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The Effect of Epigallocatechin Gallate (EGCG) and Alpha L-Mangostin on TP53, BAX, and VIM Gene Expression and Apoptosis in Ewing Sarcoma Cells
No full textEwing Sarcoma (ES) is a malignant pediatric bone tumor driven by chromosomal translocations and fusion oncogenes with limited targeted treatment options. This study investigated the chemopreventive potential of two natural compounds, Epigallocatechin Gallate (EGCG) found in green tea, and Alpha L-Mangostin from mangosteen, on apoptosis and gene expression in ES cells. We hypothesized that EGCG and Alpha L-Mangostin treatment would induce apoptosis and downregulate cancer-promoting genes. To test this, we performed tissue culture, IC50 assays, caspase-based apoptosis detection, RNA purification, cDNA synthesis, and qRT-PCR on ES cell lines treated with a high and low concentration of the two compounds. Our findings showed that both compounds induced caspase-mediated apoptosis and altered the expression of target genes such as TP53, BAX, and VIM. Notably higher concentrations of EGCG reduced TP53 and VIM expression, while Alpha L-Mangostin significantly reduced BAX expression. These results support our hypothesis and suggest that EGCG and Alph L-Mangostin may contribute to cancer treatment strategies via gene regulation and apoptosis induction in Ewing Sarcoma cells.https://commons.stmarytx.edu/biostulab25/1007/thumbnail.jp
Before “Once Upon a Time”: Creative Class Exercises That May Foster Law Student Proficiency in Gathering Information During A Client Interview
No full text“It’s Just Rap”: Why Texas Courts Must Presume Rap Lyrics Inadmissible as Evidence in Criminal Trials
No full textA Seventh Amendment Remedy for Housing Instability
No full textAfter the 2023-2024 Supreme Court term, housing advocates despaired over the expected, yet still unwelcome, decision in City of Grants Pass v. Johnson. While focusing on this case is understandable, this Article suggests that scholars, policymakers, and advocates should train their focus on another, perhaps less expected case from the previous Supreme Court term: SEC v. Jarkesy.
In Jarkesy, the Court affirmed a defendant\u27s constitutional right to a jury trial in an administrative proceeding that sought to enforce a right similar to one found at common law. The Court\u27s capacious interpretation of the Seventh Amendment in Jarkesy has implications for state-law matters, like eviction suits, that are more squarely rooted in the common law than the enforcement of federal securities regulations at issue in that case.
These implications translate to the broader effort to mitigate housing instability. This Article argues that Jarkesy invites advocates to respond creatively to the ongoing housing affordability and eviction crisis and sets forth a three-part strategy to expand tenants\u27 rights, reframe public perceptions of eviction trials, and increase democratic participation in the eviction process to serve as a check against the presumptions embedded in summary process
Misaligned: An Update on Trends in Data Privacy Laws and Their Effect on Individuals
No full textIn 2021, a data privacy white paper was published with the support of the Center of Consumer Law and Education-a joint initiative with West Virginia University and Marshall University. That paper provided a comprehensive overview of data privacy around the country (and indeed, a look around the world) and discussed various ways that consumers engage with data and data privacy issues-while focusing on West Virginia and the issues that the state\u27s residents face. Specifically, the paper provided the results of a survey of West Virginians and a set of focus groups held to discern what consumers in the state consider the most important issues that they face with regard to their privacy.
A second edition of this white paper was published in July of 2024, to provide readers with an accurate assessment of the current landscape and issues regarding ways that data, its benefits, and the harms involved in its misuse can intersect. The white paper proposed twelve general principles to consider in relation to data privacy policy. The principles were designed for both businesses and legislators, to help these constituents by providing guidelines for each to consider as they begin considering what makes for robust data privacy.
In this essay, we attempt to provide guidance for states that have not yet passed a data privacy bill. To that end, we highlight four general principles taken from the white paper that we believe would help policy makers and legislatures in those states create a robust data privacy bill and analyze why such protections are needed. By analyzing the work of other lawmakers and identifying how components of data privacy bills in other jurisdictions align with our general principles, we hope to provide helpful guidance regarding what an optimal data privacy law should look like-especially in light of survey information showing consumers\u27 proprietorial view of the data
Lawtina Network Summit, St. Mary\u27s University School of Law, 2025
No full texthttps://commons.stmarytx.edu/lawtina2025/1006/thumbnail.jp
Lawtina Network Summit, St. Mary\u27s University School of Law, 2025
No full texthttps://commons.stmarytx.edu/lawtina2025/1008/thumbnail.jp