The University of Texas at Tyler
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Caveolin-1-Derived Peptide Reduces ER Stress and Enhances Gelatinolytic Activity in IPF Fibroblasts
Get PDFIdiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by an excess deposition of extracellular matrix in the pulmonary interstitium. Caveolin-1 scaffolding domain peptide (CSP) has been found to mitigate pulmonary fibrosis in several animal models. However, its pathophysiological role in IPF is obscure, and it remains critical to understand the mechanism by which CSP protects against pulmonary fibrosis. We first studied the delivery of CSP into cells and found that it is internalized and accumulated in the Endoplasmic Reticulum (ER). Furthermore, CSP reduced ER stress via suppression of inositol requiring enzyme1α (IRE1α) in transforming growth factor β (TGFβ)-treated human IPF lung fibroblasts (hIPF-Lfs). Moreover, we found that CSP enhanced the gelatinolytic activity of TGFβ-treated hIPF-Lfs. The IRE1α inhibitor; 4µ8C also augmented the gelatinolytic activity of TGFβ-treated hIPF-Lfs, supporting the concept that CSP induced inhibition of the IRE1α pathway. Furthermore, CSP significantly elevated expression of MMPs in TGFβ-treated hIPF-Lfs, but conversely decreased the secretion of collagen 1. Similar results were observed in two preclinical murine models of PF, bleomycin (BLM)- and adenovirus expressing constitutively active TGFβ (Ad-TGFβ)-induced PF. Our findings provide new insights into the mechanism by which lung fibroblasts contribute to CSP dependent protection against lung fibrosis
EXPLORING SUBSTANCE USE AND FREQUENCY IN INTERNATIONAL STUDENTS THROUGH THE LENS OF ACCULTURATION AND SOCIAL COGNITIVE THEORY
Get PDFDesign/Objective: The research is a quantitative exploratory cross-sectional survey among international students. The goal of the research was to explore the relationship between acculturation and patterns and prevalence of substance use among the participants.
Background: There is a paucity of data regarding the influence of acculturation on recreational drug consumption and the prevalence of substance use in the United States among international college students. College students are a high-risk population for drug abuse. Substance abuse among youth is a global problem that has detrimental consequences for one’s health, family, community, and educational and professional life (Makanjuola et al., 2014). Furthermore, international students are even more likely to be vulnerable to substance use, particularly in developed countries where acculturation may promote it.
Methodology: To accomplish this research a total of 260 UT Tyler international students were given online questionnaires hosted in Qualtrics survey platform through institutional email addresses. The calculated sample size for this study was 105. However, 62 participants acknowledged the survey (24% respondent rate). The questionnaire was based on questions regarding sociodemographic, acculturation, substance use frequency, perception of drug and vi alcohol culture, stress and financial status. The students were also given questions on history of substance use. The data analysis for the research study was carried out using IBM SPSS version 24.
Findings: From the analysis, 17.7% students used recreational drugs (tobacco, vaping, alcohol, marijuana, cocaine, etc.), 27.4% used prescription and dietary drugs (anxiolytics, sedatives, amphetamines, anti-depressants, anabolic steroids, orlistat, caffeine, etc.) in the previous and 51.6% students said they had not used any drugs. It was established in the research that, acculturation, course major, level of financing, religion, among other factors had little or no influence on patterns and prevalence of substance use. Lastly, father’s level of education has a direct influence on substance use among international students. International students with fathers with a high level of education were less likely to engage in substance use.
Conclusion: Surprisingly, acculturation was not significant to substance use uptake. Father’s education was important
2021 - 2022 Teaching and Learning Awards
No full textPlease join the following 2021 - 2022 Teaching and Learning Award Winners, live on Zoom, as they present on: • Patient Safety & Quality Multi-Focal Case Scenario & Debriefing - Vicki Jowell, MSN, RN; RN-BSN Coordinator • Hybrid Model Team-Based Learning with Flipped Classroom – Adaptation and Outcome from a Reflective Practice - Harrison Ndetan, M. Sc., MPH, DrPH, MD, PhD; School of Community & Rural Health • Virtual Choir Project Dr. Cameron Rose; School of Performing Arts • Transitioning a Civil Engineering Materials Lab to a Virtual Format, Dr. Michael Gangone and Dr. Michael McGinnis, Civil Engineerin
An Atypical Case of Extreme Polypharmacy
Get PDFA commonly reported definition of polypharmacy is the numerical definition of 5 or more medications daily, and definitions have ranged from 2 or more to 11 or more medications. In this case report, an extreme case of polypharmacy is presented, highlighted by the inordinate number of drugs used over time throughout the patient’s care. A 48-year-old African American female with multiple comorbidities experienced a serious adverse drug event (ADE) prompting reporting to MedWatch, the US Food and Drug Administration’s adverse drug event reporting system. The patient’s concomitant medications included 146 drug entities, across 82 therapeutic drug categories. It is apparent that the greatest influence on the occurrence of polypharmacy was the presence of multiple comorbidities, and treatment centered around addressing each morbidity with drug therapy. This case illustrates the insidious nature of polypharmacy and raises questions as to the appropriate progression and limits on the use of multiple medications
Panel Presentation: Research, Innovation, Entrepreneurship in Community and Health Wellness
No full textBarbara Chapman, DNP - Mobile Health, Telehealth and Telepsychiatry: Meeting Patients Where They Are
Sandra Petersen, DNP - Addressing Community Mental Health and Educating Students through Mobile & Telehealth Initiatives
Carol Rizer, DNP - The INTUNE Advanced Nursing Education Workforce HRSA Grant Projec
The Use of Mobility and Medication on Patient’s Perception of Pain in Hospitalized Patients with Chronic Back Pain Benchmark Study
Get PDFAccording to Boss & Huether, twenty-nine percent of Americans have been diagnosed with chronic low back pain (CLBP). This pain can affect every part of their lives leading to lost wages and decreased quality of life. CLBP is an issue experienced by many hospitalized patients. These patients may not be able to mitigate their pain as they normally would due to safety protocols in hospital settings. Exercise or mobility has been shown to decrease a person’s perception of pain. The importance of exercise and mobility in a hospital setting to help decrease a patient’s perception of pain needs further research. This narrative review synopsizes available randomized control, systematic review, and meta-analysis, a systematic review with meta-regression, and qualitative review studies of exercise programs on pain severity
Naps: A new approach to decrease patient adverse outcomes
Get PDFHospitals have been short staffed, especially during the pandemic. Due to this many staff members have been overworked causing them to become stressed, exhausted, and not alert which is resulting in adverse patient outcomes (Aiken et al., 2004). One of the solutions suggested so far is nap. Nap is a low-cost solution which can help reduce the adverse outcomes of working and help promote positive patient outcomes. This benchmark study is a guide to institute naps and will provide a detailed step-by-step instruction to anyone to ensure a successful implementation of the project.
Aiken, L. H., Hwang, W., Dines, D. F., Rogers, A. E., & Scott, L. D. (2004). The working hours of hospital staff and patient safety. Healthaffairs, 23(4), 202-212. https://doi.org/10.1377/hlthaff.23.4.202 (Links to an external site.)
The Use of Standardized Patients to Improve Communication Skills: A Benchmark Study
Get PDFEffective communication is an important skill set for all nurses to withhold. In the medical field, poor communication skills have been associated with negative patient outcomes, increase in patient dissatisfaction and complaints, faulty treatment adherence, inadequate patient education, malpractice claims and poor patient and healthcare team relationships (Lin et al., 2013). Communication is a learned skill and needs to be taught from the very beginning of nursing school. Nursing schools need to be proactive and prepare their nursing students in promoting clear communication skills to ensure patient safety and satisfaction in care. This issue led to the benchmark project that will help create a standardized patient program with a thorough literature review in hopes to improve nursing student’s communication skills
DNP Final Report: AN EVIDENCE-BASED HESI EXIT EXAM REMEDIATION PLAN
Get PDFIn a small East Texas associate degree nursing program, the average pass rate for the National Council of State Board exam fell and was below both national and state averages for three years. In an effort to identify students who may need extra preparation prior to taking the licensure exam, the college administers the HESI Exit Exam during the last semester of the program. For the last three years, between 28 and 37% of the senior class did not achieve a passing score on the exam. The project’s purpose was to evaluate the effect of a remediation plan which consisted of evidenced-based remediation strategies
The Effect of Chief Executive Officer and Board Prior Corporate Social Responsibility Experiences on Their Focal Firm’s Corporate Social Responsibility: The Moderating Effect of Chief Executive Officer Overconfidence
Get PDFThis research aims to examine how the prior experiences of the chief executive officer (CEO) and board influence the focal firm’s Corporate Social Responsibility (CSR) activities. Further, the present study examines how CEO overconfidence influences the diffusion of CSR activities. The authors theorize that overconfident CEOs are influenced more by the corporate strategies they experienced on other boards and less by the corporate strategies experienced by other directors. Through longitudinal analyses of the CSR profiles a sample of S&P 500 companies for the period 2006-2013, the study shows that CEO and board prior CSR experience are positively related to the firm’s current CSR activities. The authors find a significant positive moderating effect of CEO overconfidence on the relationship between CEO prior CSR and the focal firm’s CSR. The theory and results highlight how CEO and board prior CSR exposure may influence the focal firm’s stances toward CSR and that CEO overconfidence may have differential effects on these relationships