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Predictions for the future of kallikrein-related peptidases in molecular diagnostics
Get PDFKallikrein-related peptidases (KLKs) form a cancer-related ensemble of serine proteases. This multigene family hosts the most widely used cancer biomarker that is PSA-KLK3, with millions of tests performed annually worldwide. The present report provides an overview of the biomarker potential of the extended KLK family (KLK1-KLK15) in various disease settings and envisages approaches that could lead to additional KLK-driven applications in future molecular diagnostics. Particular focus is given on the inclusion of KLKs into multifaceted cancer biomarker panels that provide enhanced diagnostic, prognostic and/or predictive accuracy in several human malignancies. Such panels have been described so far for prostate, ovarian, lung and colorectal cancers. The role of KLKs as biomarkers in non-malignant disease settings, such as Alzheimer’s disease and multiple sclerosis, is also commented upon. Predictions are given on the challenges and future directions regarding clinically oriented KLK research
Degradation and by-products identification of benzothiazoles and benzotriazoles during chlorination by LC-HR-MS/MS
Get PDFNowadays, chlorination is the most prevalent disinfection method applied for water treatment in Europe. Chlorine can be supplied as sodium hypochlorite (NaOCl) which reacts in water to produce the disinfectants hypochlorous acid (HOCl) and hypochlorite ion (OCl-), otherwise known as free chlorine. Although the primary purpose of chlorination is the elimination of micropollutants via oxidation, several investigations have shown that chlorine reacts with micropollutants leading in the production of undesired by-products. 1,3-benzothiazoles (BTHs) and 1,2,3-benzotriazoles (BTRs) are classified as high production volume emerging environmental pollutants due to their broad industrial and domestic application, and even though recently several analytical methods have been applied for their determination , there is still a lack of research for their by-products’ identification. Initially, the degradation of three BTHs (BTH, 2-OH-BTH and 2-amino-BTH) and four BTRs (1-H-BTRi, TTRi, XTRi and 1-OH-BTRi) during chlorination was investigated by UHPLC-MS/MS (QqQ). Although chlorination appeared to be an insufficient degradation process for BTH and 1-H-BTRi, all their examined substituted derivatives seem to be significantly degraded when the molar ratio of sodium hypochlorite and the target analytes was between 5000:1 – 1000:1. Then, LC high resolution MS/MS (q-TOFMS) was used to investigate the formation of by-products in the chlorinated samples. Two suspect by-products of 2-amino-BTH and one of XTRi were tentatively identified based on their probable structure, mass accuracy, retention time and fragmentation and isotopic pattern. An interesting observation was the formation of 1-H-BTRi as a degradation product of 1-OH-BTRi during chlorination. Moreover, post-acquisition non-target treatment of the MS data revealed several unknown by-products of the tested analytes
Brachytherapy structural shielding calculations using Monte Carlo generated, monoenergetic data
Get PDFTo provide a method for calculating the transmission of any broad photon beam with a known energy spectrum in the range of 20 keV-1090 keV, through concrete and lead, based on the superposition of corresponding monoenergetic data obtained from Monte Carlo simulation
Late Quaternary palaeoenvironmental reconstruction of South Evoikos Gulf (east – central Aegean Sea) by benthic foraminiferal assemblages
Get PDFReport on novel spatial-keyword search techniques
Get PDFNowadays an increasing amount of web-accessible information on spatial objects becomes available to the public every day. Apart from the spatial location of an object (e.g., a point of interest), additional descriptive information typically includes textual description as well as various ratings, often user generated. Modern applications employ spatio-textual queries, which take into account both the spatial location of an object and its textual similarity to retrieve the most relevant objects. However, existing applications provide a limited functionality to the users. For example, several meaningful queries cannot be expressed by existing approaches and motivate our novel prototype system. In the first chapter, we address this limitation by supporting ranked retrieval of objects of interest by taking into account the quality of facilities in their vicinity, but also their textual similarity to user defined keywords. In the second chapter, we analyze the properties of geotagged photos of Flickr, and propose novel location-aware tag recommendation methods. Both of the above techniques are novel spatial-keyword search methods
Strong population genetic structure and contrasting demographic histories for the small-spotted catshark (Scyliorhinus canicula) in the Mediterranean Sea
Get PDFCoastal and demersal chondrichthyans, such as the small-spotted catshark, are expected to exhibit genetic differentiation in areas of complex geomorphology like the Mediterranean Basin because of their limited dispersal ability. To test this hypothesis, we used a fragment of the mitochondrial cytochrome c oxidase subunit I gene and 12 nuclear microsatellite loci in order to investigate the genetic structure and historical demography of this species, and to identify potential barriers to gene flow. Samples were collected from the Balearic Islands, the Algerian Basin, the Ionian Sea, the Corinthian Gulf and various locations across the Aegean Sea. Additional sequences from the Atlantic and the Levantine Basin retrieved from GenBank were included in the mitochondrial DNA analysis. Both mitochondrial and nuclear microsatellite DNA data revealed a strong genetic subdivision, mainly between the western and eastern Mediterranean, whereas the Levantine Basin shared haplotypes with both areas. The geographic isolation of the Mediterranean basins seems to enforce the population genetic differentiation of the species, with the deep sea acting as a strong barrier to its dispersal. Contrasting historical demographic patterns were also observed in different parts of the species' distribution, most notably a population growth trend in the western Mediterranean/
Atlantic area and a slight decreasing one in the Aegean Sea. The different effects of the Pleistocene glacial periods on the habitat availability may explain the contrasting demographic patterns observed. The current findings suggest that the smallspotted catshark exhibits several genetic stocks in the Mediterranean, although further study is needed
ΠΑΡΑΔΟΤΕΟ Α.1.2.6.: Αξιολόγηση Σχεδίου Π.Δ. Οργανισμού Πανεπιστήμιου Πατρών
No full textΣκοπός της παρούσης έκθεσης είναι να υποστηρίξει το ΥΠΑΙΘ και τα ΑΕΙ, εν προκειμένω το Πανεπιστήμιο Πατρών, στην διερεύνηση και αξιολόγηση βασικών στοιχείων του Σχεδίου Οργανισμού, σεβόμενη την αυτοτέλεια και ιδιαιτερότητα καθ’ εκάστου ΑΕΙ, έτσι ώστε να διαμορφωθεί μια συμπληρωματική άποψη για:
1. την επάρκεια, την πληρότητα και την κανονιστική συμμόρφωση του Σχεδίου Οργανισμού,
2. τη λειτουργικότητα του οργανογράμματος των διοικητικών υπηρεσιών και την επάρκεια του διοικητικού προσωπικού.
Αντικείμενο της έκθεσης θα είναι για το Πανεπιστήμιο Πατρών:
– Γενικές Παρατηρήσεις επί του Σχεδίου Οργανισμού
– Συμμόρφωση του Σχεδίου σε σχέση με τους Ν. 4009/2011, 4076/2012 και 4115/2013
– Αξιολόγηση της οργάνωσης των Διοικητικών Υπηρεσιών στο προτεινόμενο Σχέδιο Οργανισμού
– Εκτίμηση του αριθμού των αναγκαίων διοικητικών υπαλλήλων με βάση το μοντέλο ποσοτικής αξιολόγησης
– Συσχέτιση του αριθμού των προτεινόμενων διοικητικών υπαλλήλων με το προτεινόμενο Οργανόγραμμα Διοικητικών Υπηρεσιών του Ιδρύματος
– Εκτιμώμενες ανάγκες σε διοικητικό προσωπικό
Η έκθεση εκτιμάται ότι θα μπορέσει να αποτελέσει ένα χρήσιμο εργαλείο ώστε να υποστηριχθεί το Ίδρυμα στην ολοκλήρωση της διαδικασίας εκπόνησης του Οργανισμού του
ΠΑΡΑΔΟΤΕΟ Α.1.1.: Μεθοδολογία Ποσοτικής Αξιολόγησης και Εφαρμογή της στα πρώτα 8 Σχέδια Οργανισμών των Ανώτατων Εκπαιδευτικών Ιδρυμάτων
No full textImpact of the dietary supplementation with flavonoids on the metabolic fingerprint of chicken plasma. An NMR-Based Metabolomic Study.
Get PDFInfluence of Ultrasonication Parameters on Physical Characteristics of Olive Oil Model Emulsions Containing Xanthan
Get PDFUltrasonic emulsification of 20-wt.% o/w emulsions (pH 3.8) containing a food-grade emulsifier (whey protein isolate, WPI, 2.7 wt.%) and xanthan gum (XG, 0.25 wt.%) was performed. Time and amplitude of ultrasonic treatment changed in order to evaluate their influence on emulsion droplet size, viscosity, and stability (by multiple light scattering (MLS) profiles) during cold storage (10 days at 5 °C). Ultrasonic treatment duration changed from 1 to 4 min at constant amplitude of 70 %. Considering the amplitude, intervals of 40, 60, 80, and 100 % were chosen, for a constant time of 1 min. Similarly, time and amplitude conditions were used to treat solutions of XG of 1 wt.% and evaluate their influence on viscosity and how that was related to the stability of the emulsion. Increase in sonication time from 1 to 4 min led to a significant oil droplet size decrease from 1.14 to 0.89 μm (median droplet diameter). The viscosity of emulsions and XG solutions was highly influenced and considerably decreased with sonication time applied. At those conditions, an increase of backscattering was observed from 58.9 to 72.7 % after 10 days of storage, meaning that more stable emulsions, thinner and of smaller oil droplet size were produced. A similar trend was observed when the amplitude was increased, but droplet size and creaming were always greater than those noticed by changing the sonication time. However, the rate of viscosity, droplet size, and stability change was greater by increasing the amplitude rather than by changing the sonication time. © 2014 Springer Science+Business Media New York