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Influence of L-serine on the Effects of Anticancer Drugs on Esophageal Cancer
Get PDF食道がんが局所に進行する病変の場合には、術前化学放射線療法などでがんを縮小させてから手術を行うことが一般的である。これまでの研究で、術前化学放射線療法前の食道がん患者において、L-serine の血中濃度が高いと食道がんに対する術前化学放射線療法の治療効果が出にくく、その長期予後も悪い可能性が明らかになっている。そこで本研究では、ヒト食道扁平上皮がん細胞株を用いて、L-serine が食道がんに対して使用される抗がん剤である cisplatin と 5-fluorouracil の効果に及ぼす影響について検討した。その結果、cisplatin や 5-fluorouracil がヒト食道扁平上皮がん細胞株の細胞増殖を阻害することを確認できた。さらに、L-serine 自身がヒト食道扁平上皮がん細胞株の細胞増殖に影響を与えない濃度であっても、cisplatin や 5-fluorouracil の細胞増殖阻害効果を抑制できることを明らかにした。これらの結果は、L-serine の体内レベルが高い場合には、cisplatin や 5-fluorouracil による治療効果が抑制される可能性を示唆している。食道がんに対する化学放射線療法治療の際にL-serine の低減が、その治療効果の向上が期待できるかもしれない。When esophageal cancer progresses locally, it is common to perform surgery after shrinking the cancer with preoperative chemoradiotherapy. Previous studies have shown the possibility that in the patients with esophageal cancer before preoperative chemoradiotherapy, if the blood concentration of L-serine is higher, the therapeutic effects of preoperative chemoradiotherapy against esophageal cancer is not better, and the longterm prognosis is also poor. In this study, we investigated the effects of L-serine on the effects of anticancer drugs cisplatin and 5-fluorouracil against esophageal cancer using human esophageal squamous cell carcinoma cell lines. As a result, we confirmed that cisplatin and 5-fluorouracil can inhibit cell proliferation of human esophageal squamous cell carcinoma cell lines. Furthermore, even at the concentrations where L-serine itself did not affect cell proliferation in human esophageal squamous cell carcinoma cell lines, it could suppress the inhibitory effects of cisplatin and 5-fluorouracil on cell proliferation. These results suggest the possibility that the higher levels of L-serine in the body may lead to suppression of the therapeutic effects of cisplatin and 5-fluorouracil, and reduction of L-serine may be expected to improve these therapeutic effects.departmental bulletin pape
Married Couples’ Mutual Recognition of Child‒rearing Behavior and Associated Stress
Get PDF本研究では、夫婦の育児行動の認識が育児ストレスとどのように関連するのかを調べることを目的とした。0～6歳の子どもをもつ母親と父親263名を対象に、①自身の、②配偶者の、③配偶者への理想の育児行動量の程度を尋ね、それぞれの認識の差異と育児ストレスとの関連を検討した。その結果、全体を通して、女性の方が男性よりも育児ストレスが高いことがわかった。また、夫が認識する妻の育児行動量が、夫が理想とする妻の育児行動量よりも少ない夫婦は、そうでない夫婦よりも育児ストレスが高いことが分かった。さらに、育児サポートの有無や数、夫婦の就業形態も育児ストレスと関連を示すことが示され、育児サポート数の多さと育児ストレスの高さが関連することも明らかとなった。加えて、共働きで育児サポートが保育園のみの夫婦よりも、妻が無職で育児サポートがある夫婦の方が、育児ストレスが高いことがわかった。夫婦の育児ストレスの低減のためには、夫婦で手の足りないところは育児サポートを受け、夫婦で協働して育児に取り組むことが大切ではないかと考えられた。Recently, women have been advancing socially, unhindered by traditional gender roles. However, the obligations of housework and childcare have not decreased, and the problem is that women are more burdened and stressed than men. To reduce the stress of child‒rearing for women, we thought it essential for men to participate in this activity as spouses. In this study, we examined both spouses’ child‒rearing behavior and associated stress. The
subjects surveyed were mothers and fathers with children aged 0-6. Regarding the childcare involvement scale, we asked respondents about themselves, their spouses, and their views on the ideal amount of child‒rearing practice for their spouses. In addition, we investigated the effects of child‒rearing stress by focusing on mutual recognition of their child‒rearing behavior. The study results demonstrated that women had higher child‒rearing stress than men in almost all analyses. Couples experienced higher child‒rearing stress when husbands estimated their wives’ child‒rearing labor to be lower than what was believed to be the ideal amount. The presence or absence of child‒rearing support, the number of supporters for child‒rearing, and the couple’s employment status also affected stress. We also found that the presence, number of supports and the couple’s type of employment also impacted childcare stress. In order to reduce the stress of childcare for couples, it is important for couples to work together on childcare while receiving childcare support in areas that are out of reach for couples.departmental bulletin pape