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Synergic action of plant derivatives and honey for high efficacy of Dawa-ul kurkum formulation against hepatocellular carcinoma
Full text linkHepatocellular carcinoma with high incidence and poor survival stands as a major global health burden. Various challenges involved in drug therapies impede their efficacy for substantial protective effects. They emphasize the necessity for the development of safe and affordable options suitable for long-term treatment. The present study has explored the therapeutic potential of traditional Dawa-ul-kurkum formulation for anticancer effects against hepatocellular carcinoma (HCC). The formulation and its individual ingredients were screened for cytotoxic effects, induction of apoptosis, and cell cycle arrest on HepG2 cell line. Dawa-ul-kurkum was further evaluated for regression of tumor growth in diethylnitrosamine (DEN) induced HCC rat models. Low, medium, and high doses of the formulation were fed orally to the test groups. A Combination of Dawa-ul-kurkum with the anticancer drug Doxorubicin was tested for assessment of adjuvant therapy. The classical dosage form with honey of each ingredient plant drug displayed enhanced cytotoxic effect and pharmacologically significant IC50 values. The Dawa-ul- kurkum formulation was superior in inducing apoptosis and arresting cells in the G0-G1 phase of the cell cycle. Significant regression of tumor growth and reversal of biochemical parameters in DEN-induced HCC rat study endorsed its prominent anticancer effect. The promising potential to induce apoptosis, cell cycle arrest, and regression in tumor growth validated the traditional Dawa-ul-kurkum formulation for anti-hepatoma activity. The study convincingly promotes the use of Dawa-ul-kurkum formulation for the development of a cost-effective and safe therapeutic strategy against HCC
Indigenous hillstream fishing practices in Telangana State, India
Full text linkThe present study deals with the traditional knowledge of various fishing techniques and practices of tribes and local fishermen in the Telangana State. Field surveys were carried out across the state during the period of 2013 to 2021 and we have documented all hillstream fishing activities by tribes and local fishermen. All hillstream fishing activities were categorized into three categories based on fish-catching methods: poisoning, trapping, and traumatizing. During the study period, we documented a total of 16 piscicidal plant species used by various tribes around the state. Bamboo traps, casting nets, constructing pseudo-littoral zones, hooks, long cloth method, pot/dish trap and stream diversion approaches were all listed as trapping methods. The technique of traumatizing involves hitting with a stone. These are all techniques that facilitate future researchers, fishermen, and aquarium traders to understand the various fishing methods used in the stream water, as well as to catch live fish for scientific studies, aquarium trades, and sustainable use of natural resources. Other recent trends discussed include high-voltage electric fishing, the use of explosives, poisoning with commercial pesticides, and bleaching powder (Ca(OCl)2) to catch hillstream fish by local fishermen in the state. Indigenous fishing practices can help to establish eco-friendly methods for aquarium fish trading, research, providing a source of income for unemployed youth in remote areas, and maintaining a sustainable utilization of natural resources
Analytics for the comparison of Mughlai and Awadhi cuisine network graphs to visualize the usage of ingredients in cuisine groups
Full text linkIndian cuisines are known for its exquisite delicacy and there are over 5000 such traditional preparations practiced in the country. Some of these cuisines are identified with cuisine families such as Mughlai, Awadhi, Udupi, Chettinad, Hyderabadi, Punjabi and so on. These cuisine groups might have emerged owing to various historical and geographical factors viz., food availability, climatic conditions, cooking traditions and cultural choices over a period. However, the divergence or convergence among the selected cuisine families other than referring to the attributes in the subjective manner, are rarely studied. This study focuses on data mining coupled with visual analytic methods for comparison of Mughlai and Awadhi cuisines
A combination Siddha drug reduces anemia among adolescent girls in Virudhunagar District of Tamil Nadu, India
Full text linkThe prevalence of anemia in India is worrisome; the Government has aimed to reduce the prevalence of anemia among women at adolescent and child bearing age. A public health initiative was undertaken to mainstream the use of Siddha drugs to combat anemia among the adolescent girls of Virudhunagar district, Tamil Nadu, India. With the assistance from the Siddha physicians in Primary Health Centers and Government hospitals, adolescent girls with anemia were identified. Interested anemic subjects were put on ABMN drug regimen (Aṉṉapēti centūram, Bāvaṉa kaṭukkāy, Mātuḷai maṇappāku and Nellikkāy lēkiyam) for 45 days. The clinical and biochemical features were studied before and after ABMN treatment. Through this program, 14,179 adolescent girls were screened for anemia and 3,783 subjects were found anemic; out of them 2,300 (86.85%) subjects completed the 45 days program. Marked reduction of various clinical features of anemia were found with ABMN treatment. ABMN treatment improved the hemoglobin content by 24.30 (N = 155), 15.96 (N = 1440) and 4.29% (P = 0.0005; N = 705) in severe, moderate and mild anemic subjects, respectively. Long term, multicentric investigations are needed to conclude the efficacy and safety of ABMN for treating iron deficiency anemia
Threads of heritage: A comparative analysis of Punjab and Thai embroidery
Full text linkThis paper discusses the significance of traditional Indian textiles, which are recognized globally for their intricate surface ornamentation techniques like embroidery, dyeing, and printing. Embroidery has been a popular technique used for centuries to adorn clothing and textiles. Different regions in India practice distinct embroidery techniques, each having unique features. The study analyzes two embroidery styles: the Hmong embroidery from Thailand and the Phulkari of Punjab. The paper summarizes the history, techniques, design, and material used for embroidery, types of stitches, end products, and the cultural significance of these traditional art forms and further analyzes the similarities and differences between the two crafts. The study found that though both embroideries share similarities in the use of colors, cultural significance, and women's art forms, they also have notable differences. These findings highlight the rich diversity of textile arts around the world and the importance of cultural heritage in preserving these traditions