12691 research outputs found
Sort by
The Effects of Panobinostat on Cellular Signaling Pathways and How it Relates to Antitumor Activities in Ewing Sarcoma Cancer Cells
No full textEwing sarcoma is a rare and aggressive cancer that primarily affects the bones and surrounding soft tissues, most commonly in children and young adults. Although the exact etiology remains unclear, a well-documented cause involves a chromosomal translocation resulting in the fusion of the EWSR1 and FLI1 genes. This fusion produces abnormal proteins that disrupt normal gene expression, cell signaling, and RNA processing, contributing to tumorigenesis. Prognosis varies significantly depending on the extent of metastasis, with 5-year survival rates ranging from 82% in localized cases to 39% in metastatic cases. Standard treatments include chemotherapy typically involving vincristine, doxorubicin, etoposide, and cyclophosphamide—surgical tumor resection, and limited use of radiation therapy. Chemotherapy often results in adverse side effects such as nausea, alopecia, mucositis, and diarrhea, particularly concerning in pediatric patients. Emerging therapeutic approaches include the use of histone deacetylase (HDAC) inhibitors such as Panobinostat. HDAC inhibition can restore the expression of genes involved in tumor suppression, including p53 and histones, promoting apoptosis in cancer cells. This mechanism has shown promise in various cancers, including prostate and breast cancer, and may offer potential benefits for Ewing sarcoma treatment by reactivating antitumor pathways suppressed by HDAC overexpression.https://commons.stmarytx.edu/biostulab25/1004/thumbnail.jp
A Bitter Brew For Cancer: EGCG’s Impact on Ewing Sarcoma Cells
No full textEpigallocatechin Gallate (EGCG), a powerful antioxidant found in green tea, is an abundant treatment to treat Ewing Sarcoma cells, a pediatric cancer affecting the skeletal system. Given EGCG’s known role in other cancer treatments, these tests aim to investigate its effects as a standalone natural compound on Ewing Sarcoma cells. Focusing on the PI3K/AKT pathway, if the PI3K/AKT pathway is inhibited by EGCG, then it will lead to reduced cell survival and proliferation of EW8 cells. Using cell culture techniques, IncuCyte-based IC50 analysis, caspase 3/7, RNA purification, cDNA synthesis, and qRT-PCR, EGCG’s impact was assessed on cell apoptosis and gene expression. Results showed that EGCG did affect Ewing sarcoma cells by inducing apoptosis in a dose-dependent manner, though its effects were less potent than hypothesized. These findings suggest that while EGCG exhibits anticancer properties, it may be more effective in a synergistic manner rather than as a standalone therapy.https://commons.stmarytx.edu/biostulab25/1006/thumbnail.jp
Navigating Beyond the Workplace: Examining the Need for ADA-Mandated Workplace Travel Accommodations
No full textFrom Feedback Loops to Feedback Literacy: Using the Feedback Literate Professor’s Toolkit to Maximize Students’ Academic and Professional Success
No full textAspen Leading Edge Podcast, Episode 122: Product Liability and AI with Mark Geistfeld
No full textMark Geistfeld, of NYU Law, discusses the third edition of his casebook, Product Liability Law in the Age of AI, which highlights new problems and cases related to artificial intelligence. He discusses specific cases related to Amazon Marketplace, video games, social media, and self-driving vehicles, such as Waymo.https://commons.stmarytx.edu/edge/1091/thumbnail.jp
Lawtina Network Summit, St. Mary\u27s University School of Law, 2025
No full texthttps://commons.stmarytx.edu/lawtina2025/1000/thumbnail.jp