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Bird Monitor Team 1
No full textThe aim of the Bird Monitor Project is to design a semi-autonomous system to collect video, audio, and other environmental data within cavity nesting birdhouses
Disrupting the Narrative: Understanding Food Insecurity Among International Students
No full textThis research aims to disrupt these narratives by exploring the complexities of food insecurity among international students, highlighting their diverse experiences, current interventions, and advocate for more inclusive support systems for students
Agricultural Adaptation Practices to Climate Change in the Coastal Region of Bangladesh
No full textBangladesh is an agrarian country, with one-third of its land belonging to coastal and offshore areas, making it vulnerable to climate change
Characterization of a (TomEP) a tomato extensin peroxidase in vivo
No full textCharacterization of a (TomEP) tomato extensin peroxidase in viv
2D VTuber Model - Freya Cybrix
No full textA fully rigged 2D VTuber model that is controlled by the user\u27s facial movements and expressions
AI Healthcare Transparency
No full textMeasuring if AI transparency in healthcare will lead to an increase in patient provider satisfaction and attitude towards to healthcare A
Collective and Cultural Memory in Transitions to Justice: A Case Study of Cambodia and South Africa
No full textA comparative historical approach to Cambodia and South Africa\u27s rebuilding after national trauma through the lens of cultural memory
Promoting Interfaith Harmony: A Critical Analysis of the Rawadari March in Sindh and Its Role in Combating Religious Intolerance
No full textthematic analysis of rawadari march news coverag
Elucidating the Role of Prohibitin-1 and Erlins in Lipid Metabolism and Cancer Progression Following UV Irradiation
No full textUltraviolet (UV) radiation is a major environmental contributor to skin cancer, primarily by inducing DNA damage and disrupting key cell signaling pathways.1 In this study, we investigated the roles of Prohibitin-1 (PHB-1) and Erlins, both members of the SPFH protein family,2 in mediating the cellular response to UV-induced stress. Both PHB-1 and Erlins are associated with lipid rafts, specialized membrane microdomains that organize signaling molecules.3 PHB-1 is involved in regulating apoptosis, maintaining mitochondrial integrity, and cell cycle regulation,4, 5while Erlins play key roles in ER-associated degradation (ERAD), regulating lipid metabolism, and apoptosis.6 Our results showed that while total PHB-1 levels remained unchanged after sUV exposure, nuclear translocation of PHB-1 occurred at different time points post-sUV exposure, indicating its role in the nuclear stress response. This translocation, as well as self-aggregation of PHB-1, was found to be cholesterol-dependent, highlighting the importance of lipid rafts in PHB-1 function. The self aggregation of PHB-1 was observed in both HaCaT and MEF cells, suggesting a common mechanism linked to apoptosis regulation under sUV stress. Initial Proximity Ligation Assay (PLA) results indicated increased interaction between PHB-1 and E2F1 specifically at 1 hour post sUV exposure, potentially playing a role in cell cycle regulation. The role of Erlins in ERAD, lipid metabolism, and apoptosis in response to UV exposure is still being investigated and will be further explored in future experiments. Given the critical role of lipid metabolism and ER stress in the development of cancer, understanding Erlins’ involvement in these processes could provide new insights into how UV-induced cellular stress contributes to skin cancer progression. This study is part of our broader effort to uncover the molecular mechanisms driving sUV-induced skin cancer, with the ultimate goal of identifying potential therapeutic targets