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ITGB1 Knockdown Alters Apoptosis and Proliferation in Ewing Sarcoma Cells
No full textIntegrin beta 1 (ITGB1) is an adhesion receptor that link cells to the extracellular matrix and regulates pathways involved in survival, proliferation, and migration. In order to understand its role in Ewing Sarcoma, we applied CRISPR-Cas9 with two guide RNAs to knock down ITGB1 in ES8 cells. We then assessed changes in cell growth, death, movement, and gene expression using Incucyte live-cell imaging, colony formation assays, wound healing assays, and qRT-PCR. qRT-PCR showed partial ITGB1 reduction, with ITGB1_gRNA2 producing the strongest decrease. ITGB1_gRNA2 also led to a small increase in caspase activity and a 20-30% increase in proliferation at the later time intervals. Migration remained unchanged, and colony formation varied with density but did not have statistical significance. Partial ITGB1 knockdown produced small but measurable effects on apoptosis and proliferation so ITGB1 does contribute to survival signaling in ES8 cells but may require extending imaging, improved qRT-PCR controls, and more replicates to help clarify these results.https://commons.stmarytx.edu/mecofdis/1000/thumbnail.jp
St. Mary\u27s School of Law Graduation, 2025 (December)
No full texthttps://commons.stmarytx.edu/grad2025dec/1001/thumbnail.jp
St. Mary\u27s School of Law Graduation, 2025 (December)
No full texthttps://commons.stmarytx.edu/grad2025dec/1013/thumbnail.jp
Lawtina Network Summit, St. Mary\u27s University School of Law, 2024
No full texthttps://commons.stmarytx.edu/lawtina2024/1001/thumbnail.jp
Aspen Leading Edge Podcast, Episode 97: The Past and Future of AALS with Melanie Wilson and Austen Parrish
No full textMelanie Wilson, Dean of Washington and Lee University\u27s School of Law, and Austen Parrish, Dean of UC Irvine School of Law, discuss Melanie’s year as president of AALS. They also share the changes the organization has made throughout the years. Austen provides hopes for his upcoming year as president of AALS.https://commons.stmarytx.edu/edge/1066/thumbnail.jp
Sarita Kenedy East Law Library 40th Anniversary
No full texthttps://commons.stmarytx.edu/skell40/1001/thumbnail.jp
Resisting “Chicana and Latina Syndrome”: Preserving Difference across Feminist Accounts of the Self
No full textThis paper considers feminist Chicanx and Latinx philosophers’ theories of the self and takes up the call that we must resist the tendency to clump Chicanx and Latinx identity together. In this paper, I respond to the work of Latina feminist theorist, Carmen Lugo-Lugo, in which she addresses the dangers of homogenizing Chicanx and Latinx identity and insists that we must take seriously the differences between the two identities. While more attention has been given to Chicanx and Latinx work in recent philosophical literature, little has been done to track distinctions between Chicanx and Latinx theories of the self. I consult the works of Latinx and Chicanx feminist philosophers, including Mariana Ortega, María Lugones, Gloria Anzaldúa, Jacqueline Martinez, Norma Alarcón, and Linda M. Alcoff, in order to demonstrate the differences between their descriptions of lived experience and theories of the self. My account reveals that Chicanx and Latinx theories of the self-differ in three major ways: (1) in the history that gave rise to the term Chicanx, (2) in the differences between Latinx and Chicanx lived experience, and (3) in the worlds that Chicanxs and Latinxs belong to. This paper thus illustrates how, by failing to take seriously these differences, we risk further homogenization and/or erasure of multiply-marginalized selves.https://commons.stmarytx.edu/msrjs/1053/thumbnail.jp
The Coloniality of Gender and Class: Analyzing Maria Lugones Decolonial Feminism
No full textThis paper examines Maria Lugones\u27 theory of the colonial/modern gender system as a foundation for her framework of decolonial feminism. Lugones argues that because of colonialism, our society has gendered hierarchies. These hierarchies dehumanize Indigenous women and enforce European heterosexual norms. Drawing from Anibal Quijano’s concept of coloniality of power, Lugones expands the idea with the coloniality of gender. She emphasizes how race, gender, and sexuality are constructed by colonial violence. Lugones offers a powerful critique of traditional feminism’s Eurocentric bias. This paper aims to investigate the overlooked concept of class oppression to achieve a decolonial feminism. Applying the work of Iris Marion Young’s theory of structural injustice and the concept of the “Five Faces of Oppression, specifically exploitation and powerlessness, this work shows how economic hierarchies intersect with colonial and gendered structures. A case study on women garment workers in Bangladesh is used to illustrate how global capitalism reinforces the gendered labor hierarchies that are rooted in colonialism and patriarchy. This expanded framework accounts for the lived experiences of marginalized women and offers a more inclusive approach to feminist resistance.https://commons.stmarytx.edu/msrjs/1039/thumbnail.jp
Aspen Leading Edge Podcast, Episode 132: Problem Solving in Securities Regulation with Donald Langevoort, Ann Lipton, and Patrick Corrigan
No full textDonald Langevoort, Georgetown Law, Ann Lipton, Colorado Law, and Patrick Corrigan, University of Notre Dame, discuss the eleventh edition of their Securities Regulation casebook. They discuss the constant changes in the field and how Bitcoin and other cryptocurrencies are handled under securities regulation. They also share their thoughts on how the field is on a global scale.https://commons.stmarytx.edu/edge/1101/thumbnail.jp