College of Saint Benedict and Saint John's University
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Single-cell RNA Sequencing (scRNA-seq) Exploratory Analyses to Investigate Aging-dependent Changes and Regional Heterogeneity in Glial Cells
Get PDFMy thesis project research consisted of single-cell RNA-sequencing and bioinformatics using R programming and Neuroscience Multi-omic Data Archive (NeMO) Analytics to examine the impact of aging, brain region, and other variables on the genotypes and phenotypes of oligodendrocytes (OLGs) and oligodendrocyte precursor cells (OPCs). The overarching goal was to increase understanding of glial cell fate and function. After determining bioinformatical findings, follow-up wet-bench experiments were performed to validate results. RNA in situ hybridization and immunohistochemistry were performed to confirm differential gene expression across cell types and brain regions. These experiments also revealed any changes in oligodendrocyte (OLG) development and maturation with the loss of the gene of interest (Choi et al., 2018). The conclusions impact the broader neurobioinformatics field, specifically revolving around the relationship between neural-glial cell interactions and neurodegenerative diseases
“La comédie musicale française d’entre-deux guerres: un coup de commercialisation et le cas de Dédé.”
No full textLate Cretaceous Dinosaur Tracks from the Iron Springs Formation, Iron County, Utah
Get PDFLocated in Iron County, Utah, the Parowan Gap dinosaur track site contains over one hundred natural casts of non-avian dinosaur tracks preserved in sandstones and siltstones of the Late Cretaceous (≈83 Ma) Iron Springs Formation. For this study, the authors returned to the area to survey for and describe previously unidentified tracks. Many tracks from this new study occur as in situ casts found on the basal surfaces of sandstones deposited by braided and meandering rivers on the coastal plain of the Western Interior Seaway, with some specimens from fallen talus blocks. Over the course of two years, the research team identified and recorded a total of 31 specimens. The results comprise tracks that resemble a minimum of at least five ichnotaxa including Caririchnium, Amblydactylus, Ceratopsipes, Magnoavipes, and Dromaeosauripus. The most common and well-recognized ichnogenus recorded in the Iron Springs Formation is Caririchnium, which likely represents ornithopod dinosaurs. We also identified two Ceratopsipes tracks in a fallen sandstone block. The pair of tracks are significant because they are the second set from the ichnotaxa found at Parowan Gap. Together the Parowan Gap Ceratopsipes samples represent the oldest ceratopsian tracks in Utah. The potential Dromaeosauripus specimen represents a small theropod dinosaur. This specimen is of great interest because theropod tracks, especially dromaeosaur tracks, are less common in the Iron Springs Formation, with a total of seven tracks reported from previous studies. If this is an appropriate interpretation, it would make the potential Dromaeosauripus track the youngest dromaeosaur trace fossil in Utah
Collegeville Connections: The Jubilee Promise: Biblical Solutions to the Global COVID-19 Crisis
No full textSpurred by the COVID-19 pandemic, the world is experiencing the worst economic crisis since the Great Depression. As world leaders debate solutions, an interfaith movement is proposing answers from religious teachings and the Hebrew and Christian scriptures. The White House, US Congress, G20, G7, IMF and United Nations are implementing solutions proposed by Jubilee USA Network
The Mark Kennedy Frontiers of Freedom Lecture Series | U.S. Diplomacy & Foreign Policy: Insights from an Insider
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