Digital repository of Slovenian research organizations
Not a member yet
17604 research outputs found
Sort by
Predlog optimalnega števila in lokacij kontrolno-lovnih nastav za prezimele osebke osmerozobegasmrekovega lubadarja ( Ips typographus ) v Sloveniji za leto 2026
Get PDFPripravili smo predlog optimalnega števila in lokacij kontrolno-lovnih nastav za prezimele osebke osmerozobega smrekovega lubadarja (Ips typographus) (nastave I. serije) za leto 2026. Pri pripravi smo sledili predlogu postopka za določitev optimalnega števila in lokacij kontrolno-lovnih nastav za osmerozobega smrekovega lubadarja. Predlagamo, da se nastave I. serije v letu 2026 položi na 107 lokacijah.We have prepared a proposal for the optimal number and locations of trap logs for overwintering individuals of the European spruce bark beetle (Ips typographus) for the year 2026 in Slovenia. In preparing this, we followed the proposed procedure for determining the optimal number and locations of trap logs for European spruce bark beetle. We propose that the trap logs should be placed at 107 locations in 2026
Multilingualism in minority schools
No full textLately, the various forms of minority education (and other educational opportunities offered to immigrants and new minorities) are being used by the wider community and not only by minorities and immigrants (and their descendants). The present state of play is therefore a natural consequence of Europe’s long standing inclusive and non-discriminatory policies as well as globalisation and migration. Students’ and parents’ motives for the inclusion of speakers of majority languages in minority education programmes vary, ranging from tracing one’s roots to taking advantage of this opportunity to increase an individual’s cultural capital (with a view to a potential increase in economic capital thanks to additional (linguistic) competences). These students bring a new dynamic into the education of linguistic and/or ethnic minorities, which has both positive and negative implications. The most obvious and far-reaching are those affecting linguistic competence and multicultural awareness. The chapter reviews the data from our research exploring the Alps-Adria region, particularly two ethnically mixed areas, and focusing on: (1) Slovene secondary minority schools in Austria and (2) Italian primary schools from the coastal region of Slovene Istria in Slovenia
Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis
Get PDFBackground: The kappa free light chain (κ-FLC) index is a well-established biomarker in multiple sclerosis (MS). While the prognostic value of the κ-FLC index has been demonstrated in early relapsing-remitting MS, its prognostic value in primary progressive MS (PPMS) has not yet been investigated. Methods: In this multicenter, retrospective cohort study, patients diagnosed with PPMS with diagnostic lumbar puncture and clinical follow-up of at least 12 months were recruited from nine MS centers across five countries. At baseline, age, sex, disease duration, and the number of T2 hyperintense (T2L) and contrast-enhancing T1 lesions (CEL) on MRI were determined. κ-FLC was measured using nephelometry/turbidimetry, and the κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/albumin quotient. At follow-up, the occurrence of disability progression and the administration of disease-modifying treatment (DMT) were registered. The primary endpoint was time to disability progression. Results: A total of 121 PPMS patients were included with a median age of 53 years (25th-75th percentile: 46-59) and a balanced sex distribution (48.8% female). Multivariable Cox regression analysis revealed no significant association between the κ-FLC index and disability progression [hazard ratio (HR) 1.0, p = 0.950]. Prior use of DMT (HR 0.60, p = 0.023) and brain T2L > 9 at baseline (HR 2.22, p = 0.026) were significantly associated with disability progression. The remaining covariates, including age, sex, disease duration, and CEL, showed no significant associations. Conclusion: The κ-FLC index does not predict disability progression in PPMS, contrasting its growing role as a prognostic biomarker in relapsing MS. This highlights phenotypic differences in MS pathophysiology and underscores the need for prognostic biomarkers in PPMS
Branched-chain amino acid transferase 2 (BCAT2) deficiency
Get PDFBackground: Branched-chain amino acid transaminase 2 (BCAT2) deficiency is an autosomal recessive disorder that impairs branched-chain amino acid (BCAA) catabolism. Its clinical and metabolic features remain poorly understood due to limited reports in the literature. Methods: We report three novel cases of BCAT2 deficiency from Slovenia: one diagnosed following symptom onset, one through cascade screening of parents, and one by newborn screening. Diagnosis was established through metabolic evaluation and confirmation of pathogenic variants in the BCAT2 gene. In addition, we performed a systematic review of all previously reported cases of BCAT2 deficiency. Results: All three patients were homozygous for the NM_001190.4:c.600C > A (p.Tyr200Ter) variant, with valine concentrations at presentation of 2093, 2589, and 794 μmol/L. Only one patient was symptomatic, presenting with headaches, developmental delay, and intellectual disability, while the remaining two were largely asymptomatic. Notably, insulin resistance was observed in one of the three patients and may be associated with elevated BCAA levels. Systematic literature review identified 8 additional cases of BCAT2 deficiency. Genetic variant c.600C > A was also found in two Pakistani individuals, while the remaining variants were each reported in only a single individual. The most common clinical characteristics were intellectual disability (55%), developmental delay and other neurological symptoms (36%). Abnormal white matter findings on MRI were observed in all patients who underwent imaging. BCAA levels decreased in all patients receiving pyridoxine supplementationhowever, only 50% showed clinical improvement. Conclusion: BCAT2 deficiency displays marked interindividual heterogeneity, ranging from asymptomatic cases to severe neurological impairment, which renders its pathogenicity uncertain
