ≥18 years old with IgAN at Providence and University of California Los Angeles health systems during 2016-2022.
PREDICTORS: Health insurance and care utilization along with age, gender, race, ethnicity, estimated glomerular filtration rate (eGFR), urine albumin/creatinine ratio (UACR) or urine protein/creatinine ratio (UPCR), diabetes, hypertension, and medications.
OUTCOMES: Time to first major adverse kidney event (MAKE): ≥40% eGFR decline; eGFR \u3c 15 mL/min/1.73 m2; administrative codes for kidney failure, dialysis, or transplant; and death.
ANALYTICAL APPROACH: Kaplan-Meier survival curves and Cox proportional hazards models.
RESULTS: Patients with IgAN (n = 2,571) were 50% (n = 1,277) women and 58 ± 18 (mean ± SD) years old. At baseline, eGFR was 78 ± 27 mL/min/1.73 m
LIMITATIONS: Missingness, miscoding, and retrospective data.
CONCLUSIONS: Substantial loss of kidney function, kidney failure, and death were common events over a short period of time in patients with IgAN. Within health system populations, noncommercial health insurance and greater care utilization augmented risk prediction and could help to identify those who may benefit from closer monitoring and implementation of therapeutic interventions
The relationship between sleep and academic performance among multiple health care training programs.
No full textBACKGROUND: Sleep is linked with better academic performance in pharmacy and optometry students. No study was found that compared sleep and academic performance among students of different health care professions, nor any studies evaluating physician assistant students.
OBJECTIVE: To evaluate the relationship between sleep quality and quantity on memory retention and academic performance among students in health care professions.
METHODS: Marshall B. Ketchum University (MBKU) offers programs for Doctor of Pharmacy (PharmD), Doctor of Optometry (OD), and Master\u27s in Physician Assistant Studies (PA). Students filled out a cross-sectional survey about quality of sleep, quantity of sleep, and quantity of caffeine consumed, which were compared with GPA and memory retention. GPA was self-reported. Memory retention was assessed using quiz-style questions drawn from mandatory first-year coursework in ethics and public health.
RESULTS: The sample (N = 108) consisted of 50 OD students, 46 PharmD students, and 12 PA students. Memory retention negatively correlated with caffeine consumption during a typical weekday and during a typical weekend. Students who slept more the night before participating in this study earned higher scores on the memory retention task, regardless of how many years ago they took these classes. Drinking more caffeine during the weekends was correlated with lower GPA.
CONCLUSION: Because students who slept more on the night before taking the study demonstrated superior memory retention, we recommend that students obtain adequate sleep before an examination. Weaknesses of the study include possible bias or inaccuracy in self-reported data, and the retrospective design cannot demonstrate causation
Correction: Safety and Efficacy of Bimekizumab in Patients with Psoriatic Arthritis: 2-Year Results from Two Phase 3 Studies.
No full textMalnutrition in spondylodiscitis: an overlooked risk factor.
No full textOBJECTIVE: Spondylodiscitis presents a significant diagnostic and treatment challenge to healthcare providers, with various risk factors and treatment outcomes having been identified. Malnutrition, a multifactorial condition defined by imbalance or deficiency of nutrients, is a known risk factor for various adverse events such as postoperative infection and readmissions in spine surgery. However, its impact in SD has not yet been explored. The study aims to assess the prevalence of malnutrition and hypoalbuminemia in SD patients and their impact on the 90-day-all-cause readmission and in-hospital mortality rates.
METHODS: Using the 2020 Nationwide Readmission Database, adult patients were selected by primary ICD-10 diagnosis for SD (M46.2x, M46.3x and M46.4x). Demographic information and clinical data were extracted. Readmissions were identified by VisitLink. Patients were categorized into 2 groups: those with malnutrition and/or hypoalbuminemia and those without. Descriptive and comparative analysis, with multivariate regression models to assess for independent risk factors of mortality and readmission were performed.
METHODS: Using the 2020 Nationwide Readmission Database, adult patients were selected by primary ICD-10 diagnosis for SD (M46.2x, M46.3x and M46.4x). Demographic information and clinical data were extracted. Readmissions were identified by VisitLink. Patients were categorized into 2 groups: those with malnutrition and/or hypoalbuminemia and those without. Descriptive and comparative analysis, with multivariate regression models to assess for independent risk factors of mortality and readmission were performed.
CONCLUSION: Malnutrition and hypoalbuminemia are relatively common in SD patients and are significant risk factors for both in-hospital mortality and readmission. Early identification, including screening for hypoalbuminemia and management of malnutrition, may be beneficial in SD treatment
Janus-kinase inhibitor use in immune-mediated inflammatory diseases beyond licensed indications: A scoping review.
No full textINTRODUCTION: The use of Janus kinase inhibitors (JAKis) in immune-mediated inflammatory diseases (IMIDs) beyond licence is expanding rapidly. The aim of this scoping review was to identify and present the available evidence on the efficacy of JAKis in all conditions without marketing authorisation.
METHODS: Through a systematic literature search we identified studies including 5 or more patients that assessed the use of any JAKi for any efficacy outcome. Quantitative analyses in the form of pairwise meta-analyses were performed for eligible data from randomised controlled trials (RCTs) only.
RESULTS: Eighty-three (n = 83) studies in total were included in our review, assessing efficacy of JAKis in 34 IMIDs. In most conditions, JAKis exhibited generally positive effects, though the majority of evidence came from observational, non-comparative studies. Pairwise meta-analyses were possible for hidradenitis suppurativa and systemic lupus erythematosus (SLE). For hidradenitis suppurativa, we found a clear benefit of treatment with JAKis compared with placebo in achieving clinical response [OR 2.35, 95 % CI (1.24 to 4.46)]. For treatment-resistant SLE, the results were equivocal; JAKi showed some benefit over placebo but statistical significance was only reached for one of the two meta-analysed outcome measures [SLE Responder Index 4, OR 1.41, 95 % CI (1.01 to 1.98); SLE Disease Activity Index 2000; OR 1.36, 95 % CI (0.99 to 1.88)].
CONCLUSIONS: There is a rapidly increasing use of JAKis beyond current licencing in most IMIDs. Large comparative trials are necessary to confirm efficacy and guide future licencing decisions
GLP-1 receptor agonists for weight loss for perimenopausal and postmenopausal women: current evidence.
No full textPURPOSE OF REVIEW: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) have emerged as a leading pharmacologic for managing weight gain across most populations, including peri and postmenopausal women who frequently suffer from weight gain. There is a paucity of data about this specific population and how they respond to these medications. This review aims to discuss the data available about the use and effects of GLP-1 RAs in the peri and postmenopausal populations.
RECENT FINDINGS: GLP-1 RAs are consistently the most effective pharmacologic for weight loss and can be a valuable tool for use in peri and postmenopausal women.
SUMMARY: Additional research is needed to determine the risks and benefits and ideal use of GLP-1 RAs in peri and postmenopausal women
