National Institutes for Quantum and Radiological Science and Technology
National Institute of Radiological Science: NIRS-Repository / 放射線医学総合研究所 学術機関リポジトリNot a member yet
37195 research outputs found
Sort by
In vivo evaluation of local theranostic approach to high-grade glioma with hypoxia-targeting radiopharmaceutical 64Cu-ATSM
No full textIntroduction: High-grade gliomas (HGGs) are highly malignant brain tumors with a very poor prognosis. Due to their diffuse infiltrative features, small residual tumors remain around the resection cavity even after extensive resection, leading to local recurrence and indicating the need of a novel therapeutic approach. Our clinical PET study has demonstrated that Cu-diacetyl-bis (N4-methylthiosemicarbazone) (Cu-ATSM) highly accumulated in the HGGs generally expressing hypoxia marker HIF-1α. Herein, we investigated the feasibility and efficacy of local treatment and coupled PET monitoring with 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM), a hypoxia-targeting radiopharmaceutical, to develop theranostic approaches for the local control of HGGs.Methods: The maximum tolerated dose (MTD) of 64Cu-ATSM after localadministration was determined in mice using biodistribution, dosimetry, and toxicity studies. Multiple HGG patient-derived xenograft (PDX) models recapitulating patient tumor characteristics were used for imaging and treatment studies. Imaging with PET/CT and MRI and autoradiography analyses were conducted to examine the distribution of 64Cu-ATSM after local administration. The efficacy and cytotoxic effect of 64Cu-ATSM local treatment were then investigated.Results: The MTD of 64Cu-ATSM local treatment in mice was 3.7 MBq. After the local treatment with MTD,Imaging and autoradiography analyses demonstrated high tumor penetration, distribution, and retention of64Cu-ATSM within HGG PDX tumors, with highly expressed hypoxic markers of HIF-1α and BNIP3. A single 64Cu-ATSM local treatment significantly prolonged overall survival as well as potently induced DNA double-strand breaks and apoptosis in tumors.Conclusions: Local treatment and PET monitoring with 64Cu-ATSM may be a novel theranostic approach for treating HGGs.SNMMI 2025 Annual Meetingconference poste
Trastuzumab抵抗性子宮体部漿液性がん腹膜播種に対するHER2標的アルファ線治療
No full textUterine serous carcinoma (USC) is a rare aggressive type 2 endometrial carcinoma with dismal prognosis. Peritoneal metastasis (PM) is often observed even at early stage in USC. HER2 is a therapeutic target of USC and trastuzumab, the anti-HER2 antibody, has shown benefit in the treatment of HER2 positive USC. However, the acquired resistance of trastuzumab also has been challenges to overcome for HER2 positive USC. Targeted alpha therapy (TAT) is useful not only for local tumor but also metastasis. Having the target specificity of antibody and high cell cytotoxicity and short range of alpha-particle, TAT can effectively control targeted tumor with minimal toxicity to untargeted normal tissues. Astatine 211 (211 At) is one of the attractive alpha-emitter. We have performed experimental TAT using 211At-trastuzumab to preclinical mouse model with trastuzumab resistant PM of HER2 positive USC in order to investigate the therapeutic efficacy and toxicity. We will discuss the potential of TAT as a novel therapeutic option for drug resistant PM of HER2 positive USC.第84回日本癌学会学術総会conference presentatio
GW0-Eliashberg theory with Fourier convolutions via intermediate representation
No full textWe develop a method to solve the Eliashberg equations with wavenumber- and frequency- dependent GW0 self-energy corrections by phonon-mediated attraction and screened Coulomb repulsion.Psi-k conferenceconference presentatio
Tracking Ferroelectric Domain Formation in 100 nm BaTiO₃ using Bragg-CDI
No full textBaTiO₃ナノ粒子におけるサイズ効果の理解には、ドメイン構造の可視化が重要である。従来の放射光粉末 X 線回折では粒子全体を平均した単位胞内の原子配置情報しか得られず、単一粒子全体における大域的な変位場やドメインの観察には限界があった。Bragg-CDIは単一粒子の三次元構造を直接取得可能な手法である。本研究では100 nmのBaTiO₃粒子に対して粒子構造の温度変化計測を行い、冷却に伴うドメイン構造の変化を明瞭に捉えることができた。公益社団法人日本セラミックス協会第38回秋季シンポジウムconference presentatio
Superfluoresence from helium ions:- experiment and simulation
No full textWe compare experimental and simulation results for superfluoresence from dense gaseous samples of helium ions excited by FEL pulses resonant with 3p and 4p excitation.ICPEAC 2025conference poste
レーザー駆動粒子加速における統合シミュレーション
No full textレーザー駆動イオン加速シミュレーションの手法および実際の計算例について紹介する．核融合プラズマの多階層および統合シミュレーション研究会conference presentatio
AIで読み解く脳と心、それと量子計算を脳データ解析に使う試みについて
No full text心の中に想像するイメージを脳から読み出し、映像として可視化することはできるだろうか？脳の信号から、見ている画像や運動の意図などを読み出す技術は「脳情報デコーディング」と呼ばれ、AI・機械学習の力を借りて大きく発展してきました。しかし、多くの研究で見ている画像を脳信号から復元できることは2008年ごろから示されてきましたが、心の中に想像しているイメージの外在化は難しく、課題として残されてきました。成功例を報告する先行研究は2,3件あったものの、対象をアルファベット文字や単純な図形に絞ったものに限られていました。2024年、我々は制限なしでの想起イメージの可視化に挑み、ある程度の精度で成功しました[1]。今回、これについて紹介します。また、近年行っている量子アルゴリズムや量子計算から着想を得たアルゴリズムを脳データ解析に用いる取り組みも紹介します[2,3,4]。どちらの取り組み・試みもまだまだ課題が多く、多種多様なバックグラウンドをもつBeyond AIのメンバーとその点を議論できればと思います。[1] Mental image reconstruction from human brain activity. Neural Networks. 2024: https://sites.google.com/view/mentalimagereconstruction/home[2] 今すぐ使える量子計算！？. 日本神経回路学会誌2022年12月号: https://www.jstage.jst.go.jp/browse/jnns/29/4/_contents/-char/ja[3] Quantum-inspired canonical correlation analysis for exponentially large dimensional data. Neural Networks. 2021: https://doi.org/10.1016/j.neunet.2020.11.019[4] Fast, accurate, and interpretable decoding of electrocorticographic signals using dynamic mode decomposition. Communications Biology, 2024: https://doi.org/10.1038/s42003-024-06294-3Beyond AI 第77回研究セミナーconference presentatio
古典と量子をカバーする計算科学が迫るエネルギー代謝タンパク質の機能
No full text古典と量子をカバーする計算科学が迫るエネルギー代謝タンパク質の機能について、光受容タンパク質OaPACを例に講演する。極限環境下海洋微生物等に関する 量子生命科学の研究会conference presentatio
At-211創薬
No full textMetabotropic glutamate receptor 1 (mGluR1), a key mediator of glutamatergic signaling, is frequently overexpressedin tumor cells and is an attractive drug target for most cancers. Here, we present a targeted radiopharmaceuticaltherapy strategy that antagonistically recognizes mGluR1 and eradicates mGluR1+ humantumors by harnessing a small-molecule alpha (a)-emitting radiopharmaceutical, 211At-AITM. A single doseof 211At-AITM (2.96 MBq) in mGluR1+ cancers exhibits long-lasting in vivo antitumor efficacy across sevensubtypes of four of the most common tumors, namely, breast cancer, pancreatic cancer, melanoma, and coloncancers, with little toxicity. Moreover, complete regression of mGluR1+ breast cancer and pancreatic canceris observed in approximate 50% of tumor-bearing mice. Mechanistically, the functions of 211At-AITM areuncovered in downregulating mGluR1 oncoprotein and inducing senescence of tumor cells with a reprogrammedsenescence-associated secretory phenotype. Our findings suggest a-radiopharmaceutical therapywith 211At-AITM can be a useful strategy for mGluR1+ pan-cancers, regardless of their tissue of origin.Targeted Radiopharmaceuticals Innovation Forum 2025conference presentatio
High temperature operating characteristics of 4H-SiC Active Pixel Sensors
No full textSilicon carbide (SiC) photo diodes (PDs) and active pixel sensors (APSs) were fabricated and their characteristics were investigated raising temperature from 50 to 500 degrees. Quantum efficiency (QE) of PDs was measured in the wavelength range from 200 nm to 550 nm. Output voltage of the APS was measured under dark and under UV irradiation at 250 nm. Successful operation of SiC PD and APS even at 500 degrees was demonstrated, additionally, output waveforms of the APS increased with increasing temperature. It indicates increase in the gain of SiC MOSFET as the source follower amplifier. Increased absorption of the band edge wavelength attributes to incresed output voltage.The 22nd International Conference on Silicon Carbide and Related Materials (ICSCRM 2025)conference poste