The University of Texas at Tyler
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MetaLP: An integrative linear programming method for protein inference in metaproteomics
Get PDFMetaproteomics based on high-throughput tandem mass spectrometry (MS/MS) plays a crucial role in characterizing microbiome functions. The acquired MS/MS data is searched against a protein sequence database to identify peptides, which are then used to infer a list of proteins present in a metaproteome sample. While the problem of protein inference has been well-studied for proteomics of single organisms, it remains a major challenge for metaproteomics of complex microbial communities because of the large number of degenerate peptides shared among homologous proteins in different organisms. This challenge calls for improved discrimination of true protein identifications from false protein identifications given a set of unique and degenerate peptides identified in metaproteomics. MetaLP was developed here for protein inference in metaproteomics using an integrative linear programming method. Taxonomic abundance information extracted from metagenomics shotgun sequencing or 16s rRNA gene amplicon sequencing, was incorporated as prior information in MetaLP. Benchmarking with mock, human gut, soil, and marine microbial communities demonstrated significantly higher numbers of protein identifications by MetaLP than ProteinLP, PeptideProphet, DeepPep, PIPQ, and Sipros Ensemble. In conclusion, MetaLP could substantially improve protein inference for complex metaproteomes by incorporating taxonomic abundance information in a linear programming model
The First Armadillo in Smith County
Get PDFNewspaper accounts of the first armadillos seen in Smith County, 1925-1930
Influencing Graduate Nurses through Authentic Leadership
No full textThis change project aims to understand the relationship of authentic leadership and graduate nurses through relevant research. Recent studies have indicated that authentic leadership has a potentially beneficial impact on graduate nurses. With regard to health and retention, authentic leadership is investigated as an appropriate style of leadership for new nurses. Appropriate leadership from managers and preceptors is essential when fostering graduate nurses through the early obstacles of their new professional career. With this review, insight into the outcomes of authentic leadership will validate the inclusion of the leadership framework in nurse leadership training and development programs
Change of Policy Regarding Evidence Based Practice Interventions in Postpartum Hemorrhages and Promotion of Standardization of Care
Get PDFPostpartum Hemorrhages are occurring at a devastating rate and require intervention, as postpartum women can die from hemorrhages. This project aims to establish interventions that should be a set policy, to help decrease the rate in which postpartum hemorrhages occur and the morbidity rate
What the Hydration?
No full textThe benefits of renal hydration to prevent contrast induced nephropathy in patients with CHF and Diabetes
Alternating Pressure Overlay Systems
Get PDFAlthough preventable, pressure injuries are an overwhelming problem in the healthcare system and can lead to poor quality of life, increased length of hospitalization, and unsatisfactory patient outcomes. Many cardiac surgeries take anywhere from six to twelve hours, and patients are completely immobilized for the entire length of time. Alternating pressure overlays placed on the operating room table provide tissue offloading with inflating and deflating nodes, leading to micro-movements on high pressure bony prominences. The intervention PICO question to be answered in this paper is: In intraoperative patients (P), how does the use of an alternating pressure surface (I) compared to not utilizing an alternating pressure surface (C) affect the number of operating room pressure injuries (O)
DNP Final Report: Mission Cyborg: An EBP Project Integrating Hybrid Learning in an Undergraduate Nursing Course
Get PDFIn modern times it is an expectation of students that technology be incorporated into how they receive their education. The COVID-19 pandemic brought to light how pure reliance on traditional face-to-face (F2F) learning can be detrimental to student learning. Many institutes of higher education had already implemented hybrid/blended learning prior to the pandemic and saw no difference in their NCLEX-RN pass rates. This evidence-based practice project gathered, reviewed, and synthesized evidence in order to determine if implementing different teaching strategies would maintain or improve student performance on both unit exams and end of course exit exams
A Mixed Methods Study of Cultural Competence Among Nursing Students in Kenya
Get PDFSignificance and Background: Kenya has been experiencing an increase in cultural and ethnic diversity. As a result of cultural differences, health disparities among ethnic groups in Kenya are increasing. A component of patient centered care involves the incorporation of cultural aspects of health and illness in the delivery of nursing care. Understanding cultural competence of nursing students will provide guidance on educational needs related to cultural competence.
Purpose:. The purpose of this study was to assess nursing students’ cultural competence (CC) in the areas of cultural awareness, knowledge, sensitivity, skills, encounters and desire. Nursing students’ views on caring for culturally diverse patients and how their views relate to CC were also explored.
Design: A convergent mixed methods design was used to answer the following research questions: a) What are the levels of CC in nursing students in Kenya? b) what demographic and cultural characteristics impact the students’ level of CC? c) what are the nursing students’ views on caring for diverse patients? and d) how do the nursing students’ views on caring for diverse patients compare to or explain the nursing students’ level of CC?
Methods: A convenient sample of nursing students (N = 190) from a university in Kenya were recruited. Cultural competence was assessed using a questionnaire and interviews. Descriptive, inferential statistics, multiple regression and content analyses were used to analyze responses. Common concepts from both quantitative and qualitative data were identified.
Results: Quantitative results showed that most nursing students had a high level of CC. The highest scores were in the awareness and knowledge subscales. Skills and sensitivity were ranked lower in the subscales. Working in rural areas, private healthcare settings, having taken more continuous education units (CEUs) and lower age were associated with greater CC. Qualitative and quantitative data converged for most variables in the study. Areas of divergence explained why the scores were not at the highest possible level.
Conclusion: These findings inform stakeholders in education and healthcare about nursing students\u27 needs for CC. Strategies to support nursing students’ ongoing competency are recommended
ROLE OF CMYC IN THE PROLIFERATION AND FUNCTION OF CYTOKINE INDUCED HUMAN MEMORY LIKE NK CELLS
Get PDFNatural killer cells protect against virus infection and tumors. Although initially recognized as a part of the innate immunity, several recent studies have revealed NK cells exhibit immune memory to pathogens and haptens. NK cell memory has also been observed after exposure to combination of cytokines (IL12, IL15, IL18). The cytokine induced memory like NK cells exhibited potent antitumor immunity. To understand the role of cMyc in effector function of cytokine induced memory like NK cells, the effects of cMyc chemical inhibitor and Myc gene deletion by Crispr/Cas9 were studied. We found that treatment with cMyc inhibitor (cMYCi975) reduced NK cell proliferation, IFN-γ production and partially inhibited NK cell mediated tumor cell killing. Moreover, CRISPR/Cas9 mediated deletion of Myc gene was validated using real time PCR and Myc deletion compromised NK cell proliferation. Overall, our results suggested involvement of cMyc in the proliferation and function of cytokine induced memory like NK cells