18054 research outputs found
Sort by
Hip Hop, Police Brutality, and Modern Incarceration
No full textThe rise of mass incarceration in Africa and the Americas has put millions of black and indigenous people of color in the prison system. We believe that the stories of struggle against the presence of white freedom should be told and the voices of victims should be heard. To do this, modern musicians are using hip hop as a tool to combat against injustice in the penal system and bring light to the experience of prison-for-profit.https://digitalcommons.butler.edu/freedom-movement-spring-2022/1003/thumbnail.jp
Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cance
Get PDFOxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who received neoadjuvant chemotherapy demonstrated that the top canonical pathway associated with worse outcome was higher expression of OXPHOS signature. IACS-10759, a novel inhibitor of OXPHOS, stabilized growth in multiple TNBC patient-derived xenografts (PDX). On gene expression profiling, all of the sensitive models displayed a basal-like 1 TNBC subtype. Expression of mitochondrial genes was significantly higher in sensitive PDXs. An in vivo functional genomics screen to identify synthetic lethal targets in tumors treated with IACS-10759 found several potential targets, including CDK4. We validated the antitumor efficacy of the combination of palbociclib, a CDK4/6 inhibitor, and IACS-10759 in vitro and in vivo. In addition, the combination of IACS-10759 and multikinase inhibitor cabozantinib had improved antitumor efficacy. Taken together, our data suggest that OXPHOS is a metabolic vulnerability in TNBC that may be leveraged with novel therapeutics in combination regimens. SIGNIFICANCE: These findings suggest that triple-negative breast cancer is highly reliant on OXPHOS and that inhibiting OXPHOS may be a novel approach to enhance efficacy of several targeted therapies
A Disease of Isolation: Alcohol Use Disorder and the COVID-19 Pandemic
Get PDFAlcohol Use Disorder (AUD) is a chronic brain disorder that results in adverse social, mental, and physical effects. Many people with AUD rely on 12-step abstinence programs to provide them the structure and support they rely on to stay sober. With the onset of the COVID-19 pandemic, patients with AUD have undergone long stretches without connection to friends and loved ones or the rigidity of a school/work schedule. This article examines the negative impacts of the pandemic on Americans with AUD, what measures are currently being taken to assist them, and what more research needs to be done
Love-Hate Relationships: The Divergent US Perceptions of Japan and China
No full textA pervasive pro-Japan bias in the U.S. has blinded Americans to the dangers of Japan’s far-right leaders – and reinforced enmity with Chin
Response to “The Assassination of John Lennon as Depicted by the Madame Tussaud Wax Museum, Niagara Falls, Ontario, 1987”
Get PDFConservation and its Effect on Indigenous Communities
Get PDFThis project investigates the effects of conservation on indigenous populations
