30035 research outputs found
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Modeling of Kenworth North Docks and Testing Facility
No full textModeling Truck flows around the Kenworth facility to determine optimal conditions
Team Wheezer: Respiratory Health Monitoring Application
No full textThis project focuses on a prototype device for respiratory health monitoring and its corresponding application
Up4
No full textThe Up4 software is an event planning tool used to find people to participate in activities with within a local are
Cannabis Arteritis with Ischemic Necrosis of the Great Toe
No full textWe present a case of cannabis arteritis to emphasize the importance of considering this diagnosis in young individuals with a strong history of cannabis use, absence of cardiovascular risk factors, and normal laboratory findings
The Last Moments of a Star: How Accreting Neutron Stars Rewrite the Periodic Table
No full textI will present a poster detailing my work on studying accreting neutron stars using a new detector system called ASLAN that I designed and commissioned. This detector system enables me to study nuclear reactions that could answer some profound questions humanity has such as where did the heavy elements like gold, platinum and uranium came from? what happens when matter is pushed to its extreme limits
Mechanochemical Cascade Synthesis of Imine-based Metal-organic Frameworks
No full textMetal-organic frameworks (MOFs) show remarkable potential in a broad array of applications given their physical and chemical versatility. Classical synthesis of MOFs lies in solution chemistry at elevated temperatures to achieve reversible metal-ligand bond formation. These harsh conditions may not be suitable for chemical species sensitive to high temperature or prone to deleterious reactions with solvents. Mechanochemistry not only features advantages of short reaction time, minimum solvent, high reaction yield, and high degree of synthetic control, but also presents an opportunity to incorporate challenging chemical species, which remain difficult to achieve under solvothermal conditions. Here we report a compelling mechanochemical synthetic strategy that provides straightforward access to a subfamily of historically challenging imine-based MOF material
Immunolabel imaging of plasma membrane Ca pumps (PMCA-pan, or PMCA2) implicates the apical cilium on receptor cells as the transduction site for ancestral passive electrosense in cutaneous ampullary organs of two Acipenseriforme fishes
No full textI will present the findings out a study I worked on; the study was about identifying the site of signal transduction on paddlefish electroreceptor cells
Regulation of Microtubule Stability by Tubulin Phosphorylation in Arabidopsis thaliana Under Altered Gravity Conditions
No full textMicrotubules play a critical role in plant growth, development, and responses to environmental stimuli, including gravity. The BRIC-20 experiment, which analyzed proteomic and transcriptomic changes in Arabidopsis seedlings grown on the International Space Station (ISS), identified differential phosphorylation of 16 peptides in microgravity, including tubulin-α 1, 3, 4, and 6, which were preferentially phosphorylated at T349 on Earth. Phosphorylation at this site is associated with microtubule depolymerization, suggesting that reduced phosphorylation in microgravity may contribute to increased microtubule stability. Given the established role of microtubules in cellulose deposition, cytoskeletal organization, and gravity sensing, this study aims to investigate the regulatory function of tubulin phosphorylation in microgravity-induced microtubule dynamics. To elucidate this relationship, knockout mutants will be generated to assess the role of tubulin phosphorylation in root development, with phenotypic analyses focused on root curvature, gravitropic set point angle, and growth responses under clinostat-based altered gravity conditions. Additionally, phospho-mimic (T349E) and phospho-inhibitory (T349A) mutants will be constructed to determine whether constitutive phosphorylation or its inhibition influences microtubule organization, root growth directionality, and cellular stress responses. These mutants will be characterized through live-cell imaging of microtubule dynamics, reactive oxygen species (ROS) quantification, and cellulose deposition assays to evaluate how phosphorylation affects microtubule stability and structural integrity. Given that microtubule depolymerization is induced under hyperosmotic stress and ROS fluctuations, the potential role of ROS-mediated cytoskeletal adaptation under altered gravity conditions will also be explored. This study will provide insights into how tubulin phosphorylation modulates microtubule stability and plant adaptation to spaceflight conditions. Understanding these regulatory pathways may inform future strategies for optimizing plant growth and biomass production in microgravity, with implications for space agriculture and plant-based life support systems in long-term space missions
Managing Uncertainty Through Information Exchange During Urban Infectious Disease Outbreaks
No full textThis project explores how information exchange influences risk perception and coping mechanisms in urban populations during infectious disease outbreaks, using Uncertainty Management Theory to examine the roles of social networks, media, and misinformation
Synthesis and Antibacterial Activity of Novel Derivatives of Natural Product
No full textThe increase in the emergence of antibiotic resistance has reduced the number of effective antibacterial drug pipelines. The synthesis of novel therapeutics is crucial to prevent the 10 million deaths projected by 2050 from antibacterial resistance. Our research focuses on synthesizing novel scaffolds from natural products. These scaffolds are used to generate a library of active antibacterial agents