Tsurumi University & Tsurumi College: Institutional Repository / 鶴見大学・短期大学部機関リポジトリ
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The forming of the tale about Otake-Dainichi : approach through the Kaichō-Engi pamphlets, Dewa-Sanzan faith and the topography of Edo
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A study on institution and penetration of philosophy related to educational philosophy in kindergarten
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The effect of sonic toothbrushes in assisted tooth brushing on plaque removal - Part 2 Comparison of different brushing time-
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Evaluation of adsorption property of stain from teas onto apatite by QCM-A
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Prosthetic treatment for disabled patients : A case report of the creation of a metal structure denture using FGP technique
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- A Systematic Study of Calligraphy Textbooks Used at Senior High School II -
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The Practices of Early Childhood Education and Care in a Buddhsit Based Kindergarten:Wishing for the happiness of the children
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Elucidation of the salivary secretion regulation mechanism through mitochondrial function control by estrogen
Get PDF研究成果の概要（和文）：本研究では、エストロゲンの唾液分泌能への関与とその分子機構を明らかにするために、OVXによる早期更年期マウスをモデル動物として解析した。OVXの血中エストロゲン濃度の低下に伴って唾液分泌が低下し、閉経時の口腔乾燥症のモデル動物を作製することができた。さらに、エストロゲンの補給は唾液分泌量および腺房収縮量を改善し、エストロゲンは唾液腺の唾液分泌能と大きく関連することが示された。この現象のメカニズムとして、エストロゲンによるミトコンドリア機能の制御に着目して解析を行なった。結果、エストロゲン量の変化に伴ってミトコンドリアの質的変化、おそらくは形態変化が起こることが示唆された。研究成果の概要（英文）：In this study, in order to clarify the involvement of estrogen in salivary secretion ability and its molecular mechanism, early menopausal mice by OVX were analyzed as model animals. Salivary secretion decreased with OVX decrease of blood estrogen concentration, and model animal of xerostomia in menopause could be constructed. Furthermore, supplementation of estrogen improved the amount of saliva secretion and acinar shrinkage, and it was shown that estrogen is greatly related to the salivary secretion ability of the salivary glands. As a mechanism of this phenomenon, focusing on the control of mitochondrial function by estrogen, we analyzed mitochondrial function and others. As a result, it was suggested that a qualitative change in mitochondria, probably a change in morphology, accompanying the change in the amount of estrogen occurred.・2017(平成29)年度 科学研究費補助金 基盤研究(C) 研究成果報告書・研究期間 (年度)：2015-04-01 – 2018-03-31・研究分野：病態系口腔科学研究課題/領域番号 : 15K11091research repor