Health Sciences University of Hokkaido Academic Repository / 北海道医療大学学術リポジトリ
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Creation of bone- and tooth-derived graft materials and their characteristic evaluation in rats
Get PDFBone defects in the oral region such as the alveolar bone and jawbone often require hard tissue regeneration from the viewpoint of oral system function recovery, and local bone regeneration is a major issue in the dental field. In clinical practice, it is common for compact bone plate to be used for transplantation to be immediately transplanted with freshly perforated autogenous bone. Therefore, we focused on ultrasonic demineralization as a rapid demineralization of perforated bone and further processing inside the bone. In this experiment, adult rat parietal bone−derived compact bone was subjected to physicochemical processing, that is, treatment with mechanical perforation and ultrasonic demineralization by 2% nitric acid. The purpose of this experiment is to observe the ultrastructure of four types of processed bones ( FBP group, DFBP group, UFBP group, UDFBP group) with a scanning electron microscope and to observe bone and cartilage induction phenomena in the subcutaneous tissue of the back of the rat after 4 weeks. Observation of the surface before implantation by SEM revealed a fibrous structure that appeared to be acid−insoluble collagen in DFBP and UDFBP. Focusing on the P and Ca elements present on the surface, DFBP and UDFBP were reduced to about 1/10 or less of FBP and UFBP. The processing of perforated plate−shaped compact bone (ultrasonic nitric acid demineralization) results in a structural change that allows cells and blood vessels to penetrate by the formation and expansion of cracks in the bone matrix. This is thought to have contributed to the osteoinduction of the space.departmental bulletin pape
Activation at a distance：new paradigm of β-arrestin dependent pathways drive mitogen-activated protein kinase signaling
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Mechano-chemical characterization of human dentin blocks and vertical augmentation by partially demineralized dentin matrix blocks on ultrasonically scratched skull or non-scratched skull without periosteum of retired rats
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History and development of the mental health social work in Hidaka district of Hokkaido.
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