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Design to Data for mutants of β-glucosidase B from Paenibacillus polymyxa: E26K, I170Y, and V398N
Get PDFProtein modeling aids in developing novel protein configurations that are critical in, for example, the pharmaceutical and environmental industries. However, the predictive capabilities of the protein modeling algorithms are limited due to a lack of experimental data on structure and function. To bridge this gap, Seigel Lab at UC Davis developed the Design to Data (D2D) program to catalog thermal stability and catalytic efficiency data sets on β-glucosidase B (BglB) variants. Over 300 BglB variants have been characterized. However, there are over 8400 possible BglB single-point mutations. We utilized Foldit software to design BglB mutants E26K, I170Y, and V398N. The variants were tested for catalytic efficiency and thermal stability using a calorimetric assay. Our results show that the mutants exhibited a decrease in thermal stability and catalytic efficiency. These data were uploaded to the D2D database, increasing the BglB data sets
Hymns of Babel: A Song Cycle FMUS Composition Project
Get PDFHymns of Babel Research Brief
Over the course of the eight-week faculty mentorship undergraduate scholarship period, Dr. Reed Spencer and senior Steven Day composed a twelve-song cycle on the theme of Generation Z’s interaction with social media. This piece sought to articulate the thoughts, emotions, responses, and impulses that accompany the virtual world. Many of the songs explored where we find God in our social media age, as well as how we create gods, try to act as a god, and pretend there is no God. The collaborative process began by creating a rough lyrical structure and purpose, followed by the composition of accompanying musical ideas. The scholarship involved the exploration of collaborative songwriting between faculty and student, the study of songwriting processes through published literature and previous musical works, and the documentation of musical ideas that could be shared with performers.
At the end of the eight-week period, twelve pieces had been created with demo recordings and the beginnings of notation for each piece. Throughout the following fall semester, Taylor University’s Lyric Theatre adopted the project and rehearsed weekly to produce the songs in a workshop form. The notation of each piece was completed, the songs were cast, staged, and performed for an audience on November 30th at 7:00 PM. As part of the workshop, audience members were asked to give written feedback that could help shape the future life of the song cycle. Video and audio recordings of the performance were captured, and the two composers participated in a talk back session with the audience where they responded to questions and comments about their work. Future plans include further editing of the music and lyrics in response to audience feedback, finalization and publication of materials, and submission to songwriting or new work competitions with the desire for external performance and review that might further refine the work
Disney\u27s Newsies:The Musical
Get PDFThe playbill for Taylor University\u27s performance of Disney\u27s Newsies:The Musical. Book by Harvey Fierstein. Music by Alen Menken. Lyrics by Jack Feldman.
Performed April 26-28 & May 3-5, 2024 at the Mitchell Theatre.
Disney\u27s Newsies is a vibrant and inspiring musical based on the 1992 film and inspired by the real-life Newsboys Strike of 1899 in New York City. The story follows Jack Kelly, a charismatic newsboy who dreams of a better life. When newspaper publisher Joseph Pulitzer raises the prices that newsies must pay for papers, Jack and his fellow newsboys form a union and organize a strike to fight for their rights. With the help of young reporter Katherine Plummer, the newsies rally together to challenge the powerful publishers. The musical features energetic dance numbers and memorable songs like Seize the Day and Santa Fe, celebrating themes of resilience, justice, and the strength of youth.https://pillars.taylor.edu/playbills/1385/thumbnail.jp
The Madwoman of Chaillot
Get PDFThe playbill for Taylor University\u27s performance of The Madwoman of Chaillot by Jean Giraudoux and adapted by Maurice Valency.
Performed on November 8-9, 2024 at 7:30pm and November 10, 2024 at 2:00pm in the Mitchell Theatre at Taylor University.
Jean Giraudoux\u27s The Madwoman of Chaillot, adapted by Maurice Valency, is a poetic and satirical fable that critiques capitalism and greed. The play is set in Paris, where a group of greedy businessmen plans to tear up the city to drill for oil. Their plans are discovered by Countess Aurelia, the titular Madwoman, a wonderfully eccentric and idealistic woman who believes in the goodness of humanity. Along with her fellow madwomen and a collection of other Parisian outcasts—including a Ragpicker and a Sewer Man—she devises a plan to lure the financiers into a hidden, bottomless pit in her cellar. Through this act, they condemn the corrupt men and symbolically rid the world of their destructive influence. The play is a celebration of art, love, and humanity\u27s whimsical spirit triumphing over the cold, materialistic forces that seek to destroy it.https://pillars.taylor.edu/playbills/1388/thumbnail.jp
Everybody Dramaturgical Casebook
Get PDFThis casebook provides background research and analysis for the fall play of Taylor Theatre’s 2023-24 season, Everybody by Branden Jacobs-Jenkins.https://pillars.taylor.edu/theatre-casebooks/1012/thumbnail.jp
