National Journal glaucoma / Национальный журнал глаукома
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    Методы тонометрии и роль различных проб в ранней диагностике глаукомы (часть 2)

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    This literature review depicts various tonometry methods (Maklakov, elastotonometry, Goldmann tonometry, tonometry by means of Ocular Response Analyzer (ORA) and ICare). The efficacy and accuracy characteristics of different intraocular pressure measuring methods are presented. The article sums up current research on the interdependence of the intraocular pressure and central cornea thickness, the influence of visco-elastic characteristics of the fibrous membrane of the eye on results of some tonometry methods, the correlation of biomechanical indices and interrelation of corneal hysteresis, corneal resistance factor and intraocular pressure. The review describes various tests used in early diagnostics of glaucoma: stress tests (mydriatic test, Wurgaft compression tonometry test, Heims position test, Krasnov orthoclinostatic test, corticosteroid provocative testing by B. Becker, W. Mills etc.)

    О повышении информативности теста тонометрии

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    The effect of the tonometer contact surface shape on the accuracy of measuring the true and tonometric pressures is analyzed. Possible modifications of the tonometry method, which can not only make the intraocular pressure measurement more accurate but also enable us to estimate parameters characterizing the elastic properties of the corneal and scleral eye segments, Ec and Es, are discussed. The tonometers with flat (Maklakov's method) and convex (convex-tonometry) contact surfaces are taken as examples. It is shown that the pressure measurement accuracy can be increased substantially with increase in the accuracy of the tonometer contact area radius measurement and if the individual Ec and Es values are attained from independent measurements. Possible measurement modification methods which make it possible to estimate together the individual values of the intraocular pressure and the parameters Ec and Es that separately characterize the elastic properties of the cornea and the scleral segment. The tonometry modification consists in measuring within each examination the intraocular pressure by the standard method using successively both tonometers considered, of two different weights each (four measurements). The complication of the measurement procedure is justified not only by the possibility to increase the intraocular pressure measurement accuracy but also by the possibility to simultaneously estimate the individual elastic characteristics of the cornea and the scleral segment, which may be important for diagnostics and therapeutic efficacy control

    Содержание иммуноглобулинов A, M, G в слезной жидкости у больных первичной открытоугольной глаукомой

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    PURPOSE: To define changes of immunoglobulins A, M, G in the tear fluid of patients with primary open-angle glaucoma (POAG). METHODS: We investigated the content of serum immunoglobulins and secretory immunoglobulin A in the tear fluid of patients with POAG and people with risk of its development. RESULTS: The level of IgG, which is the main immunoglobulin of the secondary immune response, was slightly elevated. Investigation of IgA concentration in the serum of patients with POAG showed an increase. Serum IgA concentration in the risk group almost did not differ from the control group. CONCLUSION: The study of immunoglobulin G, M and A in the serum of patients with POAG showed a slight increase Conflicts of Interest and Source of Funding: none declared. in their concentrations, indicating the activation of humoral mechanisms of immunopathogenesis in patients with POAG. Concentrations of secretory immunoglobulin A (sIgA) in the tear fluid was increased both in patients with POAG and in the risk group. It gives reason to consider the local humoral mechanisms an important link in the development of immune inflammation in primary open-angle glaucoma. Selective accumulation of sIgA in the tear fluid indicates an increase in the protective function of the mucous in response to any antigen, toxin, autoantigen, and the aim to limit the development of the pathological process

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    National Journal glaucoma / Национальный журнал глаукома
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