18054 research outputs found
Sort by
Food Waste in the United States
Get PDFThis project is centered around the food waste problem in the United States and around the world
Models of the Sociology Minor at Institutions of Higher Education in the United States
Get PDFAlthough the structure and content of the sociology major has been addressed by a variety of scholars and several American Sociological Association (ASA) task forces over the past three decades, the structure, content, and even the purpose of the sociology minor has been ignored. In this article, we address this gap in the literature through two investigations. The first utilizes an examination of the websites and academic handbooks of 248 bachelor’s degree-granting institutions to discern the structure and contents of the sociology minor. We identify four models for the sociology minor found in U.S. higher education. The second study utilizes data gathered through the ASA 2019–2020 Department Survey. Included in the survey were a variety of questions regarding department chairs’ perceptions of the sociology minor. We conclude by suggesting that we should not only be concerned with what the sociology minor currently is but also consider what the minor could be
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
Get PDFPancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that has remained clinically challenging to manage. Here we employ an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across a panel of patient-derived PDAC models. Through this, we identify protein arginine methyltransferase 1 (PRMT1) as a critical dependency required for PDAC maintenance. Genetic and pharmacological studies validate the role of PRMT1 in maintaining PDAC growth. Mechanistically, using proteomic and transcriptomic analyses, we demonstrate that global inhibition of asymmetric arginine methylation impairs RNA metabolism, which includes RNA splicing, alternative polyadenylation, and transcription termination. This triggers a robust downregulation of multiple pathways involved in the DNA damage response, thereby promoting genomic instability and inhibiting tumor growth. Taken together, our data support PRMT1 as a compelling target in PDAC and informs a mechanism-based translational strategy for future therapeutic development.
Statement of significance
PDAC is a highly lethal cancer with limited therapeutic options. This study identified and characterized PRMT1-dependent regulation of RNA metabolism and coordination of key cellular processes required for PDAC tumor growth, defining a mechanism-based translational hypothesis for PRMT1 inhibitors
