Online Publishing @ NISCAIR
Not a member yet
6870 research outputs found
Sort by
Treatment of hyperemesis gravidarum accompanied by metabolic disorders by modified Liujunzi decoction, acupressure combined with rehydration
Full text linkWe aimed to assess the therapeutic effects of modified Liujunzi decoction, acupressure combined with rehydration on hyperemesis gravidarum (HG) (spleen and stomach weakness syndrome) accompanied by metabolic disorders. Two hundred pregnant women admitted from January 2019 to June 2022 were divided into an observation group (n=100) and a control group (n=100) using a random number table. The control group was given rehydration, on the basis of which modified Liujunzi decoction and acupressure were utilized for the observation group. Both groups were treated for 7 d. The total effective rate was higher in the observation group than that in the control group. Blood potassium and sodium levels increased in both groups after treatment, which were higher in the observation group (p<0.05). The observation group had a higher negative conversion rate of urinary ketone body than that of the control group (p<0.05). The scores of physical symptoms and worsening factors, fatigue, mood and restriction as well as total score of Nausea and Vomiting of Pregnancy Quality of Life decreased in both groups after treatment, which were lower in the observation group (p<0.05). No adverse reactions occurred in the control group during treatment, while 1 case of skin allergy and 1 case of stomach distension occurred in the observation group. Modified Liujunzi decoction, acupressure combined with rehydration can effectively and safely restore the electrolyte balance, shorten the time to recovery, alleviate the clinical symptoms and improve the quality of life of patients with HG accompanied by metabolic disorders
Phytochemical characterization and evaluation of the antibacterial activity of Amruthotharam kwath, a traditional polyherbal formulation on multidrug resistant clinical isolates from the respiratory tract
Full text linkAntibiotic resistance is a multifaceted medical issue affecting the global healthcare sector. Despite continued research and development to combat antibiotic resistance, the development of new antibiotics lags behind the rates of drug resistance. Among the various research strategies under development, traditional polyherbal formulations have greater potential to resolve infectious conditions caused by antibiotic resistant pathogens. Unlike monotherapy antibiotics, polyherbal formulations contain a variety of secondary antibacterial metabolites and their enhanced synergistic action renders them potent therapeutic agents. Multitarget action of phytocompounds at low concentrations poses very low selection pressure that prevents bacteria from developing new resistance mechanism against polyherbals. The study was focused on exploring the antibacterial efficacy of a traditional polyherbal formulation Amruthotharam kwath which had been used to treat respiratory tract infections, one of the leading infectious conditions prevalent in our country. Respiratory tract infection caused by multidrug resistant gram-negative pathogens leads to ineffective empirical treatments and worsens the situation. The study involves preliminary phytochemical analysis, quantification of phytoconstituents, metabolite profiling of the formulation and its antibacterial effect on multidrug resistant clinical isolates from the respiratory tract. The phytochemical analysis revealed the presence of various classes of phytocompounds with antibacterial activity. Antimicrobial assays reported promising antibacterial effect. MIC values were found to be in the range of 6.25 mg/mL-12.5 mg/mL and its MBC ranges from 6.25 mg/mL-128 mg/mL. The formulation exhibited bactericidal effect on majority of the isolates.LC-MS/QToF revealed the presence of 76 secondary metabolites, majority of which possessed antibacterial activity. The SEM image analysis confirmed complete destruction of cell wall as well as cell membrane of the pathogens. This study suggests the promising herbal therapy of Amruthotharam kwath which can be proposed as an alternative for treating infections caused by multidrug resistant pathogens
Intracellular reactive oxygen species scavenging potential of Benincasa hispida Cogn. confection
Full text linkUnchecked levels of Reactive Oxygen Species (ROS) are known contributors in numerous health issues like metabolic disorders, neurological disorders and cancers. A traditional herbal preparation, Benincasa hispida Confection (BHC) is hypothesized to balance the levels ROS because of the presence of inherent antioxidative phytocomponents. However, the specific mechanisms underlying BHC purported ROS scavenging effects at cellular level have remained unexplored. We prepared BHC, and profiled its antioxidative molecules through HPLC analysis. Preparation method included B. hispida pulp base mixed with sugar candy and various medicinal herbs as key ingredients to enhance its taste and palatability. The ability to scavenge intracellular ROS was investigated using 2',7'-dichlorofluorescin-diacetate (DCF-DA) assay after ensuring the cell viability upon treatment with the extract of BHC. BHC was rich in previously known antioxidant molecules and was able to quench intracellular ROS. B. hispida also contributed to its ROS quenching abilities along with other ingredients. This study provides valuable insights into the therapeutic utility of BHC and advocates that consumption of BHC might protect the individuals from the ROS mediated oxidative stress and associated diseases
Gamosa: Unique symbol of Assamese culture
Full text linkGamosa woven with the aspirations of Assamese folk women, stands as a significant traditional textile item among the Assamese people. The original Assamese Gamosa is the special one with red colour border, white background and a horizontally placed floral design in one end and another end is woven with red colour stripes. While the origin of this age-old textile item of Assamese culture remains untraceable to date, it has deep roots in the local heritage. Now-a-days, its popularity is highly increased due to its utility and attractive colour combination. It enters the fashion market with its diversified application in both apparel and household sectors. This paper delves into various traditional Gamosa types, highlighting the importance of preserving their cultural essence and exploring future prospects and explores the pivotal significance of Geographical Indication (GI) tagging in safeguarding and promoting the cultural heritage of Assamese Gamosa, shedding light on the unique characteristics and historical resonance encapsulated in this traditional textile.
Assessment of standardization and quality control parameters of a new formulation of Trijata; An Ayurveda formula
Full text linkTrijata is a polyherbal Ayurveda preparation containing Twak (Cinnamomum verum syn. Cinnamomum zeylanicum), Ela (Elettaria cardamomum), and Patra (Cinnamomum tamala) discussed in Ayurveda textbooks, including Bhava Prakash, Kaiyadeva Nighandu and Ayurveda Pharmacopeia, Sri Lanka. This study aimed to develop a novel preparation of Trijata incorporating C. zeylanicum leave substituting Cinnamomum tamala, due to the unavailability of C. tamala in Sri Lanka. Furthermore, quality control and standardization parameters were developed for this Novel Trijata (NT). The hot and cold aqueous extractions were subjected to qualitative phytochemical screening. Total phenolic, flavonoid contents, and in-vitro antioxidant activity were determined using DPPH and ABTS assays. Microbiological limits, heavy metal content, and physicochemical parameters including; the ash content, and extractable matter were determined for quality control and standardization. Preliminary phytochemical analysis revealed the presence of phenols, flavonoids, tannins, alkaloids, saponins, terpenoids, reducing sugars, and cardiac glycosides in NT aqueous extract. The physicochemical parameters including; 4.6±0.2% of total ash, 3.1±0.1% water-soluble ash, and 0.6±0.2% of acid insoluble ash on a dry weight basis were determined. In-vitro antioxidant activity as per DPPH and ABTS assays was dose-dependent and the highest activity was obtained with IC50 of hot water extract. Extractability was high for hot extraction. NT had high total phenolic and flavonoid content exhibited through promising antioxidant activity. The microbiological limits and heavy metal content were within the standard acceptable limits. The HPTLC profiles of this study would be more helpful to authenticate this product (NT) for drug manufacture and further studies are recommended to evaluate its biological activities for proper indications
Ethnobotany of traditional medicinal plants used in Senapati district of Manipur, Northeastern India
Full text linkThis study presents data on important ethnomedicinal plants that were gathered from Manipur's Senapati District. Modern medical facilities are lacking in this area, and traditional health care systems are still practiced. A total of 82 plant species under 46 families were documented from 23 informants. Questionnaires that were open-ended and semi-structured were used to collect the data. Ethnobotanical indices were used to indicate ethnomedicine's advantages, significance, and application. The highest ICF value was 1 for kidney diseases, general health or body weakness, and oral care, followed by skin diseases (0.76). Rhus chinensis Mill (0.52) has the highest relative frequency of citation value followed by Zingiber officinale Roscoe (0.39), Psidium guajava L. (0.39), Gynura cusimbua (D.Don) S.Moore (0.35), Oroxylum indicum (L.) Kurz (0.35). Decoction (47%) was the most commonly used method of preparation followed by raw/fresh (22%), paste (8%), juice (8%), crushed (10%), powder (2%), infusion (2%) and maceration (1%). In our study, 11 plant species were found to have a 100% fidelity level. These species could be a real natural reservoir of new biomolecule with a potential pharmacological activity. Therefore, the preservation of this heritage by documentation and scientific studies is an essential requirement
A report on the national workshop on “Capacity building in Indian Knowledge Systems: Documentation, validation, and communication”
Full text linkTraditional methods of soaking or sprouting pulses reduce the flatulence causing raffinose family alpha-galactosides in regularly used nutritious edible legumes
Full text linkPulses are an alternative sustainable and inexpensive source of protein. They are rich in carbohydrates, proteins, vitamins, and minerals. The total soluble sugars in pulses include monosaccharides, disaccharides, and oligosaccharides. Legume seeds contain raffinose family oligosaccharides (RFOs) as their primary source of sugar reserves, which drive seed germination and improve seed vigor and longevity. The RFOs are also critical during plant growth and development in unfavorable environments. However, because monogastric animals, including humans, lack the enzyme alpha-galactosidase, they cannot digest the RFOs present in legume grains, leading to the accumulation of flatus due to microbial fermentation of RFOs in the large intestine. Subsequently, large amounts of carbon dioxide, methane, and hydrogen build up in the intestine due to flatulence. Flatulence, being induced by water-soluble RFOs, it is possible to reduce the levels of RFOs in the dietary pulses by traditional soaking of legumes. Herein, we report the RFOs levels of 21 common dietary pulses consumed in various forms, such as dry grains, soaked grains, and seed sprouts. We show that seed sprouts accumulate lower levels of RFOs compared to fresh vegetables. We hypothesize that the RFOs levels increase when the filled grains desiccate to mature and decrease when the desiccated seed commits to germination. Our study suggests incorporating highly nutritious pulses, such as sprouts, into diets to combat flatulence